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Zu "K07203" wurden 172 Artikel gefunden!
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Artikelnummer: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
Schlagworte: | AY 22989, NSC 226080, Wy 090217,... |
Anwendung: | mTORC1 blocking |
CAS | 53123-88-9 |
MW: | 914.2 D |
ab 50,00 €
Artikelnummer: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
Schlagworte: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
Anwendung: | mTor inhibitor |
CAS | 1222998-36-8 |
MW: | 607.6 D |
ab 196,00 €
Artikelnummer: AG-CN2-0025-M001
Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...
Schlagworte: | Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024 |
Anwendung: | mTOR inhibitor, Immunsuppressant, Apoptosis inducer |
CAS | 53123-88-9 |
MW: | 914,2 D |
ab 28,00 €
Artikelnummer: ELK-ELK7584.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat FRAP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat FRAP. Next,...
Schlagworte: | mTOR, RAPT1, Frap1, Rapamycin target protein 1, Mammalian target of rapamycin, Mechanistic target of rapamycin,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: ELK-ELK8589.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse FRAP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse FRAP. Next,...
Schlagworte: | mTOR, Frap, RAPT1, Rapamycin target protein 1, Mammalian target of rapamycin, Mechanistic target of rapamycin,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: ELK-ELK8644.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse MTOR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MTOR. Next,...
Schlagworte: | mTOR, Frap, RAPT1, Rapamycin target protein 1, Mammalian target of rapamycin, Mechanistic target of rapamycin,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: ELK-ELK4316.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FRAP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FRAP. Next,...
Schlagworte: | mTOR, FRAP, Rapamycin target protein 1, Rapamycin and FKBP12 target 1, Mammalian target of rapamycin, Mechanistic target... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay15017-5
PF-04691502 is an inhibitor of PI3Kalpha, -beta, -delta, and -gamma and mammalian target of rapamycin (mTOR, Kis = 1.8, 2.1, 1.6, 1.9, and 16 nM, respectively, for the human enzymes). It decreases the proliferation of BT-20 breast cancer, SKOV3 ovarian cancer, and U87MG glioblastoma cells (IC50s = 313, 188, and 179...
Schlagworte: | HNC-VP-L, PF-502,... |
Anwendung: | PI3K/mTOR inhibitor |
CAS | 1013101-36-4 |
MW: | 425.5 D |
ab 119,00 €
Artikelnummer: Cay11597-5
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that, as part of two distinct complexes (mTORC1 and mTORC2), plays pivotal roles in intracellular signaling. Everolimus is a hydroxyethyl ether rapamycin (Cay-13346) derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added...
Schlagworte: | RAD001, 42-O-(2-hydroxyethyl)-rapamycin |
Anwendung: | mTOR inhibitor |
CAS | 159351-69-6 |
MW: | 958.2 D |
ab 66,00 €
Artikelnummer: LC-R-5000_50mg
Soluble in DMSO at 200 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
Schlagworte: | Sirolimus,... |
Anwendung: | mTORC1 blocking |
CAS | 53123-88-9 |
MW: | 914,17 D |
ab 93,00 €
Artikelnummer: Cay14185-5
Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM). It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases. Torin 2 has significantly improved bioavailability (54%), metabolic...
Schlagworte: | 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one |
Anwendung: | mTOR inhibitor |
CAS | 1223001-51-1 |
MW: | 432.4 D |
ab 115,00 €
Artikelnummer: LKT-R0161.10
Macrolide originally produced by Streptomyces, mTOR inhibitor.
Schlagworte: | Sirolimus, Rapamune, AY-22989 |
Anwendung: | Antibiotic |
CAS | 53123-88-9 |
MW: | 914,17 D |
ab 64,00 €