Zu "K08825" wurden 79 Artikel gefunden!
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DYRK1A Inhibitor Compound 11
Artikelnummer: Cay41715-1
DYRK1A inhibitor compound 11 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A, IC50 = 0.4 nM). It is selective for DYRK1A over DYRK2, CDC-like kinase 1 (Clk1), Clk2, Clk3, cyclin-dependent kinase 2 (Cdk2), and glycogen synthase kinase 3beta (GSK3beta, IC50s = 19, 7.1, 9.4, 54,...
| Schlagworte: | Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A Inhibitor Compound 11, DYRK1 Inhibitor 1, DYRK1-IN-1,... |
| Anwendung: | DYRK1A inhibitor |
| CAS | 2814486-79-6 |
| MW: | 240.3 D |
ab 95,00 €
Harmine
Artikelnummer: TGM-T1711-100mg
Description: Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. Target: MAO, 5-HT Receptor, DYRK. Smiles: COc1ccc2c(c1)[nH]c1c(C)nccc21. References: Zhang H, et al. Phytomedicine. 2014 Feb 15,21(3):348-55.
| Schlagworte: | Telepathine |
| Anwendung: | Potent ATP-competitive, selective DYRK1A / DYRK2 / DYRK3 inhibitor |
| CAS | 442-51-3 |
| MW: | 212.25 D |
ab 31,00 €
INDY
Artikelnummer: TGM-T15579-10mg
Description: INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 µM and 0.23 µM and a Ki of 0.18 µM for Dyrk1A ATP pocket, respectively. Target: DYRK. Smiles: CCN1\C(Sc2ccc(O)cc12)=C\C(C)=O. References: Ogawa Y, et al. Development of a novel selective inhibitor of the Down syndrome-related...
| Schlagworte: | 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one |
| Anwendung: | Potent selective ATP-competitive DYRK1A / DYRK1B inhibitor |
| CAS | 1169755-45-6 |
| MW: | 235.3 D |
ab 55,00 €
Leucettinib-21
Artikelnummer: AG-MR-C0047-M001
Potent inhibitor of DYRK1A (IC50=2.4nM), DYRK1B (IC50=6.7nM), CLK1 (IC50=11.8nM) and CLK4 (IC50=5nM) kinases [2]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286, native DYRK1A in HT-22 cells and triggers cell apoptotic cell death. Corrects cognitive deficits in Ts65Dn model of Down syndrome...
| Schlagworte: | LCTB-21, (R,Z)-5-(Benzo[d]thiazol-6-ylmethylene)-2-((1-methoxy-4-methylpentan-2-yl)amino)-3,5-dihydro-4H-imidazol-4-one |
| Anwendung: | DYRK1 inhibitor |
| CAS | 2732859-75-3 |
| MW: | 358,5 D |
ab 99,00 €
iso-Leucettinib-21
Artikelnummer: AG-MR-C0048-M001
Kinase inactive isomer of Leucettinib-21 (IC50 DYRK1A > 10 µM). Should be used as a negative control for Leucettinb-21 (Prod. No. AG-MR-C0047). Does not inhibit the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286, native DYRK1A in HT-22 cells and does not trigger cell apoptotic cell death. Does not correct...
| Schlagworte: | iso-LCTB-21, (R,Z)-6-(Benzo[d]thiazol-5-ylmethylene)-2-((1-methoxy-4-methylpentan-2-yl)amino)-3,5-dihydro-4H-imidazol-4-one |
| Anwendung: | Leucettinb-21 negative control |
| CAS | 3032977-73-1 |
| MW: | 358,5 D |
ab 99,00 €
Harmine hydrochloride
Artikelnummer: TGM-T2811-100mg
Description: Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. Target: 5-HT Receptor, DYRK, GluR. Smiles: Cl.COc1ccc2c(c1)[nH]c1c(C)nccc21. References: Sun P, et al. Neurosci Lett. 2014 Nov 7,583:32-6.
| Schlagworte: | telepathine hydrochloride |
| Anwendung: | MAO-A and DYRK inhibitor |
| CAS | 343-27-1 |
| MW: | 248.71 D |
ab 42,00 €
AnnH31
Artikelnummer: TGM-T26632-1mg
Description: AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 µM.AnnH31 can be used as a probe to confirm the involvement of DYRK1A in cellular phosphorylation. Target: DYRK, MAO. Smiles: C(C#N)N1C=2C(C=3C1=C(C)N=CC3)=CC=C(OC)C2. References: Rüben K, et al....
| Anwendung: | Potent selective membrane-permeable DYRK1A / DYRK1B inhibitor |
| CAS | 241809-12-1 |
| MW: | 251.28 D |
ab 212,00 €
AZ191
Artikelnummer: TGM-T6257-10mg
Description: AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively. Target: DYRK. Smiles: COc1cc(ccc1Nc1nccc(n1)-c1cn(C)c2cnccc12)N1CCN(C)CC1. References: Ashford AL, et al. Biochem J. 2014, 457(1),...
| Anwendung: | Cell permeable DYRK1B inhibitor |
| CAS | 1594092-37-1 |
| MW: | 429.52 D |
ab 40,00 €
Anti-DYRK1B
Artikelnummer: CSB-PA908230.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-MIRK, Anti-DYRK1B, Anti-Mirk protein kinase, Anti-Minibrain-related kinase, Anti-Dual specificity... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
283,00 €
Anti-DYRK1A
Artikelnummer: CSB-PA002232.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-hMNB, Anti-DYRK, Anti-MNBH, Anti-HP86, Anti-DYRK1A, Anti-Protein kinase minibrain homolog, Anti-Dual specificity... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
126,00 €
Leucettine L41
Artikelnummer: AG-MR-C0023-M005
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3 alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against...
| Schlagworte: | (5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one |
| Anwendung: | DYRK / CLK inhibitor |
| CAS | 1112978-84-3 |
| MW: | 307,3 D |
ab 72,00 €
AZ191
Artikelnummer: AG-CR1-3657-M001
White to off-white solid. Soluble in DMSO (5mg/ml), ethanol (2mg/ml) or DMF (2mg/ml). Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively, Used as a probe to elucidate...
| Schlagworte: | N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine |
| Anwendung: | Cell permeable DYRK1B inhibitor |
| CAS | 1594092-37-1 |
| MW: | 429,5 D |
ab 28,00 €