Zu "K05954" wurden 41 Artikel gefunden!
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FPT Inhibitor I
Artikelnummer: Cay45256-1
A FTase inhibitor (IC50 = 0.083 µM), is selective for FTase over GGTase I, GGTase II, SQS, and MK (IC50s = 26, 47, 516, and >200 µM, respectively), decreases FTase-mediated farnesylation of H-Ras in a cell-free assay. SMILES: C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CNC(C(C([O-])=O)CP([O-])([O-])=O)=O.[Na+].[Na+].[Na+]. InChi...
| Schlagworte: | (E,E)-3-oxo-2-(phosphonomethyl)-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)amino]-propanoic acid, trisodium salt |
| Anwendung: | FTase inhibitor |
| CAS | 162934-54-5 |
| MW: | 467.4 D |
ab 73,00 €
FTI-277 (hydrochloride)
Artikelnummer: Cay10011667-10
An FTase inhibitor (IC50 = 0.1 µM), selective for FTase over GGTase (IC50 = >10 µM), inhibits IL-1beta-induced production of NO in primary rat pulmonary artery smooth muscle cells at 10 µM, decreases the proliferation of A549 cells when used at 10 µM and induces cell cycle arrest at the G2/M phase in the same cells...
| Schlagworte: | Farnesyltransferase Inhibitor 277, FTase Inhibitor 277,... |
| Anwendung: | Farnesyltransferase inhibitor |
| CAS | 261636-47-9 |
| MW: | 447.61 D |
ab 186,00 €
Manumycin A
Artikelnummer: Cay10010497-1
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...
| Schlagworte: | NSC 622141, UCF 1C,... |
| Anwendung: | FTase inhibitor |
| CAS | 52665-74-4 |
| MW: | 550.7 D |
ab 166,00 €
Lonafarnib
Artikelnummer: Cay11746-1
Farnesyltransferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyltransferase...
| Schlagworte: | Sarasar, SCH 66336,... |
| Anwendung: | Farnesyl transferase inhibitor |
| CAS | 193275-84-2 |
| MW: | 638.8 D |
ab 50,00 €
Arglabin
Artikelnummer: AG-CN2-0458-M001
White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
| Schlagworte: | Arglabine |
| Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
| CAS | 84692-91-1 |
| MW: | 246,3 D |
ab 77,00 €
LB 42708
Artikelnummer: Cay16428-5
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...
| Schlagworte: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
| Anwendung: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.5 D |
ab 67,00 €
FTase Inhibitor II (trifluoroacetate salt)
Artikelnummer: Cay16607-1
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...
| Schlagworte: | Farnesyltransferase Inhibitor II, FTI-II, N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
| Anwendung: | Farnesyltransferase inhibitor |
| MW: | 371.5 D |
ab 73,00 €
Arglabin
Artikelnummer: Cay19502-1
Arglabin is a sesquiterpene gamma-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities. It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively). Arglabin reduces tumor growth in an SCC-4 mouse...
| Schlagworte: | (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one |
| Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
| CAS | 84692-91-1 |
| MW: | 246.3 D |
ab 57,00 €
Andrastin A
Artikelnummer: AG-CN2-0144-C250
Isolated from Aspergillus fumigatus. Mycotoxin. Protein farnesyltransferase (PFTase) inhibitor. Anti-cancer compound. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.
| Anwendung: | Protein farnesyltransferase inhibitor |
| CAS | 174232-42-9 |
| MW: | 486,6 D |
ab 77,00 €
Anti-FNTB
Artikelnummer: A305-407A
Protein function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. [The UniProt Consortium]
| Schlagworte: | Anti-FNTB, Anti-FTase-beta, EC=2.5.1.58, Anti-CAAX farnesyltransferase subunit beta, Anti-Protein farnesyltransferase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Andrastin A
Artikelnummer: Cay22067-500
Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Cay-11764 in multidrug resistant VJ-300 cell culture (the IC50 of vincristine decreased 1.5-20-fold upon treatment with 6.25 µg/ml to 50 µg/ml of of andrastin A),...
| Schlagworte: | NSC 697452,... |
| Anwendung: | Farnesyltransferase inhibitor |
| CAS | 174232-42-9 |
| MW: | 486.6 D |
300,00 €
Palmarumycin C3
Artikelnummer: BVT-0078-M001
Rasfarnesyltransferase inhibitor, Antifungal, antibacterial and herbicidal, Structurally unique natural products, The basic structure of palmarumycin C1 can be modified by a number of hydroxylation, oxygenation, dehydrogenation and chlorination steps. Isolated from Sphaeropsidales sp.
| Schlagworte: | (1a'R,7a'S)-3',6'-Dihydroxy-1a'H-spiro[naphtho[1,8-de][1,3]dioxine-2,2'-naphtho[2,3-b]oxiren]-7'(7a'H)-one |
| Anwendung: | Ras farnesyltransferase inhibitor |
| CAS | 159934-11-9 |
| MW: | 348,3 D |
ab 145,00 €