Zu "K05117" wurden 125 Artikel gefunden!
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MERTK/Mer Protein, Rat, Recombinant (His)
Artikelnummer: TGM-TMPH-04412-100ug
Description: MERTK/Mer Protein, Rat, Recombinant (His) is expressed in Mammalian cell. The accession number is P57097.
| Schlagworte: | Mertk , Receptor tyrosine kinase MerTK , Tyrosine-protein kinase Mer , Mer , Proto-oncogene c-Mer |
| MW: | 55.5 kD |
ab 229,00 €
Mouse MERTK ELISA Kit
Artikelnummer: ARG81750.96
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Mer, Mertk, EC=2.7.10.1, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, Receptor tyrosine kinase MerTK |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.118,00 €
Anti-MERTK (mouse) Rabbit (Clone RM469)
Artikelnummer: Cay42835-100
MERTK is a TAM family receptor tyrosine kinase with roles in macrophage activation, apoptotic cell engulfment, and platelet aggregation. It is composed of an extracellular domain, which contains two immunoglobulin-like (Ig-like) domains and two FNIII domains, and an intracellular tyrosine kinase domain. MERTK is...
| Schlagworte: | c-Mer, MER, Proto-oncogene c-Mer, Receptor Tyrosine Kinase MerTK, RP38, Tyrosine-protein Kinase Mer |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
571,00 €
UNC2025
Artikelnummer: Cay16613-5
UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...
| Schlagworte: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Anwendung: | Mer/FLT3 dual inhibitor |
| CAS | 1429881-91-3 |
| MW: | 476.7 D |
ab 116,00 €
UNC2250
Artikelnummer: Cay17703-1
Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM. It is selective for Mer...
| Schlagworte: | trans-4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-cyclohexanol |
| Anwendung: | Mer Kinase inhibitor |
| CAS | 1493694-70-4 |
| MW: | 440.6 D |
ab 51,00 €
UNC569
Artikelnummer: Cay22966-5
UNC569 is a potent inhibitor of the TAM family receptor tyrosine kinases Mer, Axl, and Tyro3 (IC50s = 2.9, 37, and 48 nM, respectively). It has antiproliferative activity in vitro against acute lymphoblastic leukemia (ALL) cells (IC50s = 0.5 and 1.2 µM for 697 and Jurkat cell lines, respectively) and inhibits Mer...
| Schlagworte: | 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine |
| Anwendung: | MERTK inhibitor |
| CAS | 1350547-65-7 |
| MW: | 396.5 D |
ab 58,00 €
MRX-2843
Artikelnummer: Cay27923-5
MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3, IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of...
| Schlagworte: | trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclo... |
| Anwendung: | Mer inhibitor, FLT3 inhibitor |
| CAS | 1429882-07-4 |
| MW: | 488.7 D |
ab 76,00 €
UNC2881
Artikelnummer: Cay29012-5
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 =...
| Schlagworte: | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide |
| Anwendung: | Mer inhibitor |
| CAS | 1493764-08-1 |
| MW: | 463.6 D |
ab 164,00 €
Anti-MERTK
Artikelnummer: ARG10783.50
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | IF, ELISA, FC, ICC, IF, IHC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
608,00 €
Anti-MERTK
Artikelnummer: ARG10784.50
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | IF, ELISA, FC, ICC, IF, IHC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
608,00 €
Anti-Phospho-MERTK
Artikelnummer: ARG10816.50
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-phospho-phospho--MER, Anti-phospho-phospho--MERTK, EC=2.7.10.1, Anti-phospho-phospho--Proto-oncogene c-Mer,... |
| Anwendung: | IF, ELISA, ICC, IF, IHC, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, monkey, mouse, rat |
641,00 €
Anti-MerTK/c-mer
Artikelnummer: A300-222A
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells...
| Schlagworte: | Anti-MER, Anti-MERTK, EC=2.7.10.1, Anti-Proto-oncogene c-Mer, Anti-Tyrosine-protein kinase Mer, Anti-Receptor tyrosine... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €