Zu "K05856" wurden 103 Artikel gefunden!
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PP2
Artikelnummer: Cay13198-1
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible,...
| Schlagworte: | AGL 1879, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-27-9 |
| MW: | 301.8 D |
ab 43,00 €
PP1 (Src Inhibitor)
Artikelnummer: Cay14244-1
PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 µM),...
| Schlagworte: | AGL 1872, EI 275, 1-(1,1-dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-26-8 |
| MW: | 281.4 D |
ab 66,00 €
Anti-phospho-Lck (Tyr394)
Artikelnummer: ARG51643.50
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-phospho-LCK, Anti-phospho-LSK, Anti-phospho-p56-LCK, EC=2.7.10.2, Anti-phospho-Protein YT16,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 436,00 €
PD 173955
Artikelnummer: Cay30618-5
PD 173955 is a tyrosine kinase inhibitor. It inhibits c-Src, Yes, and LCK (IC50s = 25, 22, and 5 nM, respectively), as well as Bcr-Abl and c-Kit (IC50s = 1-2 and 25 nM, respectively), and is selective for these kinases over the insulin receptor (InsR), alpha-FGFR, basic FGFR (bFGFR), PDGFR, and PKC. PD 173955 (5,000...
| Schlagworte: | 6-(2,6-dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 260415-63-2 |
| MW: | 443.4 D |
ab 43,00 €
A-770041
Artikelnummer: Cay32854-5
A-770041 is an inhibitor of LCK kinase (IC50 = 0.147 µM). It is selective for LCK over other Src family tyrosine kinases including Src, Fyn, Fgr, HCK, and Tie2 (IC50s = 9.05, 44.1, 14.1, 1.22, and >50 µM, respectively). A-770041 induces dephosphorylation of LCK by SHP-1, inactivating LCK, in IgE/antigen-stimulated...
| Schlagworte: | N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1... |
| Anwendung: | LCK inhibitor |
| CAS | 869748-10-7 |
| MW: | 621.7 D |
ab 77,00 €
-15 %
Rabattaktion
Anti-Lck (Clone: ABM18H9)
Artikelnummer: ABE-10-8003-100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
149,00 €
ab 126,65 €
Anomalin A
Artikelnummer: AG-CN2-0006-M001
Lck (p56lck, lymphocyte specific tyrosine kinase) inhibitor, Antioxidant, DPPH radical scavenger. Isolated from marine fungus Arthrinium sp.
| Schlagworte: | 2,3,6,8-Tetrahydroxy-1-methylxanthone |
| Anwendung: | Lck inhibitor |
| CAS | 548740-86-9 |
| MW: | 274,1 D |
132,00 €
Anti-phospho-Lck (Tyr505)
Artikelnummer: ARG51824.100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-phospho-LCK, Anti-phospho-LSK, Anti-phospho-p56-LCK, EC=2.7.10.2, Anti-phospho-Protein YT16,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 436,00 €
Anti-LCK, clone 3E5-C8-B9
Artikelnummer: ARG54095.100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
624,00 €
Anti-Lck, clone LCK-01
Artikelnummer: ARG63058.100
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the...
| Schlagworte: | Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase... |
| Anwendung: | FC, ICC, IF, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 436,00 €
LCK, active human recombinant protein
Artikelnummer: BPS-40470
Active recombinant full-length human LCK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. The gene accession number is NM_005356.
| Schlagworte: | LCK, LSK, p56-LCK, EC=2.7.10.2, Protein YT16, Proto-oncogene Lck, Tyrosine-protein kinase Lck, Leukocyte C-terminal Src... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 84 kD |
540,00 €
Anti-LCK, clone 845CT3.5.2
Artikelnummer: NSJ-F53783-0.1ML
In ascites with 0.09% sodium azide. Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively...
| Schlagworte: | Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase... |
| Anwendung: | WB, ELISA |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
702,00 €