Zu "K05117" wurden 88 Artikel gefunden!
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Anti-MerTK (human), Rabbit Monoclonal (RM506)
Artikelnummer: REV-31-1398-00-R100
MerTK is a transmembrane receptor tyrosine kinase (RTK) that is mainly expressed in dendritic cells (DCs) and macrophages. It is a member of the TYRO3/AXL/MER (TAM) receptor kinase family, which also includes TYRO3 and AXL. MerTK plays a role in a number of important biological processes, including phagocytosis,...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
483,00 €
Human MERTK (C-Mer Proto Oncogene Tyrosine Kinase) ELISA Kit
Artikelnummer: ELK-ELK3951.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MERTK. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MERTK. Next,...
| Schlagworte: | MER, MERTK, EC=2.7.10.1, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, Receptor tyrosine kinase MerTK |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Anti-MerTK (mouse), Rabbit Monoclonal (RM469)
Artikelnummer: REV-31-1361-00-R100
MerTK is a transmembrane receptor tyrosine kinase (RTK) that is mainly expressed in dendritic cells (DCs) and macrophages. It is a member of the TYRO3/AXL/MER (TAM) receptor kinase family, which also includes TYRO3 and AXL. MerTK plays a role in a number of important biological processes, including phagocytosis,...
| Schlagworte: | Anti-Mer, Anti-Mertk, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
483,00 €
UNC2025
Artikelnummer: Cay16613-5
UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...
| Schlagworte: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Anwendung: | Mer/FLT3 dual inhibitor |
| CAS | 1429881-91-3 |
| MW: | 476.7 D |
ab 95,00 €
UNC2250
Artikelnummer: Cay17703-1
Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM. It is selective for Mer...
| Schlagworte: | trans-4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-cyclohexanol |
| Anwendung: | Mer Kinase inhibitor |
| CAS | 1493694-70-4 |
| MW: | 440.6 D |
ab 43,00 €
UNC569
Artikelnummer: Cay22966-5
UNC569 is a potent inhibitor of the TAM family receptor tyrosine kinases Mer, Axl, and Tyro3 (IC50s = 2.9, 37, and 48 nM, respectively). It has antiproliferative activity in vitro against acute lymphoblastic leukemia (ALL) cells (IC50s = 0.5 and 1.2 µM for 697 and Jurkat cell lines, respectively) and inhibits Mer...
| Schlagworte: | 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine |
| Anwendung: | MERTK inhibitor |
| CAS | 1350547-65-7 |
| MW: | 396.5 D |
ab 50,00 €
MRX-2843
Artikelnummer: Cay27923-5
MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3, IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of...
| Schlagworte: | trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclo... |
| Anwendung: | Mer inhibitor, FLT3 inhibitor |
| CAS | 1429882-07-4 |
| MW: | 488.7 D |
ab 66,00 €
Anti-MERTK
Artikelnummer: ARG10783.50
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | IF, ELISA, FC, ICC, IF, IHC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
576,00 €
Anti-MERTK
Artikelnummer: ARG10784.50
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | IF, ELISA, FC, ICC, IF, IHC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
576,00 €
Anti-Phospho-MERTK
Artikelnummer: ARG10816.50
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-phospho-phospho--MER, Anti-phospho-phospho--MERTK, EC=2.7.10.1, Anti-phospho-phospho--Proto-oncogene c-Mer,... |
| Anwendung: | IF, ELISA, ICC, IF, IHC, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, monkey, mouse, rat |
592,00 €
Anti-MerTK/c-mer
Artikelnummer: A300-222A
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
c-Mer, GST-tag
Artikelnummer: BPS-40254
Human c-Mer, also known as tyrosine-protein kinase Mer, MERTK, and receptor tyrosine kinase MerTK GenBank Accession NM_006343, a.a. 578-872 with Cterminal GST-tag. Expressed in a baculovirus-infected Sf9 cell expression system. MW = 60 kDa.
| Schlagworte: | MER, MERTK, EC=2.7.10.1, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, Receptor tyrosine kinase MerTK, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 60 kD |
569,00 €