Zu "K05856" wurden 110 Artikel gefunden!
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Anti-Recombinant Lck, clone 3F5
Artikelnummer: E-AN300942L.100
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating...
| Schlagworte: | Anti-LCK, Anti-p56-LCK, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase Lck, Anti-Leukocyte... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
PP2
Artikelnummer: Cay13198-1
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible,...
| Schlagworte: | AGL 1879, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-27-9 |
| MW: | 301.8 D |
ab 49,00 €
PP1 (Src Inhibitor)
Artikelnummer: Cay14244-1
PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 µM),...
| Schlagworte: | AGL 1872, EI 275, 1-(1,1-dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-26-8 |
| MW: | 281.4 D |
ab 73,00 €
Emodin
Artikelnummer: TGM-T2869-50mg
Description: Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, exerts antiproliferative effects in Y cells that are regulated by different signaling pathways. Target: Autophagy, SARS-CoV, Casein Kinase. Smiles:...
| Schlagworte: | Frangula emodin |
| Anwendung: | p56lck protein kinase inhibitor |
| CAS | 518-82-1 |
| MW: | 270.24 D |
ab 43,00 €
Anti-phospho-Lck (Tyr394)
Artikelnummer: ARG51643.50
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-phospho-LCK, Anti-phospho-LSK, Anti-phospho-p56-LCK, EC=2.7.10.2, Anti-phospho-Protein YT16,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 471,00 €
Piceatannol
Artikelnummer: AG-CN2-0086-M005
Synthetic. Originally isolated from Euphorbia lagascae. Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB...
| Schlagworte: | CCRIS 9289, NSC365798, NSC622471, 3,3',4,5'-Tetrahydroxy-trans-stilbene, 3-Hydroxyresveratrol |
| Anwendung: | Tyrosine and serine/threonine protein kinase inhibitor |
| CAS | 10083-24-6 |
| MW: | 244,3 D |
ab 33,00 €
PD 173955
Artikelnummer: Cay30618-5
PD 173955 is a tyrosine kinase inhibitor. It inhibits c-Src, Yes, and LCK (IC50s = 25, 22, and 5 nM, respectively), as well as Bcr-Abl and c-Kit (IC50s = 1-2 and 25 nM, respectively), and is selective for these kinases over the insulin receptor (InsR), alpha-FGFR, basic FGFR (bFGFR), PDGFR, and PKC. PD 173955 (5,000...
| Schlagworte: | 6-(2,6-dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 260415-63-2 |
| MW: | 443.4 D |
ab 49,00 €
A-770041
Artikelnummer: Cay32854-1
A-770041 is an inhibitor of LCK kinase (IC50 = 0.147 µM). It is selective for LCK over other Src family tyrosine kinases including Src, Fyn, Fgr, HCK, and Tie2 (IC50s = 9.05, 44.1, 14.1, 1.22, and >50 µM, respectively). A-770041 induces dephosphorylation of LCK by SHP-1, inactivating LCK, in IgE/antigen-stimulated...
| Schlagworte: | N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1... |
| Anwendung: | LCK inhibitor |
| CAS | 869748-10-7 |
| MW: | 621.7 D |
ab 85,00 €
Anomalin A
Artikelnummer: AG-CN2-0006-M001
Lck (p56lck, lymphocyte specific tyrosine kinase) inhibitor, Antioxidant, DPPH radical scavenger. Isolated from marine fungus Arthrinium sp.
| Schlagworte: | 2,3,6,8-Tetrahydroxy-1-methylxanthone |
| Anwendung: | Lck inhibitor |
| CAS | 548740-86-9 |
| MW: | 274,1 D |
132,00 €
Anti-phospho-Lck (Tyr505)
Artikelnummer: ARG51824.100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-phospho-LCK, Anti-phospho-LSK, Anti-phospho-p56-LCK, EC=2.7.10.2, Anti-phospho-Protein YT16,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 471,00 €
Anti-LCK, clone 3E5-C8-B9
Artikelnummer: ARG54095.100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
658,00 €
Anti-Lck, clone LCK-01
Artikelnummer: ARG63058.100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase... |
| Anwendung: | FC, ICC, IF, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 460,00 €