Zu "K06642" wurden 84 Artikel gefunden!
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Mouse PRKDC (Protein Kinase, DNA Activated, Catalytic...
Artikelnummer: ELK-ELK6651.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PRKDC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PRKDC. Next,...
| Schlagworte: | p460, Xrcc7, Prkdc, DNA-PKcs, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Anti-Phospho-DNA-PKcs (Ser2056) (human), Rabbit...
Artikelnummer: REV-31-1392-00-R100
DNA-dependent protein kinase (DNA-PK) is an important factor in the repair of double-stranded breaks in DNA. Cells lacking DNA-PK or in which DNA-PK is inhibited fail to show proper nonhomologous end-joining (NHEJ). DNA-PK is composed of two DNA-binding subunits (Ku70 and Ku86) and one 450 kDa catalytic subunit...
| Schlagworte: | Anti-phospho-p460, Anti-phospho-HYRC, Anti-phospho-DNPK1, Anti-phospho-PRKDC, Anti-phospho-DNA-PKcs, Anti-phospho-DNA-PK... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
483,00 €
Anti-DNA-PKcs (human), Rabbit Monoclonal (RM505)
Artikelnummer: REV-31-1397-00-R100
DNA-dependent protein kinase (DNA-PK) is an important factor in the repair of double-stranded breaks in DNA. Cells lacking DNA-PK or in which DNA-PK is inhibited fail to show proper nonhomologous end-joining (NHEJ). DNA-PK is composed of two DNA-binding subunits (Ku70 and Ku86) and one 450 kDa catalytic subunit...
| Schlagworte: | Anti-p460, Anti-HYRC, Anti-DNPK1, Anti-PRKDC, Anti-DNA-PKcs, Anti-DNA-PK catalytic subunit, Anti-DNA-dependent protein... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
483,00 €
NU 7026
Artikelnummer: Cay13308-5
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...
| Schlagworte: | DNA-PK Inhibitor II, LY293646, 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one |
| Anwendung: | DNA-PK inhibitor |
| CAS | 154447-35-5 |
| MW: | 281.3 D |
ab 109,00 €
NU 7441
Artikelnummer: Cay14881-1
DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to...
| Schlagworte: | Ku-57788, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| Anwendung: | DNA-PK inhibitor |
| CAS | 503468-95-9 |
| MW: | 413.5 D |
ab 36,00 €
Anti-DNA-PKcs
Artikelnummer: A300-519A
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA...
| Schlagworte: | Anti-p460, Anti-HYRC, Anti-DNPK1, Anti-PRKDC, Anti-DNA-PKcs, EC=2.7.11.1, Anti-DNA-PK catalytic subunit,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Bisindolylmaleimide VIII (acetate)
Artikelnummer: Cay13333-1
Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. This compound exhibits some degree of PKC isozyme specificity with preference for PKCalpha over PKCbetaI, PKCbetaII, PKCgamma, or PKCepsilon (IC50s = 53,...
| Schlagworte: | BIM VIII, Ro 31-7549, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, acetate |
| Anwendung: | PKC inhibitor |
| CAS | 138516-31-1 |
| MW: | 458.5 D |
ab 68,00 €
AZD 7648
Artikelnummer: Cay28598-1
AZD 7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK, IC50 = 0.63 nM in an enzyme assay). It is selective for DNA-PK over TTK (IC50 = 5.012 µM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 µM for all). AZD 7648 reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft...
| Schlagworte: | 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one |
| Anwendung: | DNA-PK inhibitor |
| CAS | 2230820-11-6 |
| MW: | 380.4 D |
ab 50,00 €
Anti-DNA-PKcs (IHC)
Artikelnummer: IHC-00044
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA...
| Schlagworte: | Anti-p460, Anti-HYRC, Anti-DNPK1, Anti-PRKDC, Anti-DNA-PKcs, EC=2.7.11.1, Anti-DNA-PK catalytic subunit,... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-phospho-DNA PKcs (Thr2609)
Artikelnummer: 600-401-494
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA...
| Schlagworte: | Anti-phospho-p460, Anti-phospho-HYRC, Anti-phospho-PRKDC, Anti-phospho-DNPK1, Anti-phospho-DNA-PKcs, EC=2.7.11.1,... |
| Anwendung: | ELISA, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
684,00 €
Ku-0060648
Artikelnummer: Cay15344-5
Ku-0060648 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and an inhibitor of PI3K. In a cell-free assay, it has IC50s of 5, 4, 0.5, 50s of 19 and 39 nM, for DNA-PK and PI3K, respectively, while in SW620 cells, it has an IC50 of 170 nM for DNA-PK but >10,000 nM for PI3K. Ku-0060648 is...
| Schlagworte: | 4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide |
| Anwendung: | Dual PI3K & DNA-PK inhibitor |
| CAS | 881375-00-4 |
| MW: | 582.7 D |
ab 50,00 €
CC-115
Artikelnummer: Cay19420-1
CC-115 is a dual inhibitor of mammalian target of rapamycin (mTOR) and DNA protein kinase (DNA-PK, IC50s = 0.021 and 0.013 µM, respectively). It is selective for mTOR and DNA-PK over PI3Kalpha, ATM, and ATR (IC50s = 0.85, >30, and >30 µM, respectively). CC-115 inhibits growth in a panel of 123 cancer cell lines,...
| Schlagworte: | 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1H)-one |
| Anwendung: | DNA-PK / mTOR inhibitor |
| CAS | 1228013-15-7 |
| MW: | 336.4 D |
ab 43,00 €