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Zu "K05931" wurden 50 Artikel gefunden!
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Artikelnummer: A300-421A
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from...
Schlagworte: | Anti-CARM1, Anti-PRMT4, Anti-Protein arginine N-methyltransferase 4, Anti-Histone-arginine methyltransferase CARM1,... |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Artikelnummer: BPS-51047
Active human PRMT4 (CARM1) (GenBank Accession No. NM_199141), amino-acids 2-end, with N-terminal HIS tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: | CARM1, PRMT4, Protein arginine N-methyltransferase 4, Histone-arginine methyltransferase CARM1, Coactivator-associated... |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 66 kD |
664,00 €
Artikelnummer: Cay10569-100
Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark, and peels. It has anti-carcinogenic, anti-mutagenic, anti-inflammatory, and organ-preserving properties, presumably related to its ability to alter cytochrome P450 activity and improve metabolism and clearance of...
Schlagworte: | Gallogen, Lagistase, TBBD, 2,3,7,8-tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione |
Anwendung: | Antioxidant |
CAS | 476-66-4 |
MW: | 302.2 D |
ab 26,00 €
Artikelnummer: Cay29954-1
EZM2302 is an inhibitor of protein arginine methyltransferase 4 (PRMT4, IC50 = 6 nM). It decreases asymmetric methylation of the PRMT4 substrate PABP1 (IC50 = 0.038 µM) and increases levels of demethylated SmB (EC50 = 0.018 µM) in RPMI-8226 multiple myeloma cells. EZM2302 inhibits proliferation in a panel of 36...
Schlagworte: | GSK3359088,... |
Anwendung: | PRMT4 inhibitor |
CAS | 1628830-21-6 |
MW: | 585.1 D |
ab 92,00 €
Artikelnummer: ARG53996.100
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from...
Schlagworte: | Anti-CARM1, Anti-PRMT4, EC=2.1.1.-, EC=2.1.1.125, Anti-Protein arginine N-methyltransferase 4, Anti-Histone-arginine... |
Anwendung: | WB, IP |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse |
624,00 €
Artikelnummer: Cay18361-5
MS023 is an inhibitor of type I protein arginine methyltransferases (PRMTs, IC50s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively). It is selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 protein lysine methyltransferases (PKMTs) and DNA methyltransferases...
Schlagworte: | N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine, trihydrochloride |
Anwendung: | Potent, selective type I PRMT inhibitor |
CAS | 2108631-19-0 |
MW: | 396.8 D |
ab 77,00 €
Artikelnummer: IHC-00045
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from...
Schlagworte: | Anti-CARM1, Anti-PRMT4, Anti-Protein arginine N-methyltransferase 4, Anti-Histone-arginine methyltransferase CARM1,... |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay11033-1
PRMT4/CARM1 Inhibitor selectively blocks the activity of PRMT4/CARM1 with an IC50 value of 7.1 µM. It displays very low affinity towards PRMT1 and SET7 with IC50 values of 63 and 943 µM, respectively. In human prostate cancer LNCaP cells, this compound reduced the prostate-specific antigen promoter activity at 8-10...
Schlagworte: | Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor,... |
CAS | 1020399-49-8 |
MW: | 555.3 D |
ab 109,00 €
Artikelnummer: Cay18348-25
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases...
Schlagworte: | N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride |
Anwendung: | PRMT4 inhibitor, PRMT6 inhibitor |
CAS | 2095432-59-8 |
MW: | 321.3 D |
ab 60,00 €
Artikelnummer: ARG51803.100
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from...
Schlagworte: | Anti-phospho-PRMT4, Anti-phospho-CARM1, Anti-phospho-Protein arginine N-methyltransferase 4, Anti-phospho-Histone-arginine... |
Anwendung: | WB, ICC, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | rat |
ab 436,00 €
Artikelnummer: BPS-27219
Ellagic acid, also known as TBBD, Gallogen, and Lagistase, can alter cytochrome P450 activity, and improve metabolism and clearance of xenobiotics, as well as alter immune function. It can also block methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1), or...
Schlagworte: | Ellagic acid, TBBD, Gallogen, Lagistase, |
Anwendung: | PRMT4 inhibitor |
MW: | 302.2 D |
223,00 €
Artikelnummer: BPS-52068
The PRMT4 Homogeneous Assay Kit is designed to measure PRMT4 activity for screening and profiling applications. PRMT4 (CARM1) is an arginine methyltransferase and dual functional coregulator that facilitates transcription initiation by methylation of Arg17 and Arg26 of histone H3. The PRMT4 Homogeneous Assay Kit...
Schlagworte: | PRMT4, CARM1, Coactivator-Associated Arginine Methyltransferase 1, |
Anwendung: | Enzyme kinetics, HTS |
Spezies-Reaktivität: | human |
2.933,00 €