Zu "K05121" wurden 124 Artikel gefunden!
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TIE2, His, Human
Artikelnummer: GSC-Z05880-100
Angiopoietin-1 (Ang-1) is the primary agonist for Tie2 tyrosine kinase receptor (Tie2), and the effect of Ang-1-Tie2 signalling is context-dependent. Deficiency in either Ang-1 or Tie2 protein leads to severe microvascular defects and subsequent embryonic lethality in murine model. Tie2 receptors are expressed in...
| Schlagworte: | TEK, p140 TEK, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tyrosine-protein kinase receptor TEK, Tunica interna... |
| Ursprungsart: | human |
| MW: | 82.09 kD |
ab 457,00 €
Human TIE2 ELISA Kit
Artikelnummer: ARG81419.96
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has...
| Schlagworte: | TEK, TIE2, hTIE2, CD202b, p140 TEK, EC=2.7.10.1, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tyrosine-protein... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
Mouse TIE2 ELISA Kit
Artikelnummer: ARG81794.96
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has...
| Schlagworte: | Hyk, HYK, Tek, STK1, mTIE2, CD202b, p140 TEK, EC=2.7.10.1, Angiopoietin-1 receptor, Endothelial tyrosine kinase,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.118,00 €
SB-633825
Artikelnummer: Cay43706-1
SB-633825 is a multi-kinase inhibitor. It inhibits tunica internal endothelial kinase 2 (Tie2), serine/threonine kinase 10 (STK10), and breast tumor kinase (BRK, IC50s = 3.5, 66, and 150 nM, respectively). InChI:...
| Schlagworte: | 4-[5-(6-methoxy-2-naphthalenyl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]-pyridine |
| Anwendung: | Multi-kinase (Tie2, STK10, BRK) inhibitor |
| CAS | 956613-01-7 |
| MW: | 483,59 D |
ab 81,00 €
Anti-Tie2/CD202b/TEK Monoclonal Recombinant Antibody
Artikelnummer: E-AN300201P.100
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to...
| Schlagworte: | hTIE2, CD202b, p140 TEK, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tyrosine-protein kinase receptor TEK,... |
| Anwendung: | FCM, ICC/IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Anti-TIE2
Artikelnummer: NSJ-F50680-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are...
| Schlagworte: | Anti-TEK, Anti-TIE2, Anti-hTIE2, Anti-CD202b, Anti-p140 TEK, EC=2.7.10.1, Anti-Angiopoietin-1 receptor, Anti-Endothelial... |
| Anwendung: | IHC, WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
RK-20448
Artikelnummer: Cay25606-5
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2 (IC50s = 0.24, 1.19, 10.74, and 5.85 µM, respectively). It also inhibits BLK, Csk, Fyn, and Lyn (IC50s = 0.37, 4.27, 2.03, and 0.43 µM, respectively). RK-20448 is the cis isomer of A-419259 (Cay-18168).Formal Name:...
| Schlagworte: | 7-[cis-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | ATP-competitive Lck / Src / VEGF2R / Tie-2 inhibitor |
| CAS | 479501-40-1 |
| MW: | 482.6 D |
ab 67,00 €
Pexmetinib
Artikelnummer: Cay26187-10
Pexmetinib is a dual inhibitor of Tie2 and p38 MAPK (IC50s = 1, 26, and 35 nM for Tie2, p38alpha, and p38beta, respectively). It also inhibits Abl, ARG, FGFR, FLT1, FLT4, Fyn, HCK, LYN, and MINK (IC50s = 4, 10, 28, 47, 42, 41, 26, 25, and 26 nM, respectively). Pexmetinib (0.5 and 1 µM) reduces proliferation of KG-1...
| Schlagworte: | ARRY 614,... |
| Anwendung: | Tie2 inhibitor, p38 MAPK inhibitor |
| CAS | 945614-12-0 |
| MW: | 556.6 D |
ab 56,00 €
Altiratinib
Artikelnummer: LKT-A4777.5
c-MET, Tie-2, VEGFR inhibitor.
| Schlagworte: | DCC-2701, DP-5164,... |
| Anwendung: | MET / TIE2 / VEGFR2 inhibitor |
| CAS | 1345847-93-9 |
| MW: | 510.46 D |
ab 116,00 €
Regorafenib N-oxide
Artikelnummer: Cay35101-1
Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib (Cay-18498). It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAF in vitro, as well as inhibits tumor growth in HT-29 and MDA-MB-231 mouse xenograft...
| Schlagworte: | 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-oxide |
| Anwendung: | Regorafenib active metabolite |
| CAS | 835621-11-9 |
| MW: | 498.8 D |
ab 49,00 €
Anti-TIE-2 (human), clone tek2
Artikelnummer: AG-20T-0102-C100
Native human TIE-2 in ELISA experiments and on the surface of different human cell types. Lyophilized. TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin...
| Schlagworte: | Anti-TEK, Anti-TIE2, Anti-VMCM, Anti-hTIE2, Anti-VMCM1, Anti-CD202b, EC=2.7.10.1, Anti-p140 TEK, Anti-Angiopoietin-1... |
| Anwendung: | ELISA, FC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
435,00 €
Anti-TIE-2 (human), clone tek9
Artikelnummer: AG-20T-0103-C100
Native human TIE-2 in ELISA experiments and on the surface of different human cell types. Lyophilized. TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin...
| Schlagworte: | Anti-TEK, Anti-TIE2, Anti-VMCM, Anti-hTIE2, Anti-VMCM1, Anti-CD202b, EC=2.7.10.1, Anti-p140 TEK, Anti-Angiopoietin-1... |
| Anwendung: | ELISA, FC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
435,00 €