Zu "K06631" wurden 79 Artikel gefunden!
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Anti-PLK1, clone 6D11
Artikelnummer: NSJ-RQ5512
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase1) gene. Plk1 is an early trigger for G2/M transition. It supports...
| Schlagworte: | Anti-PLK, Anti-PLK1, Anti-PLK-1, Anti-STPK13, Anti-Polo-like kinase 1, Anti-Serine/threonine-protein kinase 13,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat, monkey |
755,00 €
Anti-phospho-Plk1 (Ser137)
Artikelnummer: ELK-ES6618.100
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis, hence, it is a target...
| Schlagworte: | Anti-phospho-PLK, Anti-phospho-PLK1, Anti-phospho-PLK-1, Anti-phospho-STPK13, Anti-phospho-Polo-like kinase 1,... |
| Anwendung: | WB, IF, ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €
Anti-phospho-Plk (Thr210)
Artikelnummer: ELK-ES6619.100
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis, hence, it is a target...
| Schlagworte: | Anti-phospho-PLK, Anti-phospho-PLK1, Anti-phospho-PLK-1, Anti-phospho-STPK13, Anti-phospho-Polo-like kinase 1,... |
| Anwendung: | WB, IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €
Anti-Plk
Artikelnummer: ELK-ES6620.100
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis, hence, it is a target...
| Schlagworte: | Anti-PLK, Anti-PLK1, Anti-PLK-1, Anti-STPK13, Anti-Polo-like kinase 1, Anti-Serine/threonine-protein kinase 13,... |
| Anwendung: | WB, IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €
HMN-176
Artikelnummer: Cay37424-10
HMN-176 is an anticancer agent and active metabolite of the prodrug HMN-214 (Cay-26210). It is cytotoxic against a panel of cancer cell lines with a mean IC50 value of 112 nM, as well as P388 leukemia cells that are resistant to the DNA-crosslinking agent cisplatin (Cay-13119), anthracycline antitumor antibiotic...
| Schlagworte: | 4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-benzenesulfonamide |
| Anwendung: | Anticancer agent, active HMN-214 metabolite |
| CAS | 173529-10-7 |
| MW: | 382.4 D |
ab 122,00 €
Poloppin
Artikelnummer: Cay38330-1
Poloppin is an inhibitor of the protein-peptide interaction between polo-like kinase 1 (Plk1) and the Plk1-binding phosphopeptide (IC50 = 26.9 µM). It induces mitotic arrest in HeLa cells (EC50 = 29.9 µM). Poloppin inhibits cell growth in murine pancreatic organoids expressing mutant K-Ras (GI50s = 22.92-28.39...
| Schlagworte: | Polo Protein-protein Interaction Inhibitor, 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-2-propanoic acid |
| Anwendung: | Plk1-Plk1-binding phosphopeptide protein-peptide interaction inhibitor |
| CAS | 683808-78-8 |
| MW: | 438.2 D |
ab 35,00 €
BI-2536
Artikelnummer: Cay17385-1
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. BI-2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM). It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI-2536 induces mitotic arrest and apoptosis in diverse human cancer...
| Schlagworte: | 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-... |
| Anwendung: | Plk1 inhibitor |
| CAS | 755038-02-9 |
| MW: | 521.7 D |
ab 50,00 €
BI-6727
Artikelnummer: Cay18193-1
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. BI-6727 is a dihydropteridinone that inhibits Plk1, Plk2, and Plk3 (IC50s = 0.87, 5, and 56 nM, respectively), inducing mitotic arrest and apoptosis. It inhibits proliferation of multiple cancer cell lines with EC50 values ranging...
| Schlagworte: | Volasertib,... |
| Anwendung: | PLK1/2/3 inhibitor |
| CAS | 755038-65-4 |
| MW: | 618.8 D |
ab 50,00 €
GSK461364
Artikelnummer: Cay18099-1
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. GSK461364 is a potent, reversible inhibitor of Plk1 (Ki = 2.2 nM). It is less effective against Plk2 and Plk3 (Kis = 860 and 1,000 nM, respectively) and at least 1,000-fold selective for Plk1 over a panel of 48 other kinases....
| Schlagworte: | GSK461364A,... |
| Anwendung: | Plk1 inhibitor |
| CAS | 929095-18-1 |
| MW: | 543.6 D |
ab 46,00 €
Anti-PLK1
Artikelnummer: A300-251A
Protein function: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C)...
| Schlagworte: | Anti-PLK, Anti-PLK1, Anti-PLK-1, Anti-STPK13, EC=2.7.11.21, Anti-Polo-like kinase 1, Anti-Serine/threonine-protein kinase... |
| Anwendung: | WB, IP, ICC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
PLK1, active human recombinant protein
Artikelnummer: BPS-40033
Active human Plk1 (GenBank Accession No. NM_005030), full length with C-terminal HIS6 tag, MW=68 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PLK, PLK1, PLK-1, STPK13, Polo-like kinase 1, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 68 kD |
525,00 €
(R)-BI-2536
Artikelnummer: SYN-1019-M001
Soluble in DMSO, Ethanol. Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in...
| Schlagworte: | (R)-BI2536 |
| Anwendung: | PLK1 inhibitor |
| CAS | 755038-02-9 |
| MW: | 521,7 D |
ab 106,00 €