Zu "K08799" wurden 45 Artikel gefunden!
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MELK-8a (hydrochloride)
Artikelnummer: Cay37025-10
MELK-8a is an inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 0.002 µM). It is selective for MELK over FLT3, haspin, KIT, and PDGFRalpha, (IC50s = 0.18, 0.19, >10, and 0.42 µM, respectively), as well as a panel of 456 kinases at 1 µM. MELK-8a inhibits the proliferation of MDA-MB-468 and MCF-7...
| Schlagworte: | NVS-MELK8a, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-piperazine, monohydrochloride |
| Anwendung: | MELK inhibitor |
| CAS | 2096992-20-8 |
| MW: | 469 D |
ab 134,00 €
MELK Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01642-100ug
Description: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and...
| Schlagworte: | Protein kinase Eg3, Tyrosine-protein kinase MELK, MELK, Maternal embryonic leucine zipper kinase, Protein kinase PK38 |
| MW: | 44.3 kD |
ab 281,00 €
MELK-8a hydrochloride
Artikelnummer: TGM-T11996-100mg
Description: MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). Target: MELK. Smiles: Cl.CN1CCN(CC1)c1ccc(cc1)-n1cc(cn1)-c1ccncc1OCC1CCNCC1. References: Touré BB, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery,...
| Anwendung: | MELK inhibitor |
| CAS | 2096992-20-8 |
| MW: | 469.02 D |
ab 37,00 €
OTSSP167 hydrochloride
Artikelnummer: TGM-T21559-1mg
Description: OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM). Target: MELK. Smiles: Cl.CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O. References: Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses...
| Anwendung: | MELK inhibitor |
| CAS | 1431698-10-0 |
| MW: | 523.88 D |
ab 34,00 €
Anti-MELK
Artikelnummer: CSB-PA582122.100
Host Species: Rabbit. Isotype: IgG. Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits...
| Schlagworte: | Anti-MELK, Anti-hPK38, Anti-hMELK, Anti-KIAA0175, EC=2.7.10.2, Anti-pEg3 kinase, EC=2.7.11.1, Anti-Protein kinase Eg3,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
283,00 €
Maternal embryonic leucine zipper kinase (MELK), partial,...
Artikelnummer: CSB-EP013692HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-340aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MKDYDELLKY YELHETIGTG GFAKVKLACH ILTGEMVAIK IMDKNTLGSD LPRIKTEIEA LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR...
| Schlagworte: | MELK, hPK38, hMELK, KIAA0175, EC=2.7.10.2, pEg3 kinase, EC=2.7.11.1, Protein kinase Eg3, Protein kinase PK38,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 44.3 kD |
ab 292,00 €
OTSSP167 (hydrochloride)
Artikelnummer: Cay16873-1
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes. MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors. OTSSP167 is a potent...
| Schlagworte: | 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethan-1-o... |
| Anwendung: | MELK inhibitor |
| CAS | 1431698-10-0 |
| MW: | 523.9 D |
ab 85,00 €
Anti-MELK
Artikelnummer: A303-136A
Protein function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating...
| Schlagworte: | Anti-MELK, Anti-hMELK, Anti-hPK38, Anti-KIAA0175, Anti-pEg3 kinase, EC=2.7.11.1, EC=2.7.10.2, Anti-Protein kinase Eg3,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-MELK, C-terminal
Artikelnummer: ARG63141.100
Protein function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating...
| Schlagworte: | Anti-MELK, Anti-hMELK, Anti-hPK38, Anti-KIAA0175, EC=2.7.10.2, EC=2.7.11.1, Anti-pEg3 kinase, Anti-Protein kinase Eg3,... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
822,00 €
Anti-MELK
Artikelnummer: A303-137A
Protein function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating...
| Schlagworte: | Anti-MELK, Anti-hMELK, Anti-hPK38, Anti-KIAA0175, Anti-pEg3 kinase, EC=2.7.11.1, EC=2.7.10.2, Anti-Protein kinase Eg3,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
MELK, GST-tag
Artikelnummer: BPS-40708
Recombinant human MELK, Genbank Accession #NM_014791, a.a. 1- 30, with an N-terminal GST-tag, MW = 61 kDa, expressed in Sf9 cells via a baculovirus expression system.
| Schlagworte: | MELK, hPK38, hMELK, KIAA0175, pEg3 kinase, EC=2.7.11.1, EC=2.7.10.2, Protein kinase Eg3, Protein kinase PK38,... |
| Anwendung: | Studying enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 61 kD |
901,00 €
Human MELK / Maternal embryonic leucine zipper kinase...
Artikelnummer: G-HUFI01450.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €