Zu "K07203" wurden 163 Artikel gefunden!
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Torin 1 Artikelnummer: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Schlagworte: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Anwendung: | MTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
ab 150,00 €
Rapamycin Artikelnummer: AG-CN2-0025-M001
Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...
| Schlagworte: | Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024 |
| Anwendung: | MTOR inhibitor, Immunsuppressant, Apoptosis inducer |
| CAS | 53123-88-9 |
| MW: | 914,2 D |
ab 28,00 €
Rapamycin Artikelnummer: Cay13346-1
Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12)...
| Schlagworte: | Sirolimus,... |
| Anwendung: | MTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
ab 37,00 €
Everolimus Artikelnummer: Cay11597-5
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that, as part of two distinct complexes (mTORC1 and mTORC2), plays pivotal roles in intracellular signaling. Everolimus is a hydroxyethyl ether rapamycin (Cay-13346) derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added...
| Schlagworte: | Afinitor(R), Certican, NVP-RAD001, RAD001, 42-O-(2-hydroxyethyl)-rapamycin |
| Anwendung: | MTOR inhibitor |
| CAS | 159351-69-6 |
| MW: | 958.2 D |
ab 82,00 €
INK128 Artikelnummer: Cay11811-1
INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM). It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2. INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors. Moreover, daily, oral...
| Schlagworte: | MLN0128, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | TORC1/2 inhibitor |
| CAS | 1224844-38-5 |
| MW: | 309.3 D |
ab 30,00 €
Rapamycin Artikelnummer: LKT-R0161.10
An antifungal antibiotic that has immunosuppressive activity. It blocks cytokine-mediated signal transduction pathways.
| Schlagworte: | Sirolimus |
| Anwendung: | Antibiotic |
| CAS | 53123-88-9 |
| MW: | 914,17 D |
ab 48,00 €
Torin 2 Artikelnummer: Cay14185-5
Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM). It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases. Torin 2 has significantly improved bioavailability (54%), metabolic...
| Schlagworte: | 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Anwendung: | MTOR inhibitor |
| CAS | 1223001-51-1 |
| MW: | 432.4 D |
ab 87,00 €
OSI-027 Artikelnummer: Cay17379-1
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin (Cay-13346)) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of...
| Schlagworte: | trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid |
| Anwendung: | MTORC1 / mTORC2 inhibitor |
| CAS | 936890-98-1 |
| MW: | 406.4 D |
ab 37,00 €
Rapamycin (FRAP, mTOR Inhibitor) Artikelnummer: R1137-01.10
Rapamycin is a bacterial macrolide with antifungal and immunosuppressant activities , (1). Rapamycin forms a complex with the immunophilin FKBP12 which then inhibits the activity of FRAP/mTOR (TOR in yeast) (2,3). Rapamycin treatment of cells leads to the dephosphorylation and inactivation of p70 S6 kinase....
| CAS | 53123-88-9 |
| MW: | 914.20 D |
ab 98,00 €
Ku-0063794 Artikelnummer: Cay13597-5
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and...
| Schlagworte: | rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol |
| Anwendung: | TORC1/2 inhibitor |
| CAS | 938440-64-3 |
| MW: | 465.5 D |
ab 74,00 €
AZD 8055 Artikelnummer: Cay16978-1
AZD 8055 is a potent, selective ATP-competitive inhibitor of mTOR, exhibiting an IC50 value of 0.8 nM. It is ~1,000-fold selective for mTOR over all PI3K isoforms and exhibits no activity against a panel of 260 kinases at concentrations up to 10 µM. AZD 8055 inhibits proliferation of A549 and H838 cells with IC50...
| Schlagworte: | CCG-168, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol |
| Anwendung: | MTOR inhibitor |
| CAS | 1009298-09-2 |
| MW: | 465.5 D |
ab 44,00 €
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Anti-phospho-mTOR (Ser2448) (mTAb1, Mammalian Target of... Artikelnummer: 600-401-422
Protein function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1...
| Schlagworte: | Anti-phospho-mTOR, Anti-phospho-FRAP, Anti-phospho-MTOR, EC=2.7.11.1, Anti-phospho-Rapamycin target protein 1,... |
| Anwendung: | WB, ELISA, IHC |
| Reaktivität: | Human |
493,00 €