Zu "K05126" wurden 156 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
WHI-P180 (hydrochloride)
Artikelnummer: Cay44365-10
WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively. It also inhibits EGFR (IC50 = 4 µM) and binds to tau-tubulin kinase 1 (TTBK1, Kds = 0.46 and 0.24 µM for phosphorylated and non-phosphorylated TTBK1,...
| Schlagworte: | 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol, monohydrochloride |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 153437-55-9 |
| MW: | 333,77 D |
ab 57,00 €
RET-IN-3
Artikelnummer: Cay43193-10
A RETV804M inhibitor (IC50 = 19 nM). Formulation: A solid. InChI: InChI=1S/C18H21N5O2/c1-22(2)8-3-7-19-17-6-9-23-18(21-17)14(11-20-23)13-4-5-15-16(10-13)25-12-24-15/h4-6,9-11H,3,7-8,12H2,1-2H3,(H,19,21). InChIKey: DQYRQFLRDJTHQM-UHFFFAOYSA-N. SMILES: CN(C)CCCNC1=NC2=C(C3=CC=C4OCOC4=C3)C=NN2C=C1
| Schlagworte: | N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl-1,3-propanediamine |
| Anwendung: | RET(V804M) inhibitor |
| CAS | 2414374-53-9 |
| MW: | 339.4 D |
ab 414,00 €
SPP 86
Artikelnummer: Cay37390-1
A RET inhibitor (IC50 = 0.008 µM), selective for RET over a panel of 44 serine/threonine/tyrosine kinases at 10 µM but does inhibit nine by >75%, selective for RET over a panel of 63 receptor and non-receptor tyrosine kinases 0.4 µM but does inhibit six, including RET, by >75%, reduces the proliferation of HCT116...
| Schlagworte: | 1-(1-methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | RET inhibitor |
| CAS | 1357349-91-7 |
| MW: | 277.32 D |
ab 40,00 €
RET (human), recombinant protein (His Tag)
Artikelnummer: E-PDMH100184.1
Protein function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line- derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503,...
| Schlagworte: | CDHF12, Recombinant Human RET Protein(His Tag) |
| Exprimiert in: | Mammalian |
| Ursprungsart: | human |
ab 192,00 €
LOXO-292
Artikelnummer: Cay33515-5
LOXO-292 is an inhibitor of the receptor tyrosine kinase RET. It inhibits the phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM). LOXO-292 selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary...
| Schlagworte: | ARRY-192, Selpercatinib,... |
| Anwendung: | RET kinase inhibitor |
| CAS | 2152628-33-4 |
| MW: | 525.6 D |
ab 59,00 €
Regorafenib
Artikelnummer: SYN-1169-M100
Soluble in DMSO or ethanol. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR beta, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | BAY-73-4506 |
| Anwendung: | VEGFR2 / RET / Raf-1 inhibitor |
| CAS | 755037-03-7 |
| MW: | 482,8 D |
ab 123,00 €
RPI-1
Artikelnummer: Cay20384-10
RPI-1 is an ATP-dependent RET kinase inhibitor. It has been shown to selectively inhibit the anchorage-independent growth of NIH3T3 cells transformed by the ret/ptc1 oncogene with an IC50 value of 0.97 µM. In a spontaneously metastasizing lung carcinoma xenograft mouse model, daily oral treatment with RPI-1 was...
| Schlagworte: | 1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one |
| Anwendung: | ATP-dependent RET kinase inhibitor |
| CAS | 269730-03-2 |
| MW: | 297.3 D |
ab 51,00 €
Pralsetinib
Artikelnummer: Cay33181-1
Pralsetinib is an inhibitor of RET (IC50s = 0.4, 0.3, 0.4, and 0.4 nM for wild-type RET, RETV804L, RETV804M, and RETM918T, respectively). It is selective for RET over VEGFR2 (IC50 = 35 nM) and a panel of 371 kinases at 300 nM. Pralsetinib also inhibits a fusion protein of coiled-coil domain-containing protein 6 with...
| Schlagworte: | BLU-667,... |
| Anwendung: | RET inhibitor |
| CAS | 2097132-94-8 |
| MW: | 533.6 D |
ab 74,00 €
Pralsetinib
Artikelnummer: TGM-TQ0277-1mg
Description: Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion). Target: c-RET. Smiles: CO[C@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1. References:...
| Schlagworte: | Blu667 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| CAS | 2097132-94-8 |
| MW: | 533.6 D |
ab 35,00 €
Ret, active human recombinant protein
Artikelnummer: BPS-40267
Active human Ret (GenBank Accession No. NM_020975), (a.a. 658-end) with N-terminal GST tag, MW= 77.5 kDa, expressed in an Baculovirus infected Sf9 cell expression system.
| Schlagworte: | CDHF12, EC=2.7.10.1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 77.5 kD |
536,00 €
Human RET / Proto-oncogene tyrosine-protein kinase...
Artikelnummer: G-HUFI01452.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
4,4 -(1,1 -Biphenyl-4,4 -diyldioxy)dianiline
Artikelnummer: LKT-B3472.5
This compound may exhibit anti-angiogenic and anticancer benefit through the potential inhibition of VEGFR2 (Flk-1), Met, RET, Axl, Ron, PDGFR, FGFR1 (Flg), and FMS-related tyrosine kinases 1, 3, and 4 (FLT1/3/4).
| Schlagworte: | 4,4 -Bis(4-aminophenoxy)biphenyl |
| Anwendung: | VEGFR2 / Met / RET / Axl / Ron / PDGFR / FGFR1 / FLT1/3/4 inhibitor |
| CAS | 13080-85-8 |
| MW: | 368.43 D |
ab 100,00 €