Zu "K07203" wurden 222 Artikel gefunden!
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Rapamycin
Artikelnummer: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Schlagworte: | AY 22989, NSC 226080, Wy 090217,... |
| Anwendung: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
ab 58,00 €
Torin 1
Artikelnummer: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Schlagworte: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Anwendung: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
ab 217,00 €
NEU
PI3K/Akt/mTOR-IN-2
Artikelnummer: Cay44655-10
PI3K/Akt/mTOR-IN-2 is an inhibitor of the PI3K/Akt/mTOR pathway. It reduces the phosphorylation of Akt and mTOR when used at a concentration of 2 µM and decreases PI3K, Akt, and mTOR levels at 4 µM. PI3K/Akt/mTOR-IN-2 is cytotoxic to A549, BGC-823, PC3, MCF-7, and MDA-MB-231 cancer cells (IC50s = 14. 9. 9. 7. and 2....
| Schlagworte: | Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Inhibitor 2, Phosphatidylinositol... |
| Anwendung: | PI3K/Akt/mTOR pathway inhibitor |
| CAS | 2757804-89-8 |
| MW: | 285.29 D |
ab 120,00 €
Anti-Recombinant mTOR, clone 4F10
Artikelnummer: E-AN301363L.100
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Mammalian target of rapamycin,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
391,00 €
Anti-mTOR / Mammalian target of rapamycin, clone 32M82
Artikelnummer: NSJ-FY12751
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. mTOR antibody detects mechanistic target of rapamycin, encoded by the MTOR gene. Common alternate names include FRAP1, RAFT1, and RAPT1. mTOR is a serine threonine kinase that integrates nutrient,...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Rapamycin and FKBP12 target 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-mTOR
Artikelnummer: NSJ-RQ5343
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. The protein encoded by this gene belongs to a...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Rapamycin and FKBP12 target 1,... |
| Anwendung: | WB, IHC (paraffin), Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, monkey |
790,00 €
Anti-phospho-mTOR (Ser2448), clone IFF-13
Artikelnummer: NSJ-RQ8814
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation...
| Schlagworte: | Anti-phospho-MTOR, Anti-phospho-Rapamycin target protein 1, Anti-phospho-Tyrosine-protein kinase mTOR,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Rapamycin
Artikelnummer: AG-CN2-0025-M001
Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...
| Schlagworte: | Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024 |
| Anwendung: | mTOR inhibitor, Immunsuppressant, Apoptosis inducer |
| CAS | 53123-88-9 |
| MW: | 914,2 D |
ab 28,00 €
LY3023414
Artikelnummer: Cay44438-10
LY3023414 is a dual inhibitor of PI3K and mTOR. It selectively inhibits PI3Kalpha, PI3Kbeta, and mTOR (IC50 = 83, 600, and 16 nM, respectively) over 283 other kinases at 20 µM but does inhibit DNA-dependent protein kinase (DNA-PK), ataxia-telangiectasia mutated kinase (ATM), the PI3K-related kinase SMG1, and...
| Schlagworte: | Samotolisib,... |
| Anwendung: | PI3K / mTOR dual inhibitor |
| CAS | 1386874-06-1 |
| MW: | 406,49 D |
ab 127,00 €
Everolimus
Artikelnummer: Cay11597-5
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that, as part of two distinct complexes (mTORC1 and mTORC2), plays pivotal roles in intracellular signaling. Everolimus is a hydroxyethyl ether rapamycin (Cay-13346) derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added...
| Schlagworte: | RAD001, 42-O-(2-hydroxyethyl)-rapamycin |
| Anwendung: | mTOR inhibitor |
| CAS | 159351-69-6 |
| MW: | 958.2 D |
ab 73,00 €
Anti-Phospho-mTOR (Ser2448) Monoclonal Recombinant Antibody
Artikelnummer: E-AN300143L.100
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin...
| Schlagworte: | FRAP, mTOR, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, Mammalian target of rapamycin, Rapamycin and FKBP12... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Rapamycin
Artikelnummer: LKT-R0161.1
Macrolide originally produced by Streptomyces, mTOR inhibitor.
| Schlagworte: | Sirolimus, Rapamune, AY-22989 |
| Anwendung: | Antibiotic |
| CAS | 53123-88-9 |
| MW: | 914,17 D |
ab 67,00 €