Zu "K06170" wurden 46 Artikel gefunden!
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MK-0752
Artikelnummer: Cay16706-1
gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of gamma-secretase, reducing the cleavage of APP to Abeta40 in human neuroblastoma...
| Schlagworte: | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-cyclohexanepropanoic acid |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 471905-41-6 |
| MW: | 442.9 D |
ab 102,00 €
L-685,458
Artikelnummer: Cay14926-1
L-685,458 is an inhibitor of gamma-secretase (IC50 = 17 nM). It is selective for gamma-secretase over HIV-1, cathepsin D, trypsin, HepC3 NS3, papain, and calpain I proteases (IC50s = >1,000 nM). L-685,458 inhibits production of amyloid-beta (1-40) (Abeta40, Cay-21617) and Abeta42 (Cay-20574) in Neuro2A cells...
| Schlagworte: | gamma-Secretase Inhibitor X,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 292632-98-5 |
| MW: | 672.9 D |
ab 147,00 €
Avagacestat
Artikelnummer: Cay16711-1
gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. Avagacestat is a potent, orally bioavailable inhibitor of gamma-secretase that more potently inhibits the cleavage of APP to...
| Schlagworte: | BMS 708163,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 1146699-66-2 |
| MW: | 520.9 D |
ab 67,00 €
Semagacestat
Artikelnummer: Cay16713-5
Semagacestat is a potent inhibitor of gamma-secretase that blocks the production of Abeta38, Abeta40, and Abeta42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates gamma-secretase activity in vivo, altering Abeta levels in brain,...
| Schlagworte: | LY450139,... |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 425386-60-3 |
| MW: | 361.4 D |
ab 56,00 €
Anti-PEN2
Artikelnummer: 600-401-DL1
Anti-PEN2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PEN2 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...
| Schlagworte: | Anti-PEN2, Anti-PSENEN, Anti-MDS033, Anti-Gamma-secretase subunit PEN-2, Anti-Presenilin enhancer protein 2 |
| Anwendung: | ELISA, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
Anti-PEN2
Artikelnummer: 600-401-DL2
Anti-PEN2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PEN2 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...
| Schlagworte: | Anti-PEN2, Anti-PSENEN, Anti-MDS033, Anti-Gamma-secretase subunit PEN-2, Anti-Presenilin enhancer protein 2 |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
MK-0752
Artikelnummer: LKT-M4200.1
gamma-Secretase inhibitor.
| Anwendung: | gamma-Secretase inhibitor |
| CAS | 471905-41-6 |
| MW: | 442.9 D |
ab 109,00 €
MRK-560
Artikelnummer: Cay27599-1
MRK-560 is a potent inhibitor of gamma-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-beta (1-40) (Abeta40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Abeta40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also...
| Schlagworte: | N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide |
| Anwendung: | Potent gamma-secretase inhibitor |
| CAS | 677772-84-8 |
| MW: | 517.9 D |
ab 158,00 €
CHF5074
Artikelnummer: Cay27917-1
CHF5074 is a modulator of gamma-secretase and a derivative of flurbiprofen (Cay-70250). It inhibits the secretion of amyloid beta (1-42) (Abeta42) in H4-APP695NL human neuroglioma cells that overexpress a mutated form of amyloid precursor protein (APP, IC50 = 41 µM) and selectively inhibits secretion of Abeta42 over...
| Schlagworte: | CS 1103, CSP1103, Itanapraced, 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid |
| Anwendung: | gamma-secretase modulator |
| CAS | 749269-83-8 |
| MW: | 325.2 D |
ab 56,00 €
Begacestat
Artikelnummer: Cay27916-1
Begacestat is an inhibitor of gamma-secretase that inhibits cleavage of amyloid precursor protein (APP) to amyloid-beta (1-40) (Abeta40, Cay-21617) in vitro (IC50 = 15 nM). It is 14-fold selective for gamma-secretase over Notch-1. Begacestat (5 mg/kg) reduces brain levels of Abeta40 and Abeta42 (Cay-20574) in the...
| Schlagworte: | GSI-953, 5-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide |
| Anwendung: | gamma-secretase inhibitor |
| CAS | 769169-27-9 |
| MW: | 391.7 D |
ab 84,00 €
E2012
Artikelnummer: Cay29710-10
E2012 is a modulator of gamma-secretase. It selectively inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta) over Notch cleavage to its signaling effector Notch intracellular domain (NICD), processes both mediated by gamma-secretase, when used at a concentration of 1 µM in luciferase...
| Schlagworte: | (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidinone |
| Anwendung: | gamma-secretase modulator |
| CAS | 870843-42-8 |
| MW: | 419.5 D |
ab 145,00 €
NGP-555
Artikelnummer: Cay27918-1
NGP-555 is a modulator of gamma-secretase that inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta, IC50s = 531 and 131 nM for Abeta40 and Abeta42, respectively, in HeLa cell membranes). It is selective for AICD cleavage to Abeta over E-cadherin and Notch cleavage to their signaling...
| Schlagworte: | N-(5-ethyl-2,4-dimethylphenyl)-4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-thiazolamine |
| Anwendung: | gamma-secretase modulator |
| CAS | 1304630-27-0 |
| MW: | 406.5 D |
ab 174,00 €