Zu "K05126" wurden 116 Artikel gefunden!
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BLU-667
Artikelnummer: LKT-B465806.1
BLU-667 is an inhibitor of the rearranged during transfection (RET) kinase. RET is an oncogenic driver activated in multiple cancers. BLU-667 is an early selective small molecule designed to target RET, in contrast with current treatment methods that have been limited to multikinase inhibitors. BLU-667 potently...
| Schlagworte: | BLU 667, BLU667, Pralsetinib,... |
| Anwendung: | RET inhibitor |
| CAS | 2097132-94-8 |
| MW: | 533.61 D |
ab 143,00 €
Anti-RET
Artikelnummer: ABS-KC-3836.100
Protein function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival...
| Schlagworte: | Anti-Proto-oncogene tyrosine-protein kinase receptor Ret, Anti-Cadherin family member 12, Anti-Proto-oncogene c-Ret)... |
| Anwendung: | IP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Enbezotinib
Artikelnummer: TGM-T62285-100mg
Description: Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research. Target: c-RET. Smiles: [H][C@]12CCC[C@@]1([H])N1Cc3cc(F)cnc3O[C@@H](C)CNC(=O)c3cnn4cc(O2)c1nc34. References: ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| CAS | 2359649-81-1 |
| MW: | 424.43 D |
ab 122,00 €
Pralsetinib
Artikelnummer: TGM-TQ0277-1mg
Description: Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion). Target: c-RET. Smiles: CO[C@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1. References:...
| Schlagworte: | Blu667 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| CAS | 2097132-94-8 |
| MW: | 533.6 D |
ab 37,00 €
WHI-P180
Artikelnummer: TGM-T2032-1mg
Description: WHI-P180 (Janex 3) is a potent inhibitor of EGFR and Cdk2, with IC50 values of 4.0 µM and 1.0 µM, respectively. Target: CDK, EGFR, c-RET, VEGFR. Smiles: COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC. References: An R, et al. Pharm Res. 2009 Feb,26(2):449-58.
| Schlagworte: | Janex 3 |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 211555-08-7 |
| MW: | 297.31 D |
ab 40,00 €
Zeteletinib hemiadipate
Artikelnummer: TGM-T39927-5mg
Description: Zeteletinib hemiadipate (BOS-172738, DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various...
| Schlagworte: | Zeteletinib hemiadipate, DS-5010hemiadipate, BOS-172738 hemiadipate |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| CAS | 2375837-06-0 |
| MW: | 1147.098 D |
970,00 €
AST 487
Artikelnummer: TGM-T4053-100mg
Description: AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3. Target: VEGFR, c-Kit, FLT, c-RET, Bcr-Abl. Smiles: C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4. References:...
| Schlagworte: | NVP-AST 487 |
| Anwendung: | RET inhibitor |
| CAS | 630124-46-8 |
| MW: | 529.56 D |
ab 31,00 €
GSK3179106
Artikelnummer: TGM-T5491-100mg
Description: GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM. Target: c-RET. Smiles: CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1. References: Russell JP, et al. Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of...
| Anwendung: | RET inhibitor |
| CAS | 1627856-64-7 |
| MW: | 467.41 D |
ab 37,00 €
RET Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-02270-1mg
Description: RET Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.1 kDa and the accession number is P07949-1.
| Schlagworte: | MTC1, PTC, HSCR1, RET51, MEN2B, RET-ELE1, CDHR16, ret proto-oncogene, CDHF12, MEN2A |
| MW: | 69.1 kD |
ab 599,00 €
RET Protein, Human, Recombinant (aa 658-1114, His & GST)
Artikelnummer: TGM-TMPY-04418-50ug
Description: RET Protein, Human, Recombinant (aa 658-1114, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.7 kDa and the accession number is P07949-1.
| Schlagworte: | MEN2B, MTC1, CDHF12, PTC, RET-ELE1, CDHR16, MEN2A, ret proto-oncogene, HSCR1, RET51 |
| MW: | 76.7 kD |
497,00 €
Anti-RET (Capture/Detector)
Artikelnummer: E-AN000810P.1
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by...
| Schlagworte: | Anti-CDHF12, RET Polyclonal Antibody(Capture/Detector) |
| Anwendung: | ELISA Capture/Detector |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 158,00 €
Human RET Protein, His Tag
Artikelnummer: DIM-PME100736.10
Recombinant human RET protein with C-terminal 6×His tag. RET(Leu29-Arg635) 6×His tag, Protein function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived...
| Schlagworte: | Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| CAS | 12 |
| MW: | 68.6 kD |
ab 118,00 €