Zu "K07440" wurden 15 Artikel gefunden!
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Soticlestat
Artikelnummer: Cay34928-1
Soticlestat is an inhibitor of cholesterol 24-hydroxylase/CYP46A1 (IC50 = 0.0074 µM). It is selective for cholesterol 24-hydroxylase/CYP46A1 over the cytochrome P450 (CYP) isoforms CYP2C8, -2C9, -2D6, -3A4, -1A2, and 2C19 (IC50s = 62, 19, >100, 66, >100, and 14 µM, respectively). Soticlestat (0.02% in the diet)...
| Schlagworte: | OV935, TAK-935, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-methanone |
| Anwendung: | Cholesterol 24-hydroxylase/CYP46A1 inhibitor |
| CAS | 1429505-03-2 |
| MW: | 373.4 D |
ab 77,00 €
Human CYP46A1 (Cytochrome P450 46A1) ELISA Kit
Artikelnummer: ELK-ELK5356.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CYP46A1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CYP46A1....
| Schlagworte: | CYP46, CH24H, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, Cholesterol 24S-hydroxylase, Cholesterol 24-monooxygenase |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Anti-CYP46A1
Artikelnummer: CSB-PA565667.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CYP46A1. Antigen Species: Human
| Schlagworte: | Anti-CH24H, Anti-CYP46, Anti-Cytochrome P450 46A1, Anti-Cholesterol 24-hydroxylase, Anti-Cholesterol 24S-hydroxylase,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-CYP46A1
Artikelnummer: CSB-PA937671.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CYP46A1. Antigen Species: Human
| Schlagworte: | Anti-CH24H, Anti-CYP46, Anti-Cytochrome P450 46A1, Anti-Cholesterol 24-hydroxylase, Anti-Cholesterol 24S-hydroxylase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Soticlestat
Artikelnummer: TGM-T8937-100mg
Description: Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. Target: P450. Smiles: OC1(Cc2ccccc2)CCN(CC1)C(=O)c1cccnc1-c1ccncc1. References: Toshiya Nishi, et al. Soticlestat, a novel cholesterol...
| Schlagworte: | TAK-935, OV935 |
| Anwendung: | Targets cholesterol 24-hydroxylase [EC:1.14.14.25] (CYP46A1) |
| CAS | 1429505-03-2 |
| MW: | 373.45 D |
ab 57,00 €
Human CYP46A1 (Cytochrome P450 46A1) ELISA Kit
Artikelnummer: G-AEKE09087.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CYP46A1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CYP46A1....
| Schlagworte: | CYP46A1, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, Cholesterol 24S-hydroxylase, Cholesterol 24-monooxygenase |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
694,00 €
CYP46A1 (human), recombinant protein
Artikelnummer: ABS-PP-12674-L.100
Protein function: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697,...
| Schlagworte: | Cholesterol 24-hydroxylase, CH24H, Cholesterol 24-monooxygenase, Cholesterol 24S-hydroxylase, Cytochrome P450 46A1,... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 12.5 kD |
ab 115,00 €
CYP46A1 (human), recombinant protein
Artikelnummer: ABS-PP-22269-L.100
Protein function: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697,...
| Schlagworte: | CH24H, CYP46, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, Cholesterol 24S-hydroxylase, Cholesterol 24-monooxygenase |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 31.5 kD |
ab 115,00 €
CYP46A1 (human), recombinant protein
Artikelnummer: ABS-PP-22269.100
Protein function: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697,...
| Schlagworte: | CH24H, CYP46, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, Cholesterol 24S-hydroxylase, Cholesterol 24-monooxygenase |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 31.5 kD |
ab 90,00 €
CYP46A1, Human cytochrome P450, family 46, subfamily A,...
Artikelnummer: VHPS-2411
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | CYP46, CH24H, CYP46A1, EC=1.14.13.98, Cytochrome P450 46A1, Cholesterol 24-hydroxylase |
| Anwendung: | RNA quantification |
45,00 €
Cyp46A1, Mouse cytochrome P450, family 46, subfamily a,...
Artikelnummer: VMPS-1525
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Cyp46, CH24H, Cyp46a1, EC=1.14.13.98, Cytochrome P450 46A1, Cholesterol 24-hydroxylase |
| Anwendung: | RNA quantification |
45,00 €
Anti-CYP46A1
Artikelnummer: G-CAB8573.20
Protein function: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697,...
| Schlagworte: | Anti-CH24H, Anti-CYP46, Anti-Cytochrome P450 46A1, Anti-Cholesterol 24-hydroxylase, Anti-Cholesterol 24S-hydroxylase,... |
| Anwendung: | WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
103,00 €