Zu "K08536" wurden 70 Artikel gefunden!
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Anti-NR1H3 / Oxysterols receptor LXR-alpha
Artikelnummer: NSJ-FY13156
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NR1H3 antibody detects Oxysterols receptor LXR-alpha, a nuclear receptor that regulates lipid metabolism, inflammation, and cholesterol homeostasis. The UniProt recommended name is Oxysterols receptor LXR-alpha (NR1H3). This transcription...
| Schlagworte: | Anti-NR1H3, Anti-Liver X receptor alpha, Anti-Oxysterols receptor LXR-alpha, Anti-Nuclear receptor subfamily 1 group H... |
| Anwendung: | WB, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
GW 3965 (hydrochloride)
Artikelnummer: Cay10054-1
The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...
| Schlagworte: | 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 405911-17-3 |
| MW: | 618.5 D |
ab 38,00 €
25(S)-27-hydroxy Cholesterol
Artikelnummer: Cay14791-1
The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
| Schlagworte: | (25S)-26-hydroxy cholesterol, (25S)-cholest-5-ene-3beta,26-diol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 56845-83-1 |
| MW: | 402.7 D |
ab 85,00 €
T0901317
Artikelnummer: Cay71810-50
The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...
| Schlagworte: | N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide |
| Anwendung: | LXRalpha agonist, LXRbeta agonist |
| CAS | 293754-55-9 |
| MW: | 481.3 D |
ab 68,00 €
IMB-808
Artikelnummer: Cay42448-10
An agonist of LXRalpha and LXRbeta, induces transactivation of LXRalpha and LXRbeta in reporter assays using HEK293T cells (EC50s = 0.15 and 0.53 µM, respectively), increases protein levels of ABCG1 and ABCA1 in RAW 264.7 and THP-1 cells at 1 or 10 µM, induces cholesterol efflux and reduces oxidized LDL-induced...
| Schlagworte: | 2,3-dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-1,4-benzodioxin-6-carboxamide |
| Anwendung: | LXRalpha / LXRbeta agonist |
| CAS | 870768-70-0 |
| MW: | 380.32 D |
ab 107,00 €
SR9238
Artikelnummer: Cay18771-1
The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRalpha and LXRbeta (IC50s = 214 and 43 nM, respectively). It displays liver...
| Schlagworte: | 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic... |
| Anwendung: | LXRA / LXRB inverse agonist |
| CAS | 1416153-62-2 |
| MW: | 595.7 D |
ab 50,00 €
25(R)-27-hydroxy Cholesterol
Artikelnummer: Cay14790-5
The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
| Schlagworte: | (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol |
| Anwendung: | LXR alpha / beta activator |
| CAS | 20380-11-4 |
| MW: | 402.7 D |
ab 85,00 €
24(R)-hydroxy Cholesterol
Artikelnummer: Cay10217-1
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis. 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRalpha and LXRbeta...
| Schlagworte: | 24-Epicerebrosterol, cholest-5-ene-3beta,24R-diol |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 27460-26-0 |
| MW: | 402.7 D |
ab 73,00 €
GSK2033
Artikelnummer: Cay25443-1
GSK2033 is an antagonist of liver X receptor alpha (LXRalpha) and LXRbeta (IC50s = 0.1 and 0.398 µM, respectively) that has no agonist activity in an LXR transactivation assay. It inhibits LXR agonist-induced and basal expression of the LXR target genes ATP-binding cassette transporter 1 (ABCA1) and sterol...
| Schlagworte: | 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfo... |
| Anwendung: | LXRalpha / LXRbeta antagonist |
| CAS | 1221277-90-2 |
| MW: | 591.7 D |
ab 49,00 €
24(S)-hydroxy Cholesterol
Artikelnummer: Cay10009931-5
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further...
| Schlagworte: | Cerebrosterol, cholest-5-ene-3beta,24S-diol |
| Anwendung: | LXR alpha / beta agonist |
| CAS | 474-73-7 |
| MW: | 402.7 D |
ab 102,00 €
LXR-623
Artikelnummer: Cay21117-1
LXR-623 is a liver X receptor (LXR) modulator that acts as a partial agonist at LXRalpha and a full agonist at LXRbeta (IC50s = 179 and 24 nM, respectively). It is orally bioavailable and readily passes the blood-brain barrier. LXR-623 is anti-atherogenic in animal models of atherosclerosis, showing synergistic...
| Schlagworte: | WAY-252623, 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole |
| Anwendung: | LXR agonist |
| CAS | 875787-07-8 |
| MW: | 422.8 D |
ab 49,00 €
T0901317
Artikelnummer: AG-CR1-2906-M010
White to off-white solid. Soluble in DMSO, DMF or ethanol (all 50mg/ml). Chemical. CAS: 293754-55-9. Formula: C17H12F9NO3S. MW: 481.3. T0901317 is a potent, cell permeable and selective agonist of LXRalpha and LXRbeta (EC50 of 50nM, Kd values are 7 and 22 nM for LXR-alpha and LXR-beta, respectively), results in...
| Schlagworte: | TO-901317, T 1317 |
| Anwendung: | Potent, cell permeable, selective LXRalpha / LXRbeta agonist |
| CAS | 293754-55-9 |
| MW: | 481,3 D |
ab 50,00 €