Zu "K08540" wurden 52 Artikel gefunden!
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2,8-Bis(trifluoromethyl)quinoline-4-carboxylic Acid
Artikelnummer: Cay43066-1
An agonist of PXR and active metabolite of mefloquine, increases the levels of CYP3A4 in a reporter assay using HepG2 cells expressing human PXR (EC50 = 24 µM), induces the expression of mRNA encoding MDR1, CYP2B6, and CYP3A4 in LS 174T cells
| Schlagworte: | 4-Carboxymefloquine, Mefloquine Carboxylic Acid, 2,8-bis(trifluoromethyl)-4-quinolinecarboxylic acid |
| Anwendung: | PXR agonist, active mefloquine metabolite |
| CAS | 35853-50-0 |
| MW: | 309.17 D |
ab 112,00 €
12-keto Lithocholic Acid
Artikelnummer: Cay29547-5
12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA, Cay-20756, Cay-18231). Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Cay-20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol...
| Schlagworte: | 12-keto-LCA, 12-Oxolithocholic Acid, (3alpha,5beta)-3-hydroxy-12-oxo-cholan-24-oic acid |
| Anwendung: | DCA metabolite, human pregnane X receptor agonist |
| CAS | 5130-29-0 |
| MW: | 390.6 D |
ab 116,00 €
Pregnenolone Carbonitrile
Artikelnummer: Cay16343-25
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...
| Schlagworte: | PCN, Pregnenolone 16alpha-carbonitrile, SC-4674, 3beta-hydroxy-20-oxo-pregn-5-ene-16alpha-carbonitrile |
| Anwendung: | Rodent pregnane X receptor (PXR) agonist |
| CAS | 1434-54-4 |
| MW: | 341.5 D |
ab 64,00 €
PXR (human) Reporter Assay Kit
Artikelnummer: IB-IB07001-32
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Schlagworte: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
Trabectedin
Artikelnummer: Cay34662-1
Trabectedin is an alkaloid that has been found in E. turbinata and has anticancer activity. It is a guanine-specific DNA alkylating agent and an antagonist of the pregnane X receptor (PXR, IC50 = ~3 nM in a reporter assay). Trabectedin reduces viability of DU145 and PC3 human prostate cancer stem cells in a...
| Schlagworte: | Ecteinascidin 743, ET-743, NSC 648766,... |
| Anwendung: | Alkaloid, anticancer agent, PXT antagonist, guanine-specific DNA alkylating agent |
| CAS | 114899-77-3 |
| MW: | 761.8 D |
ab 287,00 €
Anti-PXR, Internal
Artikelnummer: ARG64848.100
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Schlagworte: | Anti-PXR, Anti-SXR, Anti-NR1I2, Anti-Pregnane X receptor, Anti-Orphan nuclear receptor PXR, Anti-Orphan nuclear receptor... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Human PXR / NR1I2 ELISA Kit
Artikelnummer: G-HUFI00939.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Mouse PXR / NR1I2 ELISA Kit
Artikelnummer: G-MOFI00332.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Anti-NR1I2
Artikelnummer: NSJ-R33931-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Nuclear receptor subfamily 1, group I, member 2 Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that...
| Schlagworte: | Anti-PXR, Anti-SXR, Anti-NR1I2, Anti-Pregnane X receptor, Anti-Orphan nuclear receptor PXR, Anti-Orphan nuclear receptor... |
| Anwendung: | WB, IHC (paraffin), ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
PXR (Rat) Reporter Assay System
Artikelnummer: IB-R07001
Protein function: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific...
| Schlagworte: | Pxr, Nr1i2, Pregnane X receptor, Orphan nuclear receptor PXR, Nuclear receptor subfamily 1 group I member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | rat |
ab 1.588,00 €
Schisandrol B
Artikelnummer: Cay25149-1
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also...
| Schlagworte: | Besigomsin, Gomisin A, Wuweizichun B,... |
| Anwendung: | Hepatoprotective lignan |
| CAS | 58546-54-6 |
| MW: | 416.5 D |
ab 49,00 €
Human PXR (Pregnane X Receptor) CLIA Kit
Artikelnummer: G-HUES01264.96
ELISA Type: CLIA. Sensitivity: 18.75 pg/mL. Range: 31.25--2000 pg/mL. Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially...
| Schlagworte: | PXR, SXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | CLIA |
| Spezies-Reaktivität: | human |
641,00 €