Zu "K05613" wurden 49 Artikel gefunden!
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DL-TBOA
Artikelnummer: Cay29632-10
DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 µM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively. It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 µM) and by L-glutamate in...
| Schlagworte: | DL-threo-beta-Benzyloxyaspartate, rel-3R-(phenylmethoxy)-D-aspartic acid |
| Anwendung: | Excitatory amino acid transporter (EAAT) inhibitor |
| CAS | 205309-81-5 |
| MW: | 239.2 D |
ab 274,00 €
TFB-TBOA (hydrate)
Artikelnummer: Cay31417-10
TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50 values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells. It is selective for EAAT1 and EAAT2 over EAAT3 (IC50 = 300 nM), as well as the choline, dopamine, GABA, norepinephrine,...
| Schlagworte: | CF3-Bza-TBOA, 3S-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]-(3S)-L-aspartic acid, monohydrate |
| Anwendung: | EAAT1 / EAAT2 inhibitor |
| MW: | 426.3 D |
ab 93,00 €
LDN-212320
Artikelnummer: TGM-T15728-25mg
Description: LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 µM after 24 h. Target: transporter. Smiles: Cc1ccccc1CSc1ccc(nn1)-c1ccccn1. References: Xing X, et al. Structure-activity relationship study of pyridazine derivatives as...
| Schlagworte: | LDN-0212320, OSU-0212320, LDN/OSU-0212320 |
| Anwendung: | EAAT2 expression activator |
| CAS | 894002-50-7 |
| MW: | 293.39 D |
ab 34,00 €
Anti-EAAT2
Artikelnummer: NSJ-R30166
0.5mg/ml if reconstituted with 0.2ml sterile DI water.
| Schlagworte: | Anti-EAAT2, Anti-SLC1A2, Anti-Solute carrier family 1 member 2, Anti-Glutamate/aspartate transporter II, Anti-Excitatory... |
| Anwendung: | WB, IF, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
LDN-0212320
Artikelnummer: Cay21650-10
LDN-0212320 is an activator of excitatory amino acid transporter 2 (EAAT2) that increases expression of EAAT2 in PA-EAAT2 cells in a concentration- and time-dependent manner (EC50 = 1.83 µM). It selectively increases EAAT2 protein levels over EAAT1 and EAAT3 protein levels and increases glutamate uptake in primary...
| Schlagworte: | OSU-0212320, 3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine |
| Anwendung: | EAAT2 expression activator |
| CAS | 894002-50-7 |
| MW: | 293.4 D |
ab 93,00 €
Dihydrokainic Acid
Artikelnummer: Cay28478-1
Dihydrokainic acid (DHK) is an inhibitor of excitatory amino acid transporter 2 (EAAT2, Ki = 23 µM for glutamate uptake by COS cells expressing EAAT2). It is selective for EAAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both). DHK microinfusion (5 nmol) into the rat infralimbic cortex reduces the time spent immobile in...
| Schlagworte: | DHK, (2S,3S,4R)-2-carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid |
| Anwendung: | EAAT2 inhibitor |
| CAS | 52497-36-6 |
| MW: | 215.2 D |
ab 56,00 €
GT 949
Artikelnummer: Cay34552-5
GT 949 is a positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2, EC50 = 0.26 nM for stimulating glutamate uptake by COS-7 cells expressing EAAT2). It is selective for EEAT2 over the serotonin (5-HT) transporter (SERT), the norepinephrine transporter (NET), and the dopamine transporter (DAT,...
| Schlagworte: | 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-2(1H)-quinolinone |
| Anwendung: | EEAT2 positive allosteric modulator |
| CAS | 460330-27-2 |
| MW: | 527.7 D |
139,00 €
Anti-SLC1A2
Artikelnummer: ATA-HPA009172.100
Protein function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+)...
| Schlagworte: | Anti-EAAT2, Anti-SLC1A2, Anti-Solute carrier family 1 member 2, Anti-Glutamate/aspartate transporter II, Anti-Excitatory... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Mouse EAAT2 (Excitatory Amino Acid Transporter 2) ELISA Kit
Artikelnummer: ELK-ELK6051.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse EAAT2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse EAAT2. Next,...
| Schlagworte: | Eaat2, GLT-1, Slc1a2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, Sodium-dependent... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 374,00 €
Human EAAT2 (Excitatory Amino Acid Transporter 2) ELISA Kit
Artikelnummer: ELK-ELK4324.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EAAT2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human EAAT2. Next,...
| Schlagworte: | Solute carrier family 1 member 2, Glutamate/aspartate transporter II, Excitatory amino acid transporter 2,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Rat EAAT2 (Excitatory Amino Acid Transporter 2) ELISA Kit
Artikelnummer: ELK-ELK7105.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat EAAT2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat EAAT2. Next,...
| Schlagworte: | Eaat2, GLT-1, Slc1a2, GLUT-R, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, Sodium-dependent... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 374,00 €
Anti-EAAT2
Artikelnummer: ELK-EA284.100
Excitatory amino acid transporters (EAATs) regulate and maintain extracellular glutamate concentrations below excitotoxic levels. In addition, glutamate transporters may limit the duration of synaptic excitation by an electrogenic process in which the transmitter is cotransported with three sodium ions and one...
| Schlagworte: | Anti-Solute carrier family 1 member 2, Anti-Glutamate/aspartate transporter II, Anti-Excitatory amino acid transporter 2,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
290,00 €