Zu "K07203" wurden 249 Artikel gefunden!
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Rapamycin
Artikelnummer: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Schlagworte: | AY 22989, NSC 226080, Wy 090217,... |
| Anwendung: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
ab 60,00 €
Torin 1
Artikelnummer: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Schlagworte: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Anwendung: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
ab 224,00 €
NEU
Human MTOR (Serine/threonine-protein kinase mTOR)...
Artikelnummer: ELK-ELK9237MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MTOR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MTOR. Next,...
| Schlagworte: | MTOR, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, Rapamycin and FKBP12 target 1, Mammalian target of... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
NEU
Mouse mTOR (Serine/threonine-protein kinase mTOR)...
Artikelnummer: ELK-ELK8644MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse MTOR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MTOR. Next,...
| Schlagworte: | Mtor, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, Mammalian target of rapamycin, Mechanistic target of... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 374,00 €
NEU
Human mTOR (MammalianTarget of Rapamycin) Microsample...
Artikelnummer: ELK-ELK9591MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human mTOR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human mTOR. Next,...
| Schlagworte: | MTOR, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, Rapamycin and FKBP12 target 1, Mammalian target of... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
NEU
Mouse FRAP (FK506 Binding Protein 12 Rapamycin Associated...
Artikelnummer: ELK-ELK8589MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse FRAP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse FRAP. Next,...
| Schlagworte: | Mtor, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, Mammalian target of rapamycin, Mechanistic target of... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 374,00 €
Anti-mTOR
Artikelnummer: NSJ-F49548-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. FRAP1/mTOR belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Mammalian target of rapamycin,... |
| Anwendung: | WB, IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
Rapamycin
Artikelnummer: AG-CN2-0025-M001
Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...
| Schlagworte: | Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024 |
| Anwendung: | mTOR inhibitor, Immunsuppressant, Apoptosis inducer |
| CAS | 53123-88-9 |
| MW: | 914,2 D |
ab 28,00 €
PI3K/Akt/mTOR-IN-2
Artikelnummer: Cay44655-10
PI3K/Akt/mTOR-IN-2 is an inhibitor of the PI3K/Akt/mTOR pathway. It reduces the phosphorylation of Akt and mTOR when used at a concentration of 2 µM and decreases PI3K, Akt, and mTOR levels at 4 µM. PI3K/Akt/mTOR-IN-2 is cytotoxic to A549, BGC-823, PC3, MCF-7, and MDA-MB-231 cancer cells (IC50s = 14. 9. 9. 7. and 2....
| Schlagworte: | Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Inhibitor 2, Phosphatidylinositol... |
| Anwendung: | PI3K/Akt/mTOR pathway inhibitor |
| CAS | 2757804-89-8 |
| MW: | 285.29 D |
ab 124,00 €
Anti-Recombinant mTOR, clone 4F10
Artikelnummer: E-AN301363L.100
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Mammalian target of rapamycin,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
389,00 €
Anti-mTOR / Mammalian target of rapamycin, clone 32M82
Artikelnummer: NSJ-FY12751
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. mTOR antibody detects mechanistic target of rapamycin, encoded by the MTOR gene. Common alternate names include FRAP1, RAFT1, and RAPT1. mTOR is a serine threonine kinase that integrates nutrient,...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Rapamycin and FKBP12 target 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-mTOR
Artikelnummer: NSJ-RQ5343
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. The protein encoded by this gene belongs to a...
| Schlagworte: | Anti-MTOR, Anti-Rapamycin target protein 1, Anti-Tyrosine-protein kinase mTOR, Anti-Rapamycin and FKBP12 target 1,... |
| Anwendung: | WB, IHC (paraffin), Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, monkey |
790,00 €