Zu "K08819" wurden 63 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Cdk12-IN-2
Artikelnummer: Cay43703-1
Cdk12-IN-2 is an inhibitor of Cdk12 and Cdk13 (IC50s = 0.052 and 0.01 µM, respectively). It is selective for Cdk12 over Cdk2, -7, -8, and -9 (IC50s = >100, >10, >10, and 16 µM, respectively). Cdk12-IN-2 inhibits RNA polymerase II phosphorylation in SK-BR-3 cells (IC50 = 0.195 µM). SMILES...
| Schlagworte: | Cdk12 Inhibitor 2, Cyclin-dependent Kinase 12 Inhibitor 2, Cyclin-dependent Kinase 12-IN-2,... |
| Anwendung: | Cdk12 / Cdk13 inhibitor |
| CAS | 2244987-03-7 |
| MW: | 532.65 D |
ab 91,00 €
Anti-CrkRS
Artikelnummer: A301-679A-T
Protein function: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic...
| Schlagworte: | Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 12,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-CDC2L5
Artikelnummer: A301-458A
Protein function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation....
| Schlagworte: | Anti-CDC2L, Anti-CDK13, Anti-hCDK13, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 13, Anti-CDC2-related... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
THZ531
Artikelnummer: Cay26386-1
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively). It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 µM, respectively). THZ531 inhibits proliferation...
| Schlagworte: | (2E)-N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-2-bu... |
| Anwendung: | CDK12 inhibitor, CDK13 inhibitor |
| CAS | 1702809-17-3 |
| MW: | 558.1 D |
ab 69,00 €
SR 4835
Artikelnummer: Cay39158-25
SR 4835 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13. It binds to Cdk12 and Cdk13 (Kds = 98 and 4.9 nM, respectively) and inhibits Cdk12- and Cdk13-dependent phosphorylation of RNA polymerase II in MDA-MB-231 cells (EC50 = 105.5 nM). SR 4835 inhibits the proliferation of MDA-MB-231, MDA-MB-468, Hs...
| Schlagworte: | N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine |
| Anwendung: | Cdk12 / Cdk13 inhibitor |
| CAS | 2387704-62-1 |
| MW: | 499.4 D |
ab 57,00 €
THZ531
Artikelnummer: TGM-T4293-1mg
Description: THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). Target: CDK. Smiles: CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12. References: Zhang T, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem...
| Anwendung: | CDK12 inhibitor, CDK13 inhibitor |
| CAS | 1702809-17-3 |
| MW: | 558.07 D |
ab 54,00 €
SR-4835
Artikelnummer: TGM-T8325-10mg
Description: SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM, CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells. Target: Apoptosis, CDK. Smiles: Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1. References: Quereda V, et al....
| Anwendung: | Cdk12 / Cdk13 inhibitor |
| CAS | 2387704-62-1 |
| MW: | 499.36 D |
ab 48,00 €
Human CDK12 / CrkRS ELISA Kit
Artikelnummer: G-HUFI02005.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Roscovitine
Artikelnummer: LKT-R5774.10
Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels, it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma cells, roscovitine induces cell cycle arrest and apoptosis and inhibits proliferation.
| Schlagworte: | Seliciclib, CYC202 |
| Anwendung: | CDK inhibitor |
| CAS | 186692-46-6 |
| MW: | 354.45 D |
ab 163,00 €
CDK13/Cyclin K, GST-Tags
Artikelnummer: BPS-101128-1
Complex of human CDK13 (cyclin dependent kinase 13) and human cyclin K. The proteins were co-expressed in Sf9 insect cells along with S. cerevisiae CAK1 (Serine/threonine-protein kinase CAK1). Recombinant human CDK13, encompassing amino acids 516-1512 (end), contains an N-terminal GST-tag. Recombinant human Cyclin...
| Schlagworte: | CDK13, CDC2L, hCDK13, EC=2.7.11.22, EC=2.7.11.23, Cyclin-dependent kinase 13, CDC2-related protein kinase 5, Cell division... |
| Anwendung: | Kinase research |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 138+90 kD |
ab 378,00 €
Anti-CDK12
Artikelnummer: ATA-HPA008038.100
Protein function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic...
| Schlagworte: | Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.23, EC=2.7.11.22, Anti-Cyclin-dependent kinase 12,... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-CDK13
Artikelnummer: ATA-HPA059241.100
Protein function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation....
| Schlagworte: | Anti-CDC2L, Anti-CDK13, Anti-hCDK13, EC=2.7.11.23, EC=2.7.11.22, Anti-Cyclin-dependent kinase 13, Anti-CDC2-related... |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €