Zu "K08819" wurden 56 Artikel gefunden!
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SR-4835
Artikelnummer: TGM-T8325-100mg
Description: SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM, CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells. Target: Apoptosis, CDK. Smiles: Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1. References: Quereda V, et al....
| Anwendung: | Cdk12 / Cdk13 inhibitor |
| CAS | 2387704-62-1 |
| MW: | 499.36 D |
ab 52,00 €
BSJ-4-116
Artikelnummer: TGM-T9117-100mg
Description: BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). Target: CDK, PROTACs. Smiles:...
| Anwendung: | PROTAC, Cdk12 degradation |
| CAS | 2519823-34-6 |
| MW: | 837.38 D |
ab 49,00 €
NXF2 Protein, Drosophila melanogaster, Recombinant (His)
Artikelnummer: TGM-TMPH-00506-100ug
Description: NXF2 Protein, Drosophila melanogaster, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 33.7 kDa and the accession number is Q9VV73.
| Schlagworte: | Nuclear RNA export factor 2, nxf2 |
| MW: | 33.7 kD |
ab 491,00 €
THZ531
Artikelnummer: TGM-T4293-100mg
Description: THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). Target: CDK. Smiles: CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12. References: Zhang T, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem...
| Anwendung: | CDK12 inhibitor, CDK13 inhibitor |
| CAS | 1702809-17-3 |
| MW: | 558.07 D |
ab 57,00 €
Anti-CDK12
Artikelnummer: CSB-PA998940.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CDK12. Antigen Species: Human
| Schlagworte: | Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 12,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Nuclear RNA export factor 2 (nxf2), partial, Drosophila...
Artikelnummer: CSB-BP016219DLU.1
Organism: Drosophila melanogaster (Fruit fly). Source: Baculovirus. Expression Region: 573-841aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: QKNFLCDTGA YELVGAFLEN YLREFENDEF RHNLYKYYSE NSIFTLTCNY NVVQNHQTPK ILQRLSKYNR HARNLRNKDY SKASDGVFFG CTYIVEILLQ LPRVTHDFHS LQTDVMHYNG...
| Schlagworte: | nxf2, CG4118, Nuclear RNA export factor 2, Recombinant Drosophila melanogaster Nuclear RNA export factor 2 (nxf2), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | Drosophila melanogaster |
| MW: | 33.7 kD |
ab 489,00 €
Nuclear RNA export factor 2 (nxf2), partial, Drosophila...
Artikelnummer: CSB-EP016219DLU.1
Organism: Drosophila melanogaster (Fruit fly). Source: E.coli. Expression Region: 573-841aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: QKNFLCDTGA YELVGAFLEN YLREFENDEF RHNLYKYYSE NSIFTLTCNY NVVQNHQTPK ILQRLSKYNR HARNLRNKDY SKASDGVFFG CTYIVEILLQ...
| Schlagworte: | nxf2, CG4118, Nuclear RNA export factor 2, Recombinant Drosophila melanogaster Nuclear RNA export factor 2 (nxf2), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | Drosophila melanogaster |
| MW: | 38.4 kD |
ab 292,00 €
Anti-CDC2L5
Artikelnummer: A301-458A
Protein function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation....
| Schlagworte: | Anti-CDC2L, Anti-CDK13, Anti-hCDK13, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 13, Anti-CDC2-related... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-CrkRS
Artikelnummer: A301-679A-T
Protein function: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic...
| Schlagworte: | Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 12,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
THZ531
Artikelnummer: Cay26386-1
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively). It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 µM, respectively). THZ531 inhibits proliferation...
| Schlagworte: | (2E)-N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-2-bu... |
| Anwendung: | CDK12 inhibitor, CDK13 inhibitor |
| CAS | 1702809-17-3 |
| MW: | 558.1 D |
ab 61,00 €
Human CDK12 / CrkRS ELISA Kit
Artikelnummer: G-HUFI02005.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Roscovitine
Artikelnummer: LKT-R5774.10
Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels, it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma cells, roscovitine induces cell cycle arrest and apoptosis and inhibits proliferation.
| Schlagworte: | Seliciclib, CYC202 |
| Anwendung: | CDK inhibitor |
| CAS | 186692-46-6 |
| MW: | 354.45 D |
ab 164,00 €