Zu "K05917" wurden 130 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
VT-1161
Artikelnummer: Cay43577-1
VT-1161 is an antifungal agent. It selectively binds to C. albicans lanosterol 14-alpha-demethylase (Kd = 39 nM), also known as cytochrome P450 (CYP) isoform CYP51, over human lanosterol 14-alpha-demethylase at 86 µM and does not inhibit human CYP2C9, CYP2C19, or CYP3A4 (IC50s = 99, 72, and 65 µM, respectively)....
| Schlagworte: | Oteseconazole,... |
| Anwendung: | Antifungal agent, ergosterol biosynthesis inhibitor |
| CAS | 1340593-59-0 |
| MW: | 527.4 D |
ab 101,00 €
Ketoconazole
Artikelnummer: Cay15212-100
Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml). It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol...
| Schlagworte: | R 41400,... |
| Anwendung: | Cytochrome P450 inhibitor |
| CAS | 65277-42-1 |
| MW: | 531.4 D |
ab 89,00 €
Difenoconazole-d6 (hydrochloride)
Artikelnummer: Cay27834-1
Difenoconazole-d6 is intended for use as an internal standard for the quantification of difenoconazole (Cay-24053) by GC- or LC-MS. Difenoconazole is a triazole fungicide. It is active against eight F. graminearum isolates (EC50s = 1.69-19.6 mg/L) and A. sonali, F. fulva, B. cinerea, and R. solani (EC50s = 0.131,...
| Schlagworte: | 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-(methyl-d3)-1,3-dioxolan-2-yl-4,5,5-d3)methyl)-1H-1,2,4-triazole,... |
| Anwendung: | GC-MS, LC-MS, internal standard, conazole fungicide |
| CAS | 2748435-81-4 |
| MW: | 448.8 D |
180,00 €
Ketoconazole
Artikelnummer: LKT-K1676.5
An inhibitor of cytochrome P-450 in steroid biosynthesis, and an inhibitor of lipoxygenase and thromboxane synthase activities. It is classified as antineoplastic, antimetastatic, and antipsoriatic.
| Anwendung: | Cytochrome P-450 inhibitor |
| CAS | 65277-42-1 |
| MW: | 531,44 D |
ab 200,00 €
Fluconazole
Artikelnummer: Cay11594-500
Fluconazole is a triazole antifungal agent that is effective against most Candida strains. In vivo fluconazole at 0.5-100 mg/kg demonstrates protective activity in various experimental animal models of systemic fungal diseases including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis,...
| Schlagworte: | UK 49858, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol |
| Anwendung: | Antifungal agent, CYP51 inhibitor |
| CAS | 86386-73-4 |
| MW: | 306.3 D |
ab 62,00 €
Posaconazole
Artikelnummer: Cay14737-10
Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14alpha-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the...
| Schlagworte: | POS, SCH 56592,... |
| Anwendung: | Antifungal, lanosterol 14a-demethylase inhibitor |
| CAS | 171228-49-2 |
| MW: | 700.8 D |
ab 95,00 €
Voriconazole-d3
Artikelnummer: Cay17803-1
Voriconazole-d3 is intended for use as an internal standard for the quantification of voriconazole (Cay-15633) by GC- or LC-MS. Voriconazole is a triazole antifungal agent and a derivative of fluconazole (Cay-11594). It is active against a variety of yeast and fungi, including clinical isolates of A. flavus, A....
| Schlagworte: | VRC-d3, (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-4,4,4-d3-2-ol |
| Anwendung: | Internal standard |
| MW: | 352.3 D |
ab 274,00 €
Fosravuconazole (L-lysine ethanolate)
Artikelnummer: Cay42133-1
A prodrug form of ravuconazole, increases survival in a mouse model of systemic C. albicans infection. Formulation: A solid. InChI:...
| Schlagworte: | BMS 379224, E1224, F-RVCZ, L-Lysine, compd. with... |
| Anwendung: | Ravuconazole prodrug form, antifungal, ergosterol biosynthesis inhibitor |
| CAS | 914361-45-8 |
| MW: | 739.7 D |
ab 40,00 €
Fluconazole-d4
Artikelnummer: Cay18252-500
Fluconazole-d4 is intended for use as an internal standard for the quantification of fluconazole (Cay-11594) by GC- or LC-MS. Fluconazole is a triazole antifungal agent that is effective against most Candida strains. In vivo, fluconazole at 0.5-100 mg/kg demonstrates protective activity in various experimental...
| Schlagworte: | alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl-d2)-1H-1,2,4-triazole-1-ethan-beta,beta-d2-ol |
| Anwendung: | MS, internal control, antifungal, sterol 14alpha-demethylase ihibitor |
| CAS | 1124197-58-5 |
| MW: | 310.3 D |
ab 144,00 €
Econazole (nitrate)
Artikelnummer: Cay20223-1
Econazole (nitrate) is an azole-based antifungal compound that acts by inhibiting the 14alpha-demethylation of lanosterol (Cay-19521), which consequently leads to the inhibition of ergosterol (Cay-19850) synthesis in fungal cell membranes. It demonstrates broad-spectrum activity against dermatophytes, Candida...
| Schlagworte: | NSC 243115, SQ 13,020, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, mononitrate |
| Anwendung: | Antifungal, ergosterol biosynthesis inhibitor |
| CAS | 24169-02-6 |
| MW: | 444.7 D |
ab 40,00 €
Miconazole (nitrate)
Artikelnummer: Cay15420-1
Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14alpha-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a...
| Schlagworte: | NSC 169434, R 14889, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole, mononitrate |
| Anwendung: | Sterol 14alpha-demethylase inhibitor, antifungal imidazole |
| CAS | 22832-87-7 |
| MW: | 479.1 D |
ab 53,00 €
Clotrimazole
Artikelnummer: Cay15278-50
Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-alpha demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells,...
| Schlagworte: | BAY-B-5087, NSC 257473, 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole |
| Anwendung: | Fungal sterol 14alpha-demethylase inhibitor |
| CAS | 23593-75-1 |
| MW: | 344.8 D |
ab 51,00 €