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Zu "K08822" wurden 84 Artikel gefunden!
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Artikelnummer: ELK-ELK1707.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GSK3a. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GSK3a. Next,...
Schlagworte: | GSK3A, GSK-3 alpha, EC=2.7.11.26, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK1708.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GSK3a. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GSK3a. Next,...
Schlagworte: | FA, Gsk3a, Factor A, EC=2.7.11.1, GSK-3 alpha, EC=2.7.11.26, Glycogen synthase kinase-3 alpha, Serine/threonine-protein... |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: Cay37314-1
BRD0705 is an inhibitor of glycogen synthase kinase 3alpha (GSK3alpha, IC50 = 66 nM). It is selective for GSK3alpha over GSK3beta (IC50 = 515 nM). BRD0705 (10 and 20 µM) inhibits GSK3alpha autophosphorylation in U937 cells. It impairs colony formation of MOLM-13, TF-1, U937, MV4-11, HL-60, and NB4 acute myeloid...
Schlagworte: | (4S)-4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-5H-pyrazolo[3,4-b]quinolin-5-one |
Anwendung: | GSK3alpha inhibitor |
CAS | 2056261-41-5 |
MW: | 321.4 D |
ab 61,00 €
Artikelnummer: Cay13123-5
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3alpha/beta (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A,...
Schlagworte: | GSK3 Inhibitor IX, 6-Bromoindirubin-3'-oxime, MLS 2052,... |
Anwendung: | GSK-3 inhibitor |
CAS | 667463-62-9 |
MW: | 356.2 D |
ab 43,00 €
Artikelnummer: Cay10010246-10
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3alpha with an IC50...
Schlagworte: | 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
Anwendung: | GSK inhibitor |
CAS | 280744-09-4 |
MW: | 371.2 D |
ab 98,00 €
Artikelnummer: Cay22211-1
LY2090314 is potent and selective inhibitor of glycogen synthase kinase 3 (GSK3) with IC50 values of 1.5 and 0.9 nM for human recombinant GSK3alpha and GSK3beta, respectively. It has >10-fold selectivity for GSK3 over a panel of 40 kinases at a concentration of 20 µM. LY2090314 induces time-dependent stabilization...
Schlagworte: | 3-[9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-... |
Anwendung: | GSK-3alpha / GSK-3beta inhibitor |
CAS | 603288-22-8 |
MW: | 512.5 D |
ab 43,00 €
Artikelnummer: AG-CR1-3659-M005
Solid. Soluble in DMSO (20mg/ml) or ethanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 34nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.8µM), Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription,...
Schlagworte: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
Anwendung: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
CAS | 280744-09-4 |
MW: | 371,2 D |
ab 39,00 €
Artikelnummer: BPS-40006
Active human GSK3alpha GenBank Accession No. BC027984), full length, with N-terminal GST tag, MW=81.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: | GSK3A, GSK-3 alpha, EC=2.7.11.26, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A, |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 81.5 kD |
540,00 €
Artikelnummer: Cay16676-1
The two isoforms of glycogen synthase kinase 3, GSK3alpha and GSK3beta, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer's disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of...
Schlagworte: | 2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile |
Anwendung: | Brain permeable GSK3alpha/beta inhibitor |
CAS | 612487-72-6 |
MW: | 334.4 D |
ab 37,00 €
Artikelnummer: Cay14155-10
Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 µM) and cyclin-dependent kinases 1 and 5 (IC50 =...
Schlagworte: | C.I. 73200, Couroupitine B, Indigopurpurin, NSC 105327, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one |
Anwendung: | GSK-3 inhibitor, CDK1/5 inhibitor |
CAS | 479-41-4 |
MW: | 262.3 D |
ab 82,00 €
Artikelnummer: Cay15578-1
The two isoforms of glycogen synthase kinase 3, GSK3alpha and GSK3beta, constitutively phosphorylates and inactivates glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer's disease and osteogenesis. CHIR98014 is a reversible, cell-permeable inhibitor of...
Schlagworte: | N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine |
Anwendung: | GSK3alpha / GSK3beta inhibitor |
CAS | 252935-94-7 |
MW: | 486.3 D |
ab 109,00 €
Artikelnummer: AG-CR1-3658-M001
Yellow solid. Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or methanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.9µM), Stimulates glycogen synthesis in liver cells and induces...
Schlagworte: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
Anwendung: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
CAS | 264218-23-7 |
MW: | 359,7 D |
ab 33,00 €