Zu "K08208" wurden 21 Artikel gefunden!
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Lesinurad
Artikelnummer: Cay23688-5
Lesinurad is an inhibitor of urate anion transporter 1 (URAT1, IC50s = 3.5 and 81 µM for human and rat transporters, respectively), a transporter that prevents renal urate resorption. It decreases uptake of urate by MDCK cells transfected with human URAT1. Lesinurad (80 mg/kg) also decreases serum levels of uric...
| Schlagworte: | 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid |
| Anwendung: | URAT1 inhibitor |
| CAS | 878672-00-5 |
| MW: | 404.3 D |
ab 85,00 €
Anti-SLC22A12 / URAT1
Artikelnummer: ARG40381.100
Protein function: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. [The UniProt Consortium]
| Schlagworte: | Anti-RST, Anti-OATL4, Anti-SLC22A12, Anti-Urate anion exchanger 1, Anti-Renal-specific transporter, Anti-Solute carrier... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
658,00 €
Verinurad
Artikelnummer: Cay29667-10
Verinurad is an inhibitor of urate anion transporter 1 (URAT1, IC50 = 0.025 µM for the human transporter). It is selective for human URAT1 over rat URAT1 (IC50 = 41 µM), as well as human organic anion transporter 1 (OAT1) and OAT4 (IC50s = 4.6 and 5.9 µM, respectively).Formal Name:...
| Schlagworte: | 2-[[3-(4-cyano-1-naphthalenyl)-4-pyridinyl]thio]-2-methyl-propanoic acid |
| Anwendung: | URAT1 inhibitor |
| CAS | 1352792-74-5 |
| MW: | 348.4 D |
ab 56,00 €
Benzarone
Artikelnummer: Cay34903-1
Benzarone is an active metabolite of the urate anion transporter 1 (URAT1) inhibitor benzbromarone (Cay-19768). It inhibits URAT1 in Xenopus oocytes expressing the human enzyme (IC50 = 2.8 µM). Benzarone also inhibits the tyrosine phosphatase activity of eyes absent homolog 3 (EYA3, IC50 = 17.5 µM), as well as...
| Schlagworte: | L 2197, NSC 82134, (2-ethyl-3-benzofuranyl)(4-hydroxyphenyl)-methanone |
| Anwendung: | Benzbromarone active metabolite |
| CAS | 1477-19-6 |
| MW: | 266.3 D |
ab 67,00 €
Anti-SLC22A12
Artikelnummer: ATA-HPA024575.100
Protein function: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest...
| Schlagworte: | Anti-RST, Anti-OATL4, Anti-SLC22A12, Anti-Urate anion exchanger 1, Anti-Renal-specific transporter, Anti-Solute carrier... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
Anti-SLC22A12
Artikelnummer: CSB-PA041473.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SLC22A12. Antigen Species: Human
| Schlagworte: | Anti-RST, Anti-OATL4, Anti-SLC22A12, Anti-Urate anion exchanger 1, Anti-Renal-specific transporter, Anti-Solute carrier... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Dotinurad
Artikelnummer: Cay41014-5
Dotinurad is a urate transporter 1 (URAT1) antagonist (IC50 = 0.0372 µM). It is selective for URAT1 over ATP-binding cassette subfamily G member 2 (ABCG2), organic anion transporter 1 (OAT1), and OAT3 (IC50s = 4.16, 4.08, and 1.32 µM, respectively). In vivo, dotinurad (30 mg/kg) decreases plasma levels of urate and...
| Schlagworte: | FYU-981, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-methanone |
| Anwendung: | URAT1 antagonist |
| CAS | 1285572-51-1 |
| MW: | 358.2 D |
483,00 €
URAT1 inhibitor 1
Artikelnummer: TGM-T13259-100mg
Description: URAT1 inhibitor 1 (1g) is a potent inhibitor of uric acid transporter 1 (URAT1) with an IC50 of 32 nM, and has potential therapeutic applications for treating hyperuricemia associated with gout. Target: OAT. Smiles: Brc1nnc(SCS(=O)(=O)Nc2cccnc2)n1Cc1ccc(Br)c2ccccc12. References: Wu JW, et al. Synthesis,...
| Anwendung: | URAT1 inhibitor |
| CAS | 2268720-62-1 |
| MW: | 569.29 D |
ab 1.535,00 €
Benzbromarone
Artikelnummer: TGM-T1274-100mg
Description: Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM. Target: Xanthine Oxidase, Apoptosis, P450. Smiles: C(=O)(C=1C=2C(OC1CC)=CC=CC2)C3=CC(Br)=C(O)C(Br)=C3. References: Locuson CW 2nd, et al. Drug Metab Dispos, 2003, 31(7), 967-971.
| Schlagworte: | Desuric, Normurat, Urinorm |
| Anwendung: | Targets SLC22A12 (URAT1) |
| CAS | 3562-84-3 |
| MW: | 424.08 D |
ab 32,00 €
Benzarone
Artikelnummer: TGM-T20545-1g
Description: Benzarone (Benzarona) is a potent inhibitor of human uric acid transporter 1 (URAT1, IC50 = 2.8 µM in oocyte). Benzarone lowers the level of uric acid serum. Target: OAT. Smiles: CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1. References: Kaufmann P, Török M, Hänni A, Roberts P, Gasser R, Krähenbühl S. Mechanisms of...
| Schlagworte: | Benzaronum, Vasoc, Benzarona, Venagil |
| Anwendung: | Benzbromarone active metabolite |
| CAS | 1477-19-6 |
| MW: | 266.29 D |
ab 29,00 €
URAT1 inhibitor 4
Artikelnummer: TGM-T72632-100mg
Description: URAT1 Inhibitor 4, derived from Lesinurad, is a potent, orally active inhibitor of URAT1 with an IC50 value of 7.56 µM, demonstrating greater in vivo urate-lowering efficacy than Lesinurad [1]. Target: Others. Smiles: S(CC(NS(=O)(=O)C1=CC=C(Br)C=C1)=O)C=2N(C(=O)C3=C(N2)SC=C3)C=4C5=C(C(=CC4)C6CC6)C=CC=C5
| Anwendung: | URAT1 inhibitor |
| CAS | 2700292-02-8 |
| MW: | 626.56 D |
ab 1.440,00 €
URAT1 inhibitor 7
Artikelnummer: TGM-T77517-100mg
Description: URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 µM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout. Target: OAT. Smiles:...
| Anwendung: | URAT1 inhibitor |
| CAS | 1632002-28-8 |
| MW: | 428.82 D |
ab 183,00 €