Zu "K07376" wurden 57 Artikel gefunden!
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KT 5823
Artikelnummer: Cay10010965-100
The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM). KT 5823 is...
| Schlagworte: | 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]b... |
| Anwendung: | PKG inhibitor |
| CAS | 126643-37-6 |
| MW: | 495.5 D |
ab 56,00 €
8-bromo Cyclic GMP (sodium salt)
Artikelnummer: Cay15992-5
8-bromo Cyclic GMP (8-bromo cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 µM-0.1 mM, 8-bromo cGMP can inhibit acetylcholine-induced increases in intracellular...
| Schlagworte: | 8-bromo-cGMP, 8-bromo Guanosine 3',5'-cyclic monophosphate, 8-bromo-guanosine cyclic 3',5'-(hydrogen phosphate),... |
| Anwendung: | Cell-permeable cGMP analog, PRKG activator |
| CAS | 51116-01-9 |
| MW: | 447.1 D |
ab 67,00 €
KT5823
Artikelnummer: LKT-K7602.100
A K252 derivitive.
| Anwendung: | PKG inhibitor |
| CAS | 126643-37-6 |
| MW: | 481,16 D |
ab 406,00 €
PKG Inhibitor
Artikelnummer: Cay15995-1
PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 µM). This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B. PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced...
| Schlagworte: | Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid, Protein Kinase G Inhibitor,... |
| Anwendung: | cGMP-dependent protein kinase (PKG) inhibitor |
| CAS | 82801-73-8 |
| MW: | 943.1 D |
ab 85,00 €
HA-100 (hydrochloride)
Artikelnummer: Cay14955-10
HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 µM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC50 = 240 µM).Formal Name:...
| Schlagworte: | C-1, 5-(1-piperazinylsulfonyl)-isoquinoline, dihydrochloride |
| Anwendung: | Protein kinase inhbitor |
| CAS | 210297-47-5 |
| MW: | 350.3 D |
ab 95,00 €
Dibutyryl-Cyclic GMP (sodium salt)
Artikelnummer: Cay15991-50
Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase. It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.Formal Name: N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate)...
| Schlagworte: | Dibutyryl Guanosine 3',5'-cyclic monophosphate, Dibutyryl-cGMP, N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate)... |
| Anwendung: | Cell-permeable cGMP analog, cGMP-dependent protein kinase activator |
| CAS | 51116-00-8 |
| MW: | 507.4 D |
ab 100,00 €
PKG1 alpha, cGMP dependent, human recombinant, N-terminal...
Artikelnummer: BPS-40082
cGMP dependent Human PKG1alpha (GenBank Accession No. NM_001098512), full length with N-terminal His tag, MW = 80 kDa, expressed in Baculovirus infected Sf9 cell expression system. Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EGTA, 200 µM ATP, 0.01% Brij-35, and 2 µM...
| Schlagworte: | cGKI, cGK1, PRKG1, cGK 1, PRKG1B, EC=2.7.11.12, cGMP-dependent protein kinase 1, cGMP-dependent protein kinase I, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 80 kD |
536,00 €
PKG1beta, active human recombinant protein
Artikelnummer: BPS-40083
Active human PKG1beta (GenBank Accession No. NM_006258), full length with N-terminal His tag, MW = 78 kDa, expressed in Baculovirus infected Sf9 cell expression system.
| Schlagworte: | cGKI, cGK1, PRKG1, cGK 1, PRKG1B, EC=2.7.11.12, cGMP-dependent protein kinase 1, cGMP-dependent protein kinase I, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 78 kD |
536,00 €
Cyclic GMP (sodium salt)
Artikelnummer: Cay18821-250
Cyclic GMP (cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides. cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth...
| Schlagworte: | cGMP, Cyclic guanosine monophosphate, Guanosine 3'5'-cyclic monophosphate, Monosodium-GMP, cyclic 3',5'-(hydrogen... |
| Anwendung: | PKG activator |
| CAS | 40732-48-7 |
| MW: | 367.2 D |
ab 93,00 €
Human PRKG1 ELISA Kit
Artikelnummer: G-HUFI02785.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Rp-8-bromo-PET-Cyclic GMPS (sodium salt)
Artikelnummer: Cay18823-1
Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 µM)...
| Schlagworte: | Rp-8-bromo-PET-cGMPS,... |
| Anwendung: | cGMP-dependent protein kinase inhibitor |
| CAS | 185246-32-6 |
| MW: | 562.3 D |
ab 397,00 €
Anti-cGKI beta
Artikelnummer: NSJ-F40166-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...
| Schlagworte: | Anti-cGKI, Anti-cGK1, Anti-PRKG1, Anti-cGK 1, Anti-PRKG1B, EC=2.7.11.12, Anti-cGMP-dependent protein kinase 1,... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 361,00 €