Zu "K06230" wurden 19 Artikel gefunden!
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GANT 61
Artikelnummer: Cay13841-10
Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers,...
| Schlagworte: | NSC 136476, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis(N,N-dimethyl-benzenamine) |
| Anwendung: | GLI antagonist |
| CAS | 500579-04-4 |
| MW: | 429.6 D |
ab 109,00 €
Gli Reporter - NIH3T3 Cell line (Hedgehog Pathway)
Artikelnummer: BPS-60409
The Gli Reporter - NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cell growth in embryonic and adult tissues and promotes tumor growth in a number of human cancers. The mammalian hedgehog proteins, Sonic Hedgehog (Shh), Indian Hedgehog...
| Schlagworte: | Gli cell line, Hedgehog reporter, |
| Anwendung: | Hedgehog pathway activity monitoring |
3.471,00 €
GANT61
Artikelnummer: AG-CR1-3561-M005
Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Hedgehog (Hh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays antiproliferative and antitumor activity in vitro and in vivo. Apoptosis inducer.
| Schlagworte: | NSC 136476, 2,2'-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine |
| Anwendung: | GLI antagonist |
| CAS | 500579-04-4 |
| MW: | 429,6 D |
ab 50,00 €
Anti-Gli-3
Artikelnummer: 600-401-694
Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated...
| Schlagworte: | Anti-GLI3 |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
684,00 €
Anti-Gli-2
Artikelnummer: 600-401-695
Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element. Implicated in the transduction of SHH signal.
| Schlagworte: | Anti-Gli2, Anti-Gli2 protein |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
684,00 €
Anti-Gli3
Artikelnummer: NSJ-R30859
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Gli-kruppel family member 3 is a member of the zinc finger family related to Kruppel, a protein family that is known to regulate development in Drosophila. The gene is expressed as an 8.5-kb mRNA in tissues such as testis, myometrium, placenta, and lung, and the...
| Schlagworte: | Anti-GLI3, Gli3 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-GLI3
Artikelnummer: G-CAB15613.100
WB 1:500 - 1:2000. Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its...
| Schlagworte: | Anti-GLI3, GLI3 Polyclonal Antibody (CAB15613) |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 352,00 €
Anti-GLI3
Artikelnummer: ATA-HPA005534.100
Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated...
| Schlagworte: | Anti-GLI3 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 300,00 €
Anti-Gli3
Artikelnummer: G-CAB3300.100
Protein function: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated...
| Schlagworte: | Anti-GLI3, Gli3 Rabbit mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
ab 352,00 €
Anti-GLI3
Artikelnummer: E-AB-91222.120
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila...
| Schlagworte: | GLI3, GLI3 Polyclonal Antibody |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 198,00 €
Anti-GLI-3
Artikelnummer: ELK-ES5561.100
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila...
| Schlagworte: | Anti-GLI3, GLI-3 rabbit pAb |
| Anwendung: | IHC, IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €
GLI, Human, Real Time PCR Primer Set
Artikelnummer: VHPS-3653
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | GLI, GLI1, Oncogene GLI, Zinc finger protein GLI1, Glioma-associated oncogene |
| Anwendung: | RNA quantification |
43,00 €