Zu "K08825" wurden 81 Artikel gefunden!
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Mouse DYRK1A (Dual Specificity Tyrosine Phosphorylation...
Artikelnummer: ELK-ELK6307.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse DYRK1A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse DYRK1A....
| Schlagworte: | MP86, MNBH, Dyrk, Dyrk1a, Protein kinase minibrain homolog, Dual specificity YAK1-related kinase, Dual specificity... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Human DYRK1A (Dual Specificity Tyrosine Phosphorylation...
Artikelnummer: ELK-ELK4408.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DYRK1A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DYRK1A....
| Schlagworte: | hMNB, DYRK, MNBH, HP86, Protein kinase minibrain homolog, Dual specificity YAK1-related kinase, Dual specificity... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Leucettine L41
Artikelnummer: AG-MR-C0023-M001
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3 alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against...
| Schlagworte: | (5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one |
| Anwendung: | DYRK / CLK inhibitor |
| CAS | 1112978-84-3 |
| MW: | 307,3 D |
ab 72,00 €
AZ191
Artikelnummer: AG-CR1-3657-M001
White to off-white solid. Soluble in DMSO (5mg/ml), ethanol (2mg/ml) or DMF (2mg/ml). Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively, Used as a probe to elucidate...
| Schlagworte: | N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine |
| Anwendung: | Cell permeable DYRK1B inhibitor |
| CAS | 1594092-37-1 |
| MW: | 429,5 D |
ab 28,00 €
TG007
Artikelnummer: AG-CR1-3666-M005
White to off-white solid. Soluble in DMSO (10mg/ml). Prodrug form (acetylated derivative) of INDY (Prod. No. AG-CR1-3665), Cell permeable ATP-competitive DYRK1A and DYRK1B inhibitor, Inhibits phosphorylation of Tau-protein and rescues repressed calcineurin/NFAT signaling, Recovers Xenopus embryos from head...
| Schlagworte: | (Z)-3-Ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate, ProINDY |
| Anwendung: | Cell permeable ATP-competitive DYRK1A / DYRK1B inhibitor prodrug |
| CAS | 719277-30-2 |
| MW: | 277,3 D |
88,00 €
AZ191
Artikelnummer: Cay17693-1
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene...
| Schlagworte: | N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine |
| Anwendung: | Cell-permeable DYRK1B serine/threonine kinase activity inhibitor |
| CAS | 1594092-37-1 |
| MW: | 429.5 D |
ab 43,00 €
DYRK1A/B Inhibitor AnnH75
Artikelnummer: AG-CR1-3651-C500
Pale yellow solid. Soluble in DMSO. Potent selective membrane-permeable DYRK1A (IC50=181nM) and DYRK1B inhibitor. Off-target inhibition of CLK1, CLK4 and Haspin/GSG2, Shows no inhibitory effects on monoamine oxidase A (MAO A), Inhibited the cotranslational tyrosine autophosphorylation of DYRK1A and threonine...
| Schlagworte: | 2-(1-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-9-yl)acetonitrile, AnnH75 |
| Anwendung: | Potent selective membrane-permeable DYRK1A / DYRK1B inhibitor |
| MW: | 271,7 D |
154,00 €
Anti-MIRK
Artikelnummer: A302-483A-T
Protein function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways,...
| Schlagworte: | Anti-MIRK, Anti-DYRK1B, EC=2.7.12.1, Anti-Mirk protein kinase, Anti-Minibrain-related kinase, Anti-Dual specificity... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Harmine
Artikelnummer: AG-CN2-0510-M010
White ot off-white solid. Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. Fluorescent beta-carboline alkaloid, Potent ATP-competitive and selective inhibitor of DYRK1A, DYRK2 and DYRK3 with IC50 values of 0.08, 0.9 and 0.8µM. Shown to inhibit CLK2, PIM3 (at 4.3µM) and CK1 at 1.5µM as well. Inhibits...
| Schlagworte: | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole, Banisterine, Leucoharmine, Telepathine, Yageine, BRN0178813 |
| Anwendung: | Potent ATP-competitive, selective DYRK1A / DYRK2 / DYRK3 inhibitor |
| CAS | 442-51-3 |
| MW: | 212,3 D |
ab 28,00 €
INDY
Artikelnummer: AG-CR1-3665-M005
White to off-white solid. Soluble in DMSO (10mg/ml). Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme, Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same...
| Schlagworte: | (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Anwendung: | Potent selective ATP-competitive DYRK1A / DYRK1B inhibitor |
| CAS | 1169755-45-6 |
| MW: | 235,3 D |
88,00 €
DYRK1A/B Inhibitor AnnH31
Artikelnummer: AG-CR1-3650-C500
Off-white to tan solid. Soluble in DMSO. Potent selective membrane-permeable DYRK1A (IC50=81nM) and DYRK1B inhibitor. Off-target inhibition of CLK1 and slightly DYRK2 and HIPK2, Shows minimal inhibitory effects on monoamine oxidase A (MAO A) (IC50=3.2µg), with 40-fold selectivity for DYRK1A over MAO A,...
| Schlagworte: | 2-(7-Methoxy-1-methyl-9H-pyrido[3,4-b]indol-9-yl)acetonitrile, AnnH31 |
| Anwendung: | Potent selective membrane-permeable DYRK1A / DYRK1B inhibitor |
| CAS | 241809-12-1 |
| MW: | 251,3 D |
154,00 €
DYRK1 Inhibitor Negative Control AnnH79
Artikelnummer: AG-CR1-3652-C500
Off-white to pale yellow solid. Soluble in DMSO. Inactive harmine analog that does not inhibit DYRK1A/DYRK1B, Useful as negative control for beta-carboline analog DYRK1A/B inhibitors.
| Schlagworte: | 2-(1-Bromo-7,8-dichloro-9H-pyrido[3,4-b]indol-9-yl)acetonitrile, AnnH79 |
| Anwendung: | Negative control |
| MW: | 355,0 D |
154,00 €