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Zu "K05955" wurden 29 Artikel gefunden!
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Artikelnummer: ELK-ELK4902.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FNTa. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FNTa. Next,...
Schlagworte: | FNTA, FTase-alpha, GGTase-I-alpha, CAAX farnesyltransferase subunit alpha, Ras proteins prenyltransferase subunit alpha,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay37694-1
FGTI-2734 is a C-terminal mimetic of Ras and a dual inhibitor of farnesyltransferase (FTase) and geranylgeranyl transferase type I (GGTase I, IC50s = 250 and 520 nM, respectively). It inhibits prenylation of H-Ras and Rap1A in oncogenic H-Ras-transformed NIH3T3 cells (IC50s = 88.7 and 2,700 nM, respectively)....
Schlagworte: | N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)-2-pyridinesulfonamide |
Anwendung: | Ftase/GGTase I dual inhibitor |
CAS | 1247018-19-4 |
MW: | 510.6 D |
ab 35,00 €
Artikelnummer: Cay11433-1
Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi with diverse biological activities. It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 µM), blocking the degradation of IkappaBalpha and preventing the activation of NF-kappaB. Gliotoxin induces...
Schlagworte: | Aspergillin, 2,3R,5aS,6S-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10aR-epidithiopyrazino[1,2-a]indole-1,4-dione |
Anwendung: | Immunosuppressive mycotoxin |
CAS | 67-99-2 |
MW: | 326.4 D |
ab 77,00 €
Artikelnummer: Cay16176-1
Post-translational protein prenylation, a process catalyzed by three different enzymes, occurs at the C-terminal of a number of proteins involved in cell growth control and oncogenesis. One of these enzymes, geranylgeranyltransferase I (GGTase I) modifies cysteines of proteins with CAAX terminal sequences,...
Schlagworte: | N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, methyl ester, 2,2,2-trifluoroacetate |
Anwendung: | GGTase I inhibitor |
CAS | 1217457-86-7 |
MW: | 593.7 D |
ab 142,00 €
Artikelnummer: Cay11747-5
Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM). It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.Formal Name:...
Schlagworte: | R 115777, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone |
Anwendung: | CAAX-competitive farnesyltransferase inhibitor, Ras GTPase farnesylation inhibitor |
CAS | 192185-72-1 |
MW: | 489.4 D |
ab 60,00 €
Artikelnummer: Cay9003827-250
Gliotoxin-13C13 is intended for use as an internal standard for the quantification of gliotoxin (Cay-11433) by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi with diverse biological activities. It inhibits 20S proteasomal chymotrypsin activity...
Schlagworte: | Aspergillin-13C13,... |
Anwendung: | GC-MS, LC-MS internal standard, quantification, immunosuppressive mycotoxin |
MW: | 339.3 D |
811,00 €
Artikelnummer: Cay22940-5
L-778,123 is a dual inhibitor of farnesyl transferase (FTase, IC50 = 2 nM) and geranylgeranyl transferase type I (GGTase I, IC50 = 98 nM). It inhibits prenylation of the FTase and GGTase I substrates HDJ2 and RAP1A in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively). L-778,123 (1-300 µM) also...
Schlagworte: | 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-benzonitrile, monohydrochloride |
Anwendung: | Protein farnesyltransferase / geranylgeranyltransferase type-I inhibitor |
CAS | 253863-00-2 |
MW: | 442.3 D |
ab 130,00 €
Artikelnummer: A304-267A
Protein function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the...
Schlagworte: | Anti-FNTA, Anti-FTase-alpha, Anti-GGTase-I-alpha, Anti-CAAX farnesyltransferase subunit alpha, Anti-Ras proteins... |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay16607-5
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...
Schlagworte: | Farnesyltransferase Inhibitor II, FTI-II, N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
Anwendung: | Farnesyltransferase inhibitor |
MW: | 371.5 D |
ab 66,00 €
Artikelnummer: Cay22755-500
FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase, IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase, IC50 = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of...
Schlagworte: | Farnesyltransferase Inhibitor I, N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl-L-methionine |
Anwendung: | Potent farnesyltransferase inhibitor |
CAS | 149759-96-6 |
MW: | 470.7 D |
ab 98,00 €
Artikelnummer: ARG58734.100
Protein function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the...
Schlagworte: | Anti-FNTA, Anti-FTase-alpha, Anti-GGTase-I-alpha, Anti-CAAX farnesyltransferase subunit alpha, Anti-Ras proteins... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
624,00 €
Artikelnummer: ARG58752.100
Protein function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the...
Schlagworte: | Anti-FNTA, Anti-FTase-alpha, Anti-GGTase-I-alpha, Anti-CAAX farnesyltransferase subunit alpha, Anti-Ras proteins... |
Anwendung: | IHC (paraffin) |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
584,00 €