Zu "K08528" wurden 57 Artikel gefunden!

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Human RARb (Retinoic Acid Receptor Beta) ELISA Kit
Human RARb (Retinoic Acid Receptor Beta) ELISA Kit

Artikelnummer: ELK-ELK4436.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RARb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RARb. Next,...
Schlagworte: HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B...
Anwendung: ELISA
Spezies-Reaktivität: human
365,00 € ab 328,50 €
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all-trans Retinoic Acid
all-trans Retinoic Acid

Artikelnummer: Cay11017-50

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...
Schlagworte: atRA, NSC 122578, NSC 122758, RA, Vitamin A Acid,...
Anwendung: RAR / RXR ligand
CAS 302-79-4
MW: 300.4 D
ab 48,00 €
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Acitretin
Acitretin

Artikelnummer: Cay20853-10

Acitretin is a retinoid and an active metabolite of the retinoid etretinate (Cay-19878) that has antiproliferative activities. It binds to cellular retinoic acid binding protein I (CRABP-I) and CRABP-II (Kds = 3 and 15 nM, respectively, for the mouse recombinant proteins) but has low affinity for human recombinant...
Schlagworte: all-trans Acitretin, Ro 10-1670, Ro 10-1670/000,...
Anwendung: Etretinate metabolite, Antiproliferative agent, RAR agonist
CAS 55079-83-9
MW: 326.4 D
ab 43,00 €
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all-trans Retinoic Acid-d5
all-trans Retinoic Acid-d5

Artikelnummer: Cay25415-500

all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid (Cay-11017) by GC- or LC-MS. all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and...
Schlagworte: atRA-d5, RA-d5, Vitamin A Acid-d5,...
Anwendung: RAR / RXR ligand, protein synthesis inhibitor, GC-MS, LC-MS, internal standard
MW: 305.5 D
ab 287,00 €
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RARbeta (human) Reporter Assay Kit
RARbeta (human) Reporter Assay Kit

Artikelnummer: IB-IB02101

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
Schlagworte: HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B...
Anwendung: Functional activity screening
Spezies-Reaktivität: human
ab 1.448,00 €
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all-trans-Retinol, high purity
all-trans-Retinol, high purity

Artikelnummer: LKT-R1877.25

All-trans retinol is a diterpenoid component of vitamin A. This compound is an essential vitamin and is necessary for effective vision, skin health, and bone growth. Retinol and its metabolites bind retinoic acid receptors (RARs) and retinoid X receptors (RXRs), both of which have multiple isotypes and isoforms....
Schlagworte: Alphasterol, Retinol, Avitol, Vitamin A
Anwendung: Retinoic acid receptor (RAR) agonist
CAS 68-26-8
MW: 286.45 D
ab 113,00 €
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CD2665
CD2665

Artikelnummer: Cay16031-1

CD2665 is a selective retinoic acid receptor (RAR)beta and RARgamma antagonist (Kds = 110, 306, and > 2,250 nM for RARgamma, RARbeta, and RARalpha, respectively, with no binding at RXRalpha). At 10-7 M, it has been used to abrogate retinoic acid (Cay-11017)-induced antiproliferative and antidifferentiative effects...
Schlagworte: 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-benzoic acid
Anwendung: RAR beta / gamma antagonist
CAS 170355-78-9
MW: 486.6 D
ab 50,00 €
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RARbeta Reporter (Luc)-HEK293 Cell Line (ca.2x10(6) cells)
RARbeta Reporter (Luc)-HEK293 Cell Line (ca.2x10(6) cells)

Artikelnummer: BPS-60603

The RAR beta Reporter (Luc)-HEK293 cell line is designed for monitoring the activity of RARbeta. The RAR beta Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARbeta (accession...
Schlagworte: RAR beta, Retinoic acid receptor beta, RARB,
Anwendung: RARbeta reporter assays
2.719,00 €
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TTNPB
TTNPB

Artikelnummer: Cay16144-10

TTNPB is an analog of retinoic acid (Cay-11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM). TTNPB is used to study RAR...
Schlagworte: AGN 191183, Arotinoid Acid, Ro 13-7410,...
Anwendung: Retinoic acid receptor agonist
CAS 71441-28-6
MW: 348.5 D
ab 60,00 €
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BMS 453
BMS 453

Artikelnummer: Cay19076-5

Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARbeta and an antagonist of RARalpha and RARgamma. It has been shown to inhibit the proliferation of normal breast cells via the...
Schlagworte: BMS 189453, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl], benzoic acid
Anwendung: RARbeta agonist, RARalpha / RARgamma antagonist
CAS 166977-43-1
MW: 380.5 D
ab 50,00 €
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all-trans-5,6-epoxy Retinoic Acid
all-trans-5,6-epoxy Retinoic Acid

Artikelnummer: Cay22124-500

all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR, EC50s = 77, 35, and 4 nM for RARalpha, RARbeta, and RARgamma, respectively). 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of...
Schlagworte: 5,6-epoxy RA, 5,6-epoxy-atRA, 5,6-epoxy-5,6-dihydro-retinoic acid
Anwendung: RAR agonist
CAS 13100-69-1
MW: 316.4 D
ab 246,00 €
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AGN 193109 (sodium salt)
AGN 193109 (sodium salt)

Artikelnummer: Cay23975-500

AGN 193109 is a potent antagonist of retinoic acid receptors (RARs, Kd = 2, 2, and 3 nM for RARalpha, beta, and gamma, respectively). It is selective for RARs over retinoid X receptors (RXRs, Kd = >10,000 nM for human RXRalpha, beta, and gamma receptors). AGN 193109 reverses changes in cell morphology induced by the...
Schlagworte: CD3106, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoic acid, monosodium salt
Anwendung: Retinoic acid receptor antagonist
CAS 2319838-82-7
MW: 414.5 D
ab 163,00 €
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