Zu "K05658" wurden 193 Artikel gefunden!
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Anti-Recombinant MDR1, clone 5B3
Artikelnummer: E-AN300819L.100
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White)....
| Schlagworte: | Anti-ABCB1, Anti-P-glycoprotein 1, Anti-Multidrug resistance protein 1, Anti-Phospholipid transporter ABCB1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 258,00 €
Rhodamine 123 (chloride)
Artikelnummer: Cay16672-5
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp, also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp. As P-gp is expressed on a population of stem...
| Schlagworte: | R-22420, R-302, RH123, 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-xanthylium, monochloride |
| Anwendung: | Membrane-permeable cationic dye, P-glycoprotein substrate, mitochondrial stain |
| CAS | 62669-70-9 |
| MW: | 380.8 D |
ab 49,00 €
Tariquidar
Artikelnummer: Cay24180-100
Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine (Cay-11762) and paclitaxel (Cay-10461) in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug...
| Schlagworte: | XR9576,... |
| Anwendung: | P-Glycoprotein inhibitor |
| CAS | 206873-63-4 |
| MW: | 646.7 D |
ab 92,00 €
Anti-MDR1/ABCB1
Artikelnummer: A303-625A
Protein function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. [The UniProt Consortium]
| Schlagworte: | Anti-MDR1, Anti-ABCB1, Anti-CD243, EC=3.6.3.44, Anti-P-glycoprotein 1, Anti-Multidrug resistance protein 1,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Nobiletin
Artikelnummer: Cay15421-5
Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities. It reduces LPS- and IFN-gamma-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM. Nobiletin...
| Schlagworte: | NSC 618903, NSC 76751, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one |
| Anwendung: | Natural polymethoxylated flavonoid |
| CAS | 478-01-3 |
| MW: | 402.4 D |
ab 54,00 €
Zosuquidar (hydrochloride)
Artikelnummer: Cay21533-5
Zosuquidar is a modulator of P-glycoprotein (P-gp, Ki = 59 nM). It restores the sensitivity of P-gp-expressing cancer cells to vinblastine (Cay-11762), doxorubicin (Cay-15007), etoposide (Cay-12092), and paclitaxel (Cay-10461) when used at 0.1 µM. It less potently inhibits cytochrome P450 (CYP) isoforms CYP3A,...
| Schlagworte: | LY335979, RS 33295-198,... |
| Anwendung: | P-glycoprotein modulator |
| CAS | 167465-36-3 |
| MW: | 637 D |
ab 38,00 €
Reversin 121
Artikelnummer: Cay18603-500
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma...
| Schlagworte: | 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester... |
| Anwendung: | MDR1 modulator, chemosensitizer |
| CAS | 174630-04-7 |
| MW: | 641.8 D |
ab 52,00 €
Anti-P Glycoprotein
Artikelnummer: NSJ-R30136
0.5mg/ml if reconstituted with 0.2ml sterile DI water. P Glycoprotein, also called MDR1, P-GP, and PGY1, is a protein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. It is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular...
| Schlagworte: | Anti-MDR1, Anti-ABCB1, Anti-CD243, EC=3.6.3.44, Anti-P-glycoprotein 1, Anti-Multidrug resistance protein 1,... |
| Anwendung: | IHC (paraffin), IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Elacridar
Artikelnummer: Cay18128-10
Elacridar is a dual inhibitor of P-glycoprotein (MRP-1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). It maximally inhibits P-glycoprotein in isolated human peripheral blood leukocytes at 200 nM. Elacridar blocks the activity of P-glycoprotein at the blood-brain barrier, altering the pharmacokinetics of...
| Schlagworte: | GF120918, GG918, GW0918,... |
| Anwendung: | ABCB1 inhibitor, ABCG2 inhibitor |
| CAS | 143664-11-3 |
| MW: | 563.6 D |
ab 49,00 €
C6 NBD Lactosylceramide (d18:1/6:0)
Artikelnummer: Cay22828-1
C6 NBD Lactosylceramide (d18:1/6:0) is a biologically active derivative of lactosylceramides (d18:1/acyl mixture) (Cay-16983) that is tagged with a fluorescent C-6 nitrobenzoxadiazole (C-6 NBD, Cay-18871) group. C6 NBD Lactosylceramide (d18:1/6:0) has been used to study the effects of P-glycoprotein inhibition in...
| Schlagworte: | C6 NBD LacCer, C6 NBD Lactosylceramide, NBD LacCer(d18:1/6:0), NBD Lactosylceramide (d18:1/6:0),... |
| Anwendung: | Enzyme assays, fluorescence |
| CAS | 474943-04-9 |
| MW: | 900 D |
ab 480,00 €
Rhodamine 123
Artikelnummer: TGM-T16743-10mg
Description: Rhodamine 123 is a fluorescent dye (lambdaex=503 nm, lambdaem=527 nm). Target: Others. Smiles: COC(C1=CC=CC=C1C2=C3C=CC(N)=CC3=[O+]C4=C2C=CC(N)=C4)=O.[Cl-]. References: M. Huang, et al. Mitochondrial Inner Membrane Electrophysiology Assessed by Rhodamine-123 Transport and Fluorescence. Ann Biomed Eng....
| Schlagworte: | RH-123, R-22420 |
| Anwendung: | Membrane-permeable cationic dye, P-glycoprotein substrate, mitochondrial stain |
| CAS | 62669-70-9 |
| MW: | 380.83 D |
ab 45,00 €
Sipholenol A
Artikelnummer: AG-CN2-0506-C100
White to off-white lyophilized powder. Soluble in DMSO or 100% ethanol (25mg/ml). Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell, Reversing agent for...
| Schlagworte: | NSC378977 |
| Anwendung: | MDR1 inhibitor |
| CAS | 78518-73-7 |
| MW: | 476,7 D |
154,00 €