Zu "K08362" wurden 49 Artikel gefunden!
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3,3',5-Triiodo-L-thyronine (sodium salt hydrate)
Artikelnummer: Cay16028-100
3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRalpha and TRbeta (Kis = 2.3 nM for both) that modulates diverse biological properties, including...
| Schlagworte: | L-3,3',5-Triiodothyronine, Liothyronine, T3, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, monosodium salt, hydrate |
| Anwendung: | Thyroid hormone receptor agonist |
| CAS | 345957-19-9 |
| MW: | 673 D |
ab 73,00 €
Tiratricol
Artikelnummer: Cay28729-50
Tiratricol is a metabolite of 3,3',5-triiodo-L-thyronine (Cay-16028) and an agonist of the thyroid hormone receptors TRalpha and TRbeta (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays). In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in...
| Schlagworte: | 3,3',5-Triiodothyroacetic acid, 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-benzeneacetic acid |
| Anwendung: | Thyroid hormone receptor agonist, T3 metabolite |
| CAS | 51-24-1 |
| MW: | 621.9 D |
ab 49,00 €
Anti-Thyroid Hormone Receptor beta, clone 2386
Artikelnummer: 209-301-A96
Anti-Thyroid Hormone Receptor beta antibody is directed against human TR?. Thyroid Hormone Receptor beta antibody is purified by Protein G chromatography. This antibody is specific for the human protein. Cross reactivity from other sources has not been determined. Protein function: High affinity receptor for...
| Schlagworte: | Anti-THRB, Anti-ERBA2, Anti-c-erbA-2, Anti-c-erbA-beta, Anti-Thyroid hormone receptor beta, Anti-Nuclear receptor... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
881,00 €
MGL-3196
Artikelnummer: Cay23845-1
MGL-3196 is an agonist of thyroid hormone receptor beta (TRbeta, EC50s = 0.21 and 3.74 µM for TRbeta and TRalpha, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 µM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced...
| Schlagworte: | 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triaz... |
| Anwendung: | Thyroid hormone receptor beta agonist |
| CAS | 920509-32-6 |
| MW: | 435.2 D |
ab 42,00 €
3,5-Diiodo-L-thyronine
Artikelnummer: Cay35212-1
3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite. It binds to thyroid hormone receptor alpha1 (TRalpha1), TRbeta1, and TRbeta2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays). 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism...
| Schlagworte: | 3,5-Diiodothyronine, 3,5-T2, NSC 90469, O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine |
| Anwendung: | Thyroid hormone metabolite |
| CAS | 1041-01-6 |
| MW: | 525.1 D |
ab 85,00 €
Sobetirome
Artikelnummer: Cay30814-1
Sobetirome is an agonist of thyroid hormone receptor beta (TRbeta, EC50 = 7 nM in a reporter assay). It selectively binds to TRbeta over TRalpha with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of...
| Schlagworte: | GC-1, QRX 431, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-acetic acid |
| Anwendung: | Thyroid hormone receptor beta (Trbeta) agonist |
| CAS | 211110-63-3 |
| MW: | 328.4 D |
ab 58,00 €
Resmetirom
Artikelnummer: TGM-T3595-1mg
Description: Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor beta (THR-beta) agonist. Target: Thyroid hormone receptor(THR). Smiles: CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O. References: Kelly, M., Pietranico-Cole, S., Larigan, J., Haynes, N., Reynolds, C., & Scott, N. et al....
| Schlagworte: | MGL3196, VIA-3196 |
| Anwendung: | Targets thyroid hormone receptor beta (THRB, NR1A2) |
| CAS | 920509-32-6 |
| MW: | 435.22 D |
ab 32,00 €
L-Thyroxine
Artikelnummer: Cay14116-5
L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 µg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone (Cay-22917) from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS)...
| Schlagworte: | L-T4, Levothyroxine, NSC 36397, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine |
| Anwendung: | Thyroid hormone receptor agonist |
| CAS | 51-48-9 |
| MW: | 776.9 D |
ab 67,00 €
3,3',5-Triiodo-L-thyronine
Artikelnummer: Cay30996-250
3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRalpha and TRbeta (Kis = 2.3 nM for both) that modulates diverse biological properties, including...
| Schlagworte: | L-3,3',5-Triiodothyronine, Liothyronine, NSC 80203, T3, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine |
| Anwendung: | Thyroid hormone |
| CAS | 6893-02-3 |
| MW: | 651 D |
ab 111,00 €
TRbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB01102
This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor beta (NR1A2), a ligand-dependent transcription factor commonly referred to as TRbeta. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | THRB, ERBA2, c-erbA-2, c-erbA-beta, Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
4.175,00 €
![Anti-Thyroid Hormone Receptor beta1 (THRB1) [Rabbit]](https://www.biomol.com/media/image/39/29/7d/600-401-A96_200x200.jpg "Anti-Thyroid Hormone Receptor beta1 (THRB1) [Rabbit]")
Anti-Thyroid Hormone Receptor beta1 (THRB1) [Rabbit]
Artikelnummer: 600-401-A96
Protein function: High affinity receptor for triiodothyronine. [The UniProt Consortium]
| Schlagworte: | Anti-THRB, Anti-ERBA2, Anti-c-erbA-2, Anti-c-erbA-beta, Anti-Thyroid hormone receptor beta, Anti-Nuclear receptor... |
| Anwendung: | ELISA, IFM, IP, WB |
ab 180,00 €
Anti-Zebrafish Thrb
Artikelnummer: NSJ-R33481-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Protein function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is...
| Schlagworte: | Anti-TRb, Anti-thrb, Anti-nr1a2, Anti-TR-beta, Anti-TRbeta1, Anti-Thyroid hormone receptor beta, Anti-Thyroid hormone... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | zebrafish |
836,00 €