Zu "K08822" wurden 108 Artikel gefunden!
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Anti-Recombinant Phospho-GSK3 alpha, beta (Tyr216,...
Artikelnummer: E-AN300656L.100
GSK3A(glycogen synthase kinase 3 alpha) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated inThe control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role inThe WNT and PI3K signaling pathways, as well as...
| Schlagworte: | Anti-GSK3A, Anti-Glycogen synthase kinase-3 alpha, Anti-Serine/threonine-protein kinase GSK3A, Recombinant Phospho-GSK3... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant GSK3alpha, clone 4F4
Artikelnummer: E-AN300947L.100
GSK3A(glycogen synthase kinase 3 alpha) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as...
| Schlagworte: | Anti-GSK3A, Anti-Glycogen synthase kinase-3 alpha, Anti-Serine/threonine-protein kinase GSK3A, Recombinant GSK3alpha... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
BIO
Artikelnummer: Cay13123-5
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3alpha/beta (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A,...
| Schlagworte: | GSK3 Inhibitor IX, 6-Bromoindirubin-3'-oxime, MLS 2052,... |
| Anwendung: | GSK-3 inhibitor |
| CAS | 667463-62-9 |
| MW: | 356.2 D |
ab 49,00 €
SB-216763
Artikelnummer: Cay10010246-10
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3alpha with an IC50...
| Schlagworte: | 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Anwendung: | GSK inhibitor |
| CAS | 280744-09-4 |
| MW: | 371.2 D |
ab 73,00 €
LY2090314
Artikelnummer: Cay22211-1
LY2090314 is potent and selective inhibitor of glycogen synthase kinase 3 (GSK3) with IC50 values of 1.5 and 0.9 nM for human recombinant GSK3alpha and GSK3beta, respectively. It has >10-fold selectivity for GSK3 over a panel of 40 kinases at a concentration of 20 µM. LY2090314 induces time-dependent stabilization...
| Schlagworte: | 3-[9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-... |
| Anwendung: | GSK-3alpha / GSK-3beta inhibitor |
| CAS | 603288-22-8 |
| MW: | 512.5 D |
ab 49,00 €
SB216763
Artikelnummer: AG-CR1-3659-M005
Solid. Soluble in DMSO (20mg/ml) or ethanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 34nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.8µM), Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription,...
| Schlagworte: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Anwendung: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 280744-09-4 |
| MW: | 371,2 D |
ab 33,00 €
6BIO
Artikelnummer: AG-MR-C0019-M010
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative...
| Schlagworte: | BIO, 6-Bromoindirubin-3'-oxime |
| Anwendung: | GSK-3alpha/beta inhibitor |
| CAS | 667463-62-9 |
| MW: | 356,2 D |
ab 154,00 €
GSK3alpha, active human recombinant protein
Artikelnummer: BPS-40006
Active human GSK3alpha GenBank Accession No. BC027984), full length, with N-terminal GST tag, MW=81.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | GSK3A, GSK-3 alpha, EC=2.7.11.26, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 81.5 kD |
551,00 €
AZD 1080
Artikelnummer: Cay16676-1
The two isoforms of glycogen synthase kinase 3, GSK3alpha and GSK3beta, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer's disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of...
| Schlagworte: | 2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile |
| Anwendung: | Brain permeable GSK3alpha/beta inhibitor |
| CAS | 612487-72-6 |
| MW: | 334.4 D |
ab 44,00 €
Indirubin
Artikelnummer: Cay14155-10
Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 µM) and cyclin-dependent kinases 1 and 5 (IC50 =...
| Schlagworte: | C.I. 73200, Couroupitine B, Indigopurpurin, NSC 105327, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one |
| Anwendung: | GSK-3 inhibitor, CDK1/5 inhibitor |
| CAS | 479-41-4 |
| MW: | 262.3 D |
ab 92,00 €
CHIR98014
Artikelnummer: Cay15578-1
The two isoforms of glycogen synthase kinase 3, GSK3alpha and GSK3beta, constitutively phosphorylates and inactivates glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer's disease and osteogenesis. CHIR98014 is a reversible, cell-permeable inhibitor of...
| Schlagworte: | N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine |
| Anwendung: | GSK3alpha / GSK3beta inhibitor |
| CAS | 252935-94-7 |
| MW: | 486.3 D |
ab 122,00 €
SB415286
Artikelnummer: AG-CR1-3658-M001
Yellow solid. Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or methanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.9µM), Stimulates glycogen synthesis in liver cells and induces...
| Schlagworte: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Anwendung: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 264218-23-7 |
| MW: | 359,7 D |
ab 33,00 €