Zu "K06632" wurden 64 Artikel gefunden!
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Debio 0123 (hydrochloride)
Artikelnummer: Cay39674-1
Debio 0123 is an inhibitor of the checkpoint kinase WEE1 (IC50 = 0.8 nM). In vivo, debio 0123 (30 mg/kg per day), in combination with the inhibitor of topoisomerase II etoposide (Cay-12092), reduces tumor volume in a patient-derived xenograft (PDX) mouse model of stomach cancer.Formal Name:...
| Schlagworte: | WEE1 Inhibitor 5, WEE1-IN-5,... |
| Anwendung: | WEE1 inhibitor |
| MW: | 511.4 D |
ab 77,00 €
Adavosertib
Artikelnummer: TGM-T2077-100mg
Description: Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint. Target: Wee1. Smiles: C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C(C(C)(C)O)C=CC5. References: Hirai H, et al. Small-molecule inhibition of Wee1...
| Schlagworte: | MK-1775, AZD1775, Adavosertib (MK-1775) |
| Anwendung: | Targets wee1-like protein kinase [EC:2.7.11.1] (WEE1) |
| CAS | 955365-80-7 |
| MW: | 500.6 D |
ab 42,00 €
MK-1775
Artikelnummer: Cay21266-5
MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM). It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the G2 DNA damage checkpoint. In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging...
| Schlagworte: | AZD 1775,... |
| Anwendung: | Wee1 inhibitor |
| CAS | 955365-80-7 |
| MW: | 500.6 D |
ab 61,00 €
Anti-Phospho-WEE1 (S642)
Artikelnummer: CSB-PA060083.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-phospho-WEE1, Anti-phospho-WEE1hu, EC=2.7.10.2, Anti-phospho-Wee1A kinase, Anti-phospho-Wee1-like protein kinase,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-Phospho-WEE1 (Ser642)
Artikelnummer: CSB-PA062918.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-WEE1, Anti-phospho-WEE1hu, EC=2.7.10.2, Anti-phospho-Wee1A kinase, Anti-phospho-Wee1-like protein kinase,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
340,00 €
Wee1-like protein kinase (WEE1), human, recombinant
Artikelnummer: CSB-EP026084HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-646aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP GADEAGGGAE GDSWEEEGFG SSSPVKSPAA...
| Schlagworte: | WEE1, WEE1hu, EC=2.7.10.2, Wee1A kinase, Wee1-like protein kinase, Recombinant Human Wee1-like protein kinase (WEE1) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 77.6 kD |
ab 292,00 €
Wee1-like protein kinase (WEE1), human, recombinant
Artikelnummer: CSB-EP026084HUc7.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-646aa. Protein Length: Full Length. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP GADEAGGGAE GDSWEEEGFG SSSPVKSPAA...
| Schlagworte: | WEE1, WEE1hu, EC=2.7.10.2, Wee1A kinase, Wee1-like protein kinase, Recombinant Human Wee1-like protein kinase (WEE1) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 78.5 kD |
ab 292,00 €
Wee1-like protein kinase (Wee1), mouse, recombinant
Artikelnummer: CSB-EP026084MO.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-646aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MSFLSRQQPP PTRRVGAAYS LRQKLIFSPG SDCEEEEEEE EEGSGHSTGE DSAFQEPDSP LPSARSPAEA EAERRRRSPG AEPSSPGELE DDLLLQGGGG GAQAAGGGAE GDSWEEEGFG SSSPVKSPST...
| Schlagworte: | Wee1, EC=2.7.10.2, Wee1A kinase, Wee1-like protein kinase, Recombinant Mouse Wee1-like protein kinase (Wee1) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | mouse |
| MW: | 77.5 kD |
ab 364,00 €
Anti-WEE1
Artikelnummer: ARG55245.100
Protein function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed...
| Schlagworte: | Anti-WEE1, Anti-WEE1hu, EC=2.7.10.2, Anti-Wee1A kinase, Anti-Wee1-like protein kinase |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 432,00 €
Wee1, GST-Th-Tag
Artikelnummer: BPS-40412
Human Wee1 protein, also known as Wee1A Kinase, GenBank Accession No. NM_003390, amino acids 215-646 (end), with an N-terminal GST-Thrombin tag, expressed in a Baculovirus infected Sf9 cell expression system. MW = 75 kDa.
| Schlagworte: | WEE1, WEE1hu, EC=2.7.10.2, Wee1A kinase, Wee1-like protein kinase, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 75 kD |
566,00 €
Anti-Wee1
Artikelnummer: NSJ-F46995-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is...
| Schlagworte: | Anti-Wee1, EC=2.7.10.2, Anti-Wee1A kinase, Anti-Wee1-like protein kinase, Wee1 Antibody |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 350,00 €
Anti-phospho-Wee1 (Ser123)
Artikelnummer: NSJ-F48463-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and...
| Schlagworte: | Anti-phospho-WEE1, Anti-phospho-WEE1hu, EC=2.7.10.2, Anti-phospho-Wee1A kinase, Anti-phospho-Wee1-like protein kinase,... |
| Anwendung: | Dot Blot, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 350,00 €