Zu "K05185" wurden 24 Artikel gefunden!
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3beta,5alpha-THDOC
Artikelnummer: Cay18431-5
3beta,5alpha-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ, Cay-18682), in mice (ED50s = 45.9 and >100 mg/kg, respectively). 3beta,5alpha-THDOC has been found in the urine of women during the third trimester of pregnancy.Formal Name:...
| Schlagworte: | 3beta,21-dihydroxy-5alpha-Pregnan-20-one, 3beta,5alpha-Tetrahydrodeoxycorticosterone, 3beta,5alpha-Tetrahydroprogesterone,... |
| Anwendung: | GABAA receptor modulator control |
| CAS | 567-01-1 |
| MW: | 334.5 D |
ab 49,00 €
Chlormethiazole (hydrochloride)
Artikelnummer: Cay33437-5
Chlormethiazole is a potentiator of GABAA receptors. It potentiates GABA-induced currents in L-M(TK-) cells expressing alpha1beta1gamma2 or alpha1beta2gamma2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock...
| Schlagworte: | Clomethiazole, 5-(2-chloroethyl)-4-methyl-thiazole, monohydrochloride |
| Anwendung: | GABAA receptors potentiator |
| CAS | 6001-74-7 |
| MW: | 198.1 D |
ab 56,00 €
6-(4-Methoxyphenyl)-3-pyridazinamine
Artikelnummer: Cay17588-50
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. 6-(4-Methoxyphenyl)-3-pyridazinamine is an...
| Schlagworte: | 6-(4-methoxyphenyl)-3-pyridazinamine |
| Anwendung: | GABAA receptor antagonist |
| CAS | 4776-87-8 |
| MW: | 201.2 D |
ab 93,00 €
Ganaxolone
Artikelnummer: Cay20919-5
Ganaxolone (Cay-20919) is an analytical reference standard categorized as a GABAA receptor positive allosteric modulator. Ganaxolone has anticonvulsant activity in mice. Ganaxolone is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.Formal Name:...
| Schlagworte: | CCD 1042, (3alpha,5alpha)-3-hydroxy-3-methyl-pregnan-20-one |
| Anwendung: | Allopregnanolone analog |
| CAS | 38398-32-2 |
| MW: | 332.5 D |
ab 49,00 €
Etifoxine
Artikelnummer: Cay15999-50
Etifoxine is a positive allosteric modulator of alpha1beta2gamma2 and alpha1beta3gamma2 subunit-containing GABAA receptors. It selectively increases GABA-induced currents in X. laevis oocytes expressing alpha1beta2gamma2 or alpha1beta3gamma2 over alpha1beta1gamma2 subunit-containing receptors at 20 µM. Etifoxine...
| Schlagworte: | Etafenoxine, HOE 36-801, 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3, 1-benzoxazin-2-amine |
| Anwendung: | Anxiolytic, positive allosteric GABA(A) receptor modulator |
| CAS | 21715-46-8 |
| MW: | 300.8 D |
ab 128,00 €
Bretazenil
Artikelnummer: Cay28411-5
Bretazenil is a positive allosteric modulator of GABAA receptors with anticonvulsant and anxiolytic activity. It potentiates GABA-gated chloride currents in rat cortical neurons and in HEK293 cells expressing alpha1beta1gamma2 subunit-containing GABAA receptors (EC50s = 60 and 10 nM, respectively). Bretazenil...
| Schlagworte: | Ro 16-6028, (13aS)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic... |
| Anwendung: | GABA-A receptor positive allosteric modulator |
| CAS | 84379-13-5 |
| MW: | 418.3 D |
ab 56,00 €
Flumazenil
Artikelnummer: LKT-F4681.5
Flumazenil is an imidazodiazepine the blocks the effects of benzodiazepines.
| Anwendung: | GABAA-receptor (benzodiazepine binding site) antagonist |
| CAS | 78755-81-4 |
| MW: | 303.29 D |
ab 104,00 €
Alpidem
Artikelnummer: Cay34252-5
Alpidem is an anxiolytic agent. It selectively binds to alpha1beta2gamma2 subunit-containing GABAA receptors over alpha5beta2gamma2 subunit-containing GABAA receptors in HEK293 cells (IC50s = 0.017 and >10 µM, respectively, for the recombinant rat receptors). Alpidem also binds to the GABAA/benzodiazepine receptor...
| Schlagworte: | 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide |
| Anwendung: | Anxiolytic agent, GABA-A receptor agonist |
| CAS | 82626-01-5 |
| MW: | 404.3 D |
ab 93,00 €
Anti-GABRE
Artikelnummer: ATA-HPA045918.100
Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative....
| Schlagworte: | Anti-GABRE, Anti-GABA(A) receptor subunit epsilon, Anti-Gamma-aminobutyric acid receptor subunit epsilon |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €
Anti-GABRE
Artikelnummer: CSB-PA004692.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-GABRE, Anti-GABA(A) receptor subunit epsilon, Anti-Gamma-aminobutyric acid receptor subunit epsilon, GABA(A) receptor... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
GABRE (human), recombinant protein
Artikelnummer: ABS-PP-25747.100
Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium]
| Schlagworte: | GABRE, GABA(A) receptor subunit epsilon, Gamma-aminobutyric acid receptor subunit epsilon |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 14 kD |
ab 90,00 €
GABRE (human), recombinant protein
Artikelnummer: ABS-PQ-700-L.100
Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium]
| Schlagworte: | Gamma-aminobutyric acid receptor subunit epsilon, GABA(A) receptor subunit epsilon, Recombinant Human GABRE Protein |
| Exprimiert in: | human cells |
| Ursprungsart: | human |
| MW: | 37 kD |
ab 295,00 €