Zu "K06230" wurden 25 Artikel gefunden!
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GANT 61
Artikelnummer: Cay13841-10
Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers,...
| Schlagworte: | NSC 136476, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis(N,N-dimethyl-benzenamine) |
| Anwendung: | GLI antagonist |
| CAS | 500579-04-4 |
| MW: | 429.6 D |
ab 91,00 €
Gli Reporter - NIH3T3 Cell line (Hedgehog Pathway)
Artikelnummer: BPS-60409
The Gli Reporter - NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cell growth in embryonic and adult tissues and promotes tumor growth in a number of human cancers. The mammalian hedgehog proteins, Sonic Hedgehog (Shh), Indian Hedgehog...
| Schlagworte: | Gli cell line, Hedgehog reporter, |
| Anwendung: | Hedgehog pathway activity monitoring |
3.795,00 €
GANT61
Artikelnummer: AG-CR1-3561-M005
Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Hedgehog (Hh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays antiproliferative and antitumor activity in vitro and in vivo. Apoptosis inducer.
| Schlagworte: | NSC 136476, 2,2'-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine |
| Anwendung: | GLI antagonist |
| CAS | 500579-04-4 |
| MW: | 429,6 D |
ab 44,00 €
Anti-Gli-3
Artikelnummer: 600-401-694
Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated...
| Schlagworte: | Anti-GLI3 |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
733,00 €
Anti-Gli-2
Artikelnummer: 600-401-695
Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element. Implicated in the transduction of SHH signal.
| Schlagworte: | Anti-Gli2, Anti-Gli2 protein |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
733,00 €
Anti-Gli3
Artikelnummer: NSJ-R30859
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Gli-kruppel family member 3 is a member of the zinc finger family related to Kruppel, a protein family that is known to regulate development in Drosophila. The gene is expressed as an 8.5-kb mRNA in tissues such as testis, myometrium, placenta, and lung, and the...
| Schlagworte: | Anti-GLI3, Gli3 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-GLI3
Artikelnummer: ATA-HPA005534.100
Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated...
| Schlagworte: | Anti-GLI3 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
GANT 61
Artikelnummer: TGM-T3070-100mg
Description: GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2. Target: Autophagy, Hedgehog/Smoothened. Smiles: CN(C)c1ccccc1CN1CCCN(Cc2ccccc2N(C)C)C1c1ccncc1. References: Lauth M, et al. Proc Natl Acad Sci, 2007, 104(20), 8455-8560
| Schlagworte: | NSC 136476, GANT61 |
| Anwendung: | GLI antagonist |
| CAS | 500579-04-4 |
| MW: | 429.6 D |
ab 32,00 €
![Anti-GLI3 [R07-1F8] Monoclonal Antibody](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "Anti-GLI3 [R07-1F8] Monoclonal Antibody")
Anti-GLI3 [R07-1F8] Monoclonal Antibody
Artikelnummer: G-AGMB03071.100
GLI3 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and...
| Schlagworte: | Anti-GLI3, Anti-GLI3 form of 190 kDa, Anti-GLI3 full-length protein, Anti-Transcriptional activator GLI3 |
| Anwendung: | WB, ICC/IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 134,00 €
GLI, Human, Real Time PCR Primer Set
Artikelnummer: VHPS-3653
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | GLI, GLI1, Oncogene GLI, Zinc finger protein GLI1, Glioma-associated oncogene |
| Anwendung: | RNA quantification |
45,00 €
Anti-GLi3 (GLI-Kruppel Family Member GLI3)
Artikelnummer: G2035-54.100
Human GLI-3 is a 190kD transcription factor of the C2H2-type zinc-finger protein family. GLI-3 appears to play a role in limb and brain development, probably through sonic hedgehog signaling. GLI-3 is regulated by PKA-mediated phosphorylation. Unphosphorylated full-length GLI-3 is a transcriptional activator, while...
| Schlagworte: | Anti-GLI3FL, Anti-GLI3-83, Anti-GLI3-190, Anti-GLI3 form of 83 kDa, Anti-GLI3 form of 190 kDa, Anti-GLI3 full length... |
| Anwendung: | ELISA, ICC, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
1.071,00 €
GLI3 PrEST Antigen
Artikelnummer: ATA-APrEST77454.100
Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated...
| Schlagworte: | GLI3 |
| Anwendung: | Control antigen |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
264,00 €