Zu "K08823" wurden 63 Artikel gefunden!
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SGC-CLK-1
Artikelnummer: Cay41311-1
SGC-CLK-1 is an inhibitor of CDC-like kinase 1 (Clk1) and Clk2 (IC50s = 13 and 4 nM, respectively). It is selective for Clk1 and Clk2 over Clk3, Clk4, homeodomain-interacting protein kinase 1 (HIPK1), HIPK2, and serine/threonine kinase 16 (STK16, IC50s = 363, 46, 50, 42, and 49 nM, respectively). SGC-CLK-1 (1 µM)...
| Schlagworte: | CAF-170, CDC-like Kinase 1,... |
| Anwendung: | Clk1 / Clk2 inhibitor |
| CAS | 748142-15-6 |
| MW: | 416.4 D |
ab 40,00 €
Adavivint
Artikelnummer: TGM-T5636-100mg
Description: Adavivint (SM04690) is a selective inhibitor of the typical Wnt signaling pathway. In SW480 cells, EC50=19.5 nM was measured using high-throughput TCF/LEF reporter gene experiments. Target: Wnt/beta-catenin. Smiles: CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1. References:...
| Schlagworte: | Adavivint (SM04690) |
| Anwendung: | Targets dual specificity protein kinase CLK2/3 [EC:2.7.12.1] (CLK2_3) |
| CAS | 1467093-03-3 |
| MW: | 505.55 D |
ab 42,00 €
CLK3 Protein, Human, Recombinant (GST)
Artikelnummer: TGM-TMPY-04546-50ug
Description: Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity kinases (termed Lammer kinases) that have been conserved in evolution. CLK family...
| Schlagworte: | PHCLK3/152, CDC-like kinase 3, PHCLK3 |
| MW: | 85 kD |
397,00 €
(E/Z)-TG003
Artikelnummer: TGM-T1901-100mg
Description: (E/Z)-TG003 is a potent and ATP-competitive inhibitor of Cdc2-like kinase (Clk). Target: BCL, CDK. Smiles: CCN1\C(Sc2ccc(OC)cc12)=C/C(C)=O. References: Muraki M, et al. J Biol Chem. 2004, 279(23), 24246-24254.
| Schlagworte: | TG003 |
| Anwendung: | Potent specific reversible and ATP-competitive cell permeable Clk inhibitor |
| CAS | 300801-52-9 |
| MW: | 249.33 D |
ab 37,00 €
Leucettinib-92
Artikelnummer: AG-MR-C0049-M001
Potent inhibitor of DYRK1A (IC50=1.2nM), DYRK1B (IC50=1.8nM), DYRK3 (IC50=19.3nM) and CLK2 (IC50=0.6nM) [1]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286. Corrects cognitive deficits in animal models of Down syndrome. iso-Leucettinib-92 (Prod. No. AG-MR-C0050) is a kinase-inactive isomer and...
| Schlagworte: | LCTB-92, (Z)-2-((Adamantan-1-yl)amino)-5-(benzo[d]thiazol-6-ylmethylene)-3,5-dihydro-4H-imidazol-4-one |
| Anwendung: | CLK2/DYRK1 inhibitor |
| CAS | 2732859-57-1 |
| MW: | 378,5 D |
ab 132,00 €
iso-Leucettinib-92
Artikelnummer: AG-MR-C0050-M001
Kinase inactive isomer of Leucettinib-92 (IC50 DYRK1A > 3 µM) [2]. Should be used as a negative control for Leucettinb-92 (Prod. No. AG-MR-C0049). Does not inhibit the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286. Does not correct cognitive deficits in animal models of Down syndrome.
| Schlagworte: | iso-LCTB-92, (Z)-2-((Adamantan-1-yl)amino)-5-(benzo[d] thiazol-5-ylmethylene)-3,5-dihydro-4H-imidazol-4-one |
| Anwendung: | Leucettinb-92 negative control |
| CAS | 2649456-57-3 |
| MW: | 378,5 D |
ab 132,00 €
CC-671
Artikelnummer: TGM-T4482-100mg
Description: CC-671 is a dual inhibitor of TTK protein kinase (IC50: 0.005 µM) and CLK2 (IC50: 0.006 µM). Target: CDK, Others. Smiles: CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1. References: Riggs JR, et al. The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for...
| Anwendung: | TTK / CLK2 inhibitor |
| CAS | 1618658-88-0 |
| MW: | 512.56 D |
ab 48,00 €
Anti-CLK2
Artikelnummer: CSB-PA001718.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-CLK2, EC=2.7.12.1, Anti-CDC-like kinase 2, Anti-Dual specificity protein kinase CLK2, CDC like kinase 2 antibody,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-CLK2
Artikelnummer: CSB-PA562044.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-CLK2, EC=2.7.12.1, Anti-CDC-like kinase 2, Anti-Dual specificity protein kinase CLK2, CDC like kinase 2 antibody,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
283,00 €
Dual specificity protein kinase CLK2 (CLK2), partial,...
Artikelnummer: CSB-EP005558HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 138-499aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: RRAKSVEDDA EGHLIYHVGD WLQERYEIVS TLGEGTFGRV VQCVDHRRGG ARVALKIIKN VEKYKEAARL EINVLEKINE KDPDNKNLCV QMFDWFDYHG HMCISFELLG LSTFDFLKDN NYLPYPIHQV...
| Schlagworte: | CLK2, EC=2.7.12.1, CDC-like kinase 2, Dual specificity protein kinase CLK2, Recombinant Human Dual specificity protein... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 58.7 kD |
ab 292,00 €
Dual specificity protein kinase CLK2 (CLK2), partial,...
Artikelnummer: CSB-EP005558HU1a6.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 138-499aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-B2M-tagged. Target Protein Sequence: RRAKSVEDDA EGHLIYHVGD WLQERYEIVS TLGEGTFGRV VQCVDHRRGG ARVALKIIKN VEKYKEAARL EINVLEKINE KDPDNKNLCV QMFDWFDYHG HMCISFELLG LSTFDFLKDN NYLPYPIHQV...
| Schlagworte: | CLK2, EC=2.7.12.1, CDC-like kinase 2, Dual specificity protein kinase CLK2, Recombinant Human Dual specificity protein... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 56.7 kD |
ab 292,00 €
ML-167
Artikelnummer: Cay18098-10
The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas DYRKs interact with and activate splicing factors. ML167 is a...
| Schlagworte: | CID 44968231, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol |
| Anwendung: | Clk4 inhibitor |
| CAS | 1285702-20-6 |
| MW: | 335.4 D |
ab 36,00 €