Zu "K05217" wurden 34 Artikel gefunden!
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alpha,beta-Methyleneadenosine 5'-triphosphate (sodium salt)
Artikelnummer: Cay10008956-10
alpha,beta-Methyleneadenosine 5'-triphosphate (alphabeta-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the alpha- and beta-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold...
| Schlagworte: | alphabeta-methylene ATP, 5'-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt |
| Anwendung: | P2X1 / P2X3 agonist |
| CAS | 1343364-54-4 |
| MW: | 571.2 D |
ab 93,00 €
AF-353 (hydrochloride)
Artikelnummer: Cay23034-5
AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells...
| Schlagworte: | Ro-4, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine |
| Anwendung: | P2X3 receptor antagonist |
| CAS | 927887-18-1 |
| MW: | 436.7 D |
ab 56,00 €
A-317491
Artikelnummer: Cay19256-1
A-317491 is a non-nucleotide antagonist of the purinergic receptors P2X3 and P2X2/3 (Kis = 22-92 nM in a calcium influx assay) that is selective over other purinergic and neurotransmitter receptors, ion channels, and enzymes (IC50s = >10 µM). It reduces thermal hyperalgesia induced by complete Freund's adjuvant in...
| Schlagworte: | 5-[[[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid |
| Anwendung: | Non-nucleotide P2X3 / P2X2/3 receptor antagonist |
| CAS | 475205-49-3 |
| MW: | 565.6 D |
ab 54,00 €
Anti-P2RX3
Artikelnummer: E-AB-13478.120
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary...
| Schlagworte: | Anti-P2X3, Anti-P2RX3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor, P2RX3 Polyclonal Antibody |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Anti-P2RX3
Artikelnummer: E-AB-70216.120
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary...
| Schlagworte: | Anti-P2X3, Anti-P2rx3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor, P2RX3 Polyclonal Antibody |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse, rat |
ab 195,00 €
RO-3
Artikelnummer: Cay29635-10
RO-3 is a dual antagonist of the purinergic receptor subtypes P2X3 and P2X2/3 (IC50s = 0.1 and 1.26 µM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 receptors (IC50s = >10 µM for all) but is an antagonist of ML1-type melatonin receptors (IC50 = 0.398 µM).Formal Name:...
| Schlagworte: | 5-[[4,5-dimethoxy-2-(1-methylethyl)phenyl]methyl]-2,4-pyrimidinediamine |
| Anwendung: | Purinergic receptor P2X3 /P2X2/3 dual antagonist |
| CAS | 1026582-88-6 |
| MW: | 302.4 D |
ab 122,00 €
Anti-P2RX3
Artikelnummer: ATA-HPA057776.100
Protein function: Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as...
| Schlagworte: | Anti-P2X3, Anti-P2RX3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
TNP-ATP (sodium salt)
Artikelnummer: Cay38492-3.6
TNP-ATP is a derivative of ATP and an antagonist of the purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50s = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing the human receptors). It is selective for these receptors over the purinergic P2X2, P2X4, and P2X7 receptors (IC50s = 2, 15.2, and >30 µM,...
| Schlagworte: | ((3a'R,4'R,6'R,6a'R)-4'-(6-amino-9H-purin-9-yl)-2,4,6-trinitro-3a',4',6',6a'-tetrahydrospiro[cyclohexane-1,2'-furo[3,4-d][... |
| Anwendung: | ATP derivative, purinergic P2Y1 / P2X3 / P2X2/3 antagonist |
| MW: | 806.2 D |
394,00 €
Gefapixant
Artikelnummer: Cay40825-1
Gefapixant is an allosteric antagonist of the purinergic P2X3 receptor. It inhibits agonist-induced P2X3 and P2X2/3 currents in 1321N1 cells co-expressing human P2X2 and P2X3 (IC50s = 153 and 220 nM, respectively) but does not inhibit P2X2 currents in the same cells at 10 µM. In vivo, gefapixant (30 mg/kg) increases...
| Schlagworte: | AF-219, MK-7264, Ro 4926219, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-benzenesulfonamide |
| Anwendung: | P2X3 receptor antagonist, analgesic, antitussive |
| CAS | 1015787-98-0 |
| MW: | 353.4 D |
ab 38,00 €
Anti-P2RX3
Artikelnummer: CSB-PA005140.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-P2X3, Anti-P2RX3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor, ATP receptor antibody,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-P2RX3
Artikelnummer: CSB-PA056352.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: P2RX3. Antigen Species: Human
| Schlagworte: | Anti-P2X3, Anti-P2RX3, Anti-ATP receptor, Anti-P2X purinoceptor 3, Anti-Purinergic receptor, ATP receptor antibody,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Gefapixant
Artikelnummer: TGM-T5099-100mg
Description: Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Target: P2X Receptor. Smiles: COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O. References: Ford AP, In pursuit of P2X3 antagonists: novel...
| Schlagworte: | RO 4926219 , AF219 , MK-7264 |
| Anwendung: | Targets P2X purinoceptor 3 (P2RX3) |
| CAS | 1015787-98-0 |
| MW: | 353.4 D |
ab 31,00 €