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Zu "K05954" wurden 33 Artikel gefunden!
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Artikelnummer: ELK-ELK5384.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FNTb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FNTb. Next,...
Schlagworte: | FNTB, FTase-beta, EC=2.5.1.58, CAAX farnesyltransferase subunit beta, Protein farnesyltransferase subunit beta, Ras... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: BVT-0091-M001
Antibiotic, Potent, selective and competitive cell-permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM), Does not affect geranylgeranyltransferase (IC50 = 180 µM), Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras, Neutral sphingomyelinase inhibitor, Blocks...
Anwendung: | Rasfarnesyltransferase inhibitor |
CAS | 52665-74-4 |
MW: | 550,6 D |
ab 100,00 €
Artikelnummer: Cay10010497-1
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...
Schlagworte: | NSC 622141, UCF 1C,... |
Anwendung: | FTase inhibitor |
CAS | 52665-74-4 |
MW: | 550.7 D |
ab 149,00 €
Artikelnummer: Cay11746-1
Farnesyltransferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyltransferase...
Schlagworte: | Sarasar, SCH 66336,... |
Anwendung: | Farnesyl transferase inhibitor |
CAS | 193275-84-2 |
MW: | 638.8 D |
ab 44,00 €
Artikelnummer: Cay10011661-1
FTI-276 is a CAAX peptidomimetic inhibitor of farnesyltransferase (FTase, IC50 = 500 pM). It contains the C-terminal CAAX sequence, Cys-Val-Iso-Met (CVIM), of K-Ras4B, a form of Ras that is commonly mutated in human cancers, and is selective for FTase over geranylgeranyltransferase I (GGTase I, IC50 = 50 nM). It...
Schlagworte: | Farnesyltransferase Inhibitor 276,... |
Anwendung: | Peptidomimetic FTase inhibitor |
CAS | 1217471-51-6 |
MW: | 547.6 D |
ab 135,00 €
Artikelnummer: AG-CN2-0458-M001
White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
Schlagworte: | Arglabine |
Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
CAS | 84692-91-1 |
MW: | 246,3 D |
ab 83,00 €
Artikelnummer: Cay16428-5
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...
Schlagworte: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
Anwendung: | FTase inhibitor |
CAS | 226929-39-1 |
MW: | 555.5 D |
ab 60,00 €
Artikelnummer: Cay16607-1
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...
Schlagworte: | Farnesyltransferase Inhibitor II, FTI-II, N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
Anwendung: | Farnesyltransferase inhibitor |
MW: | 371.5 D |
ab 66,00 €
Artikelnummer: Cay19502-1
Arglabin is a sesquiterpene gamma-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities. It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively). Arglabin reduces tumor growth in an SCC-4 mouse...
Schlagworte: | (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one |
Anwendung: | Anticancer compound, Farnesyltransferase inhibitor |
CAS | 84692-91-1 |
MW: | 246.3 D |
ab 66,00 €
Artikelnummer: AG-CN2-0144-C250
Isolated from Aspergillus fumigatus. Mycotoxin. Protein farnesyltransferase (PFTase) inhibitor. Anti-cancer compound. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.
Anwendung: | Protein farnesyltransferase inhibitor |
CAS | 174232-42-9 |
MW: | 486,6 D |
ab 99,00 €
Artikelnummer: A305-407A
Protein function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. [The UniProt Consortium]
Schlagworte: | Anti-FNTB, Anti-FTase-beta, EC=2.5.1.58, Anti-CAAX farnesyltransferase subunit beta, Anti-Protein farnesyltransferase... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay22067-500
Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Cay-11764 in multidrug resistant VJ-300 cell culture (the IC50 of vincristine decreased 1.5-20-fold upon treatment with 6.25 µg/ml to 50 µg/ml of of andrastin A),...
Schlagworte: | NSC 697452,... |
Anwendung: | Farnesyltransferase inhibitor |
CAS | 174232-42-9 |
MW: | 486.6 D |
270,00 €