Zu "K05954" wurden 43 Artikel gefunden!
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FPT Inhibitor I
Artikelnummer: Cay45256-1
A FTase inhibitor (IC50 = 0.083 µM), is selective for FTase over GGTase I, GGTase II, SQS, and MK (IC50s = 26, 47, 516, and >200 µM, respectively), decreases FTase-mediated farnesylation of H-Ras in a cell-free assay. SMILES: C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CNC(C(C([O-])=O)CP([O-])([O-])=O)=O.[Na+].[Na+].[Na+]. InChi...
| Schlagworte: | (E,E)-3-oxo-2-(phosphonomethyl)-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)amino]-propanoic acid, trisodium salt |
| Anwendung: | FTase inhibitor |
| CAS | 162934-54-5 |
| MW: | 467.4 D |
ab 76,00 €
Manumycin A
Artikelnummer: Cay10010497-1
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...
| Schlagworte: | NSC 622141, UCF 1C,... |
| Anwendung: | FTase inhibitor |
| CAS | 52665-74-4 |
| MW: | 550.7 D |
ab 172,00 €
Lonafarnib
Artikelnummer: Cay11746-1
Farnesyltransferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyltransferase...
| Schlagworte: | Sarasar, SCH 66336,... |
| Anwendung: | Farnesyl transferase inhibitor |
| CAS | 193275-84-2 |
| MW: | 638.8 D |
ab 53,00 €
Arglabin
Artikelnummer: AG-CN2-0458-M001
White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
| Schlagworte: | Arglabine |
| Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
| CAS | 84692-91-1 |
| MW: | 246,3 D |
ab 77,00 €
LB 42708
Artikelnummer: Cay16428-5
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...
| Schlagworte: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
| Anwendung: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.5 D |
ab 69,00 €
FTase Inhibitor II (trifluoroacetate salt)
Artikelnummer: Cay16607-1
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...
| Schlagworte: | Farnesyltransferase Inhibitor II, FTI-II, N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
| Anwendung: | Farnesyltransferase inhibitor |
| MW: | 371.5 D |
ab 76,00 €
Arglabin
Artikelnummer: Cay19502-1
Arglabin is a sesquiterpene gamma-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities. It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively). Arglabin reduces tumor growth in an SCC-4 mouse...
| Schlagworte: | (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one |
| Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
| CAS | 84692-91-1 |
| MW: | 246.3 D |
ab 59,00 €
Andrastin A
Artikelnummer: AG-CN2-0144-C250
Isolated from Aspergillus fumigatus. Mycotoxin. Protein farnesyltransferase (PFTase) inhibitor. Anti-cancer compound. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.
| Anwendung: | Protein farnesyltransferase inhibitor |
| CAS | 174232-42-9 |
| MW: | 486,6 D |
ab 77,00 €
Anti-FNTB
Artikelnummer: A305-407A
Protein function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. [The UniProt Consortium]
| Schlagworte: | Anti-FNTB, Anti-FTase-beta, EC=2.5.1.58, Anti-CAAX farnesyltransferase subunit beta, Anti-Protein farnesyltransferase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Andrastin A
Artikelnummer: Cay22067-500
Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Cay-11764 in multidrug resistant VJ-300 cell culture (the IC50 of vincristine decreased 1.5-20-fold upon treatment with 6.25 µg/ml to 50 µg/ml of of andrastin A),...
| Schlagworte: | NSC 697452,... |
| Anwendung: | Farnesyltransferase inhibitor |
| CAS | 174232-42-9 |
| MW: | 486.6 D |
309,00 €
Palmarumycin C3
Artikelnummer: BVT-0078-M001
Rasfarnesyltransferase inhibitor, Antifungal, antibacterial and herbicidal, Structurally unique natural products, The basic structure of palmarumycin C1 can be modified by a number of hydroxylation, oxygenation, dehydrogenation and chlorination steps. Isolated from Sphaeropsidales sp.
| Schlagworte: | (1a'R,7a'S)-3',6'-Dihydroxy-1a'H-spiro[naphtho[1,8-de][1,3]dioxine-2,2'-naphtho[2,3-b]oxiren]-7'(7a'H)-one |
| Anwendung: | Ras farnesyltransferase inhibitor |
| CAS | 159934-11-9 |
| MW: | 348,3 D |
ab 145,00 €
Manumycin B
Artikelnummer: BVT-0264-M001
Isolated from Streptomyces parvulus. Antibiotic. Antibacterial. Active against Gram-positive bacteria. Rasfarnesyltransferase inhibitor. Apoptosis (Caspase-1) inhibitor. AChE inhibitor.
| Schlagworte: | UCF1A, N98-1272A |
| Anwendung: | Rasfarnesyltransferase inhibitor, AChE inhibitor |
| CAS | 139023-58-8 |
| MW: | 510,6 D |
105,00 €