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Zu "K05658" wurden 135 Artikel gefunden!
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Artikelnummer: ARG67069.100
Protein function: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine,...
Schlagworte: | Anti-MDR1, Anti-CD243, Anti-CD243, Anti-P-glycoprotein 1, Anti-P-glycoprotein 1, Anti-Multidrug resistance protein 1,... |
Anwendung: | IHC (paraffin) |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
624,00 €
Artikelnummer: Cay16672-5
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp, also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp. As P-gp is expressed on a population of stem...
Schlagworte: | R-22420, R-302, RH123, 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-xanthylium, monochloride |
Anwendung: | Membrane-permeable cationic dye, P-glycoprotein substrate, Mitochondrial stain |
CAS | 62669-70-9 |
MW: | 380.8 D |
ab 43,00 €
Artikelnummer: A303-625A
Protein function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. [The UniProt Consortium]
Schlagworte: | Anti-MDR1, Anti-ABCB1, Anti-CD243, EC=3.6.3.44, Anti-P-glycoprotein 1, Anti-Multidrug resistance protein 1,... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay15421-5
Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities. It reduces LPS- and IFN-gamma-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM. Nobiletin...
Schlagworte: | NSC 618903, NSC 76751, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one |
Anwendung: | Natural polymethoxylated flavonoid |
CAS | 478-01-3 |
MW: | 402.4 D |
ab 48,00 €
Artikelnummer: Cay24180-100
Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine (Cay-11762) and paclitaxel (Cay-10461) in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug...
Schlagworte: | XR9576,... |
Anwendung: | P-Glycoprotein inhibitor |
CAS | 206873-63-4 |
MW: | 646.7 D |
ab 82,00 €
Artikelnummer: Cay21533-5
Zosuquidar is a modulator of P-glycoprotein (P-gp, Ki = 59 nM). It restores the sensitivity of P-gp-expressing cancer cells to vinblastine (Cay-11762), doxorubicin (Cay-15007), etoposide (Cay-12092), and paclitaxel (Cay-10461) when used at 0.1 µM. It less potently inhibits cytochrome P450 (CYP) isoforms CYP3A,...
Schlagworte: | LY335979, RS 33295-198,... |
Anwendung: | P-glycoprotein modulator |
CAS | 167465-36-3 |
MW: | 637 D |
ab 52,00 €
Artikelnummer: Cay18603-500
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma...
Schlagworte: | 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester... |
Anwendung: | MDR1 modulator, Chemosensitizer |
CAS | 174630-04-7 |
MW: | 641.8 D |
ab 46,00 €
Artikelnummer: Cay18128-10
Elacridar is a dual inhibitor of P-glycoprotein (MRP-1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). It maximally inhibits P-glycoprotein in isolated human peripheral blood leukocytes at 200 nM. Elacridar blocks the activity of P-glycoprotein at the blood-brain barrier, altering the pharmacokinetics of...
Schlagworte: | GF120918, GG918, GW0918,... |
Anwendung: | ABCB1 inhibitor, ABCG2 inhibitor |
CAS | 143664-11-3 |
MW: | 563.6 D |
ab 43,00 €
Artikelnummer: Cay22828-1
C6 NBD Lactosylceramide (d18:1/6:0) is a biologically active derivative of lactosylceramides (d18:1/acyl mixture) (Cay-16983) that is tagged with a fluorescent C-6 nitrobenzoxadiazole (C-6 NBD, Cay-18871) group. C6 NBD Lactosylceramide (d18:1/6:0) has been used to study the effects of P-glycoprotein inhibition in...
Schlagworte: | C6 NBD LacCer, C6 NBD Lactosylceramide, NBD LacCer(d18:1/6:0), NBD Lactosylceramide (d18:1/6:0),... |
Anwendung: | Enzyme assays, Fluorescence |
CAS | 474943-04-9 |
MW: | 900 D |
ab 432,00 €
Artikelnummer: AG-CN2-0506-C100
White to off-white lyophilized powder. Soluble in DMSO or 100% ethanol (25mg/ml). Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell, Reversing agent for...
Schlagworte: | NSC378977 |
Anwendung: | MDR1 inhibitor |
CAS | 78518-73-7 |
MW: | 476,7 D |
154,00 €
Artikelnummer: AG-CN2-0507-C100
White to off-white lyophilized powder. Soluble in DMSO or 100% ethanol (25mg/ml). Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell, Reversing agent for...
Schlagworte: | NSC 378978 |
Anwendung: | MDR1 inhibitor |
CAS | 877822-91-8 |
MW: | 474,7 D |
154,00 €
Artikelnummer: G-HUFI02031.96
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
641,00 €