Zu "K05094" wurden 142 Artikel gefunden!
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Anti-FGFR3
Artikelnummer: NSJ-R31262
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Fibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between...
| Schlagworte: | Anti-FGFR3, Anti-Fibroblast growth factor receptor 3, FGFR3 Antibody |
| Anwendung: | WB, IHC (paraffin), ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
790,00 €
FGFR3, GST-tag
Artikelnummer: BPS-40212
Human FGFR3, (GenBank Accession #NM_000142) with N-terminal GST-tag, a.a 397-end, MW= 73 kDa, expressed in Sf9 cells via a baculovirus expression system.
| Schlagworte: | JTK4, CD333, FGFR3, FGFR-3, EC=2.7.10.1, Fibroblast growth factor receptor 3, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 73 kD |
901,00 €
BGJ398
Artikelnummer: Cay19157-1
BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively). It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 µM). BGJ398...
| Schlagworte: | NVP-BGJ398, Infigratinib,... |
| Anwendung: | FGFR1 / FGFR2 / FGFR3 inhibitor |
| CAS | 872511-34-7 |
| MW: | 560.5 D |
ab 93,00 €
Roridin E
Artikelnummer: Cay26955-1
Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRbeta, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 µM, respectively). Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM) and...
| Schlagworte: | (2'E,7'R)-2',3'-didehydro-7'-deoxo-2'-deoxy-7'-[(1R)-1-hydroxyethyl]-verrucarin A |
| Anwendung: | Macrocyclic trichothecene mycotoxin, FGFR3/IGF-1R/PDGFRbeta/TrkB inhibitor |
| CAS | 16891-85-3 |
| MW: | 514.6 D |
ab 247,00 €
PD 173074
Artikelnummer: Cay13032-25
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50...
| Schlagworte: | N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
| Anwendung: | FGFR inhibitor |
| CAS | 219580-11-7 |
| MW: | 523.7 D |
ab 58,00 €
JNJ-42756493
Artikelnummer: Cay21813-25
JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...
| Schlagworte: | Erdafitinib, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
| Anwendung: | FGFR inhibitor |
| CAS | 1346242-81-6 |
| MW: | 446.6 D |
ab 48,00 €
Anti-FGFR-3
Artikelnummer: ARG53020.500
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is...
| Schlagworte: | Anti-JTK4, Anti-CD333, Anti-FGFR3, Anti-FGFR-3, EC=2.7.10.1, Anti-Fibroblast growth factor receptor 3 |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
625,00 €
Human FGFR3 / CD333 / FGF Receptor 3 ELISA Kit
Artikelnummer: G-HUFI02460.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
S49076 HCl
Artikelnummer: SYN-1217-M100
Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block...
| Schlagworte: | S-49076 . HCl, (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione... |
| Anwendung: | MET AXL/MER & FGFR1/2/3 inhibitor |
| CAS | 1265965-19-2 |
| MW: | 475,0 D |
ab 123,00 €
CH5183284
Artikelnummer: Cay17120-5
CH5183284 is a potent, selective inhibitor of the kinase activity of fibroblast growth factor receptors (FGFRs) 1, 2, and 3 (IC50s = 9.3, 7.6, and 22 nM, respectively). It less potently inhibits FGFR4 and platelet-derived growth factor receptor beta (IC50s = 290 and 560 nM, respectively) and displays IC50 values...
| Schlagworte: | Debio 1347, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl-methanone |
| Anwendung: | FGFR1/2/3 inhibitor |
| CAS | 1265229-25-1 |
| MW: | 356.4 D |
ab 73,00 €
AZD 4547
Artikelnummer: Cay13111-50
AZD 4547 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase with IC50 values of 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively. It displays weaker activity against FGFR4 (IC50 = 165 nM), VEGFR2 (IC50 = 24 nM), and a panel of other tyrosine and serine/theronine kinases...
| Schlagworte: | rel-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-benzamide |
| Anwendung: | FGFR inhibitor |
| CAS | 1035270-39-3 |
| MW: | 463.6 D |
ab 163,00 €
Anti-FGFR3
Artikelnummer: E-AB-15633.120
Receptor for acidic and basic fibroblast growth factors. Preferentially binds FGF1. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in...
| Schlagworte: | Anti-JTK4, Anti-CD333, Anti-FGFR3, Anti-FGFR-3, EC=2.7.10.1, Anti-Fibroblast growth factor receptor 3, FGFR3 Polyclonal... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €