Zu "K05093" wurden 165 Artikel gefunden!
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Anti-Recombinant FGFR2, clone A221
Artikelnummer: E-AN301522L.100
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb...
| Schlagworte: | Anti-FGFR2, Anti-K-sam, Anti-Fibroblast growth factor receptor 2, Anti-Keratinocyte growth factor receptor, Recombinant... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
Human FGFR2 ELISA Kit
Artikelnummer: ARG82606.96
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning,...
| Schlagworte: | BEK, KGFR, K-sam, FGFR2, CD332, FGFR-2, Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
912,00 €
FGF-R2beta Fc Chimera, Mouse
Artikelnummer: GSC-Z03545-1
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 is a receptor for fibroblast growth factor and it has important roles in embryonic development and tissue repair, especially bone and blood vessels. FGFR2 has two naturally occurring isoforms, FGFR2IIIb and FGFR2IIIc, created by splicing of the third...
| Schlagworte: | Fgfr2, Keratinocyte growth factor receptor, Fibroblast growth factor receptor 2 |
| Ursprungsart: | mouse |
ab 214,00 €
FGFR2, active human recombinant protein
Artikelnummer: BPS-40211
Active human FGFR2 (GenBank Accession No. NM_000141), (a.a. 399-end) with N-terminal GST tag, MW= 74 kDa, expressed in baculovirus expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ- 35 and...
| Schlagworte: | BEK, KGFR, K-sam, FGFR2, CD332, FGFR-2, Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 74 kD |
566,00 €
LY2874455
Artikelnummer: Cay20843-25
LY2874455 is a pan-inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases with IC50 values of 2.8, 2.6, 6.4, 6, and 7 nM for FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2, respectively. It has been shown to inhibit proliferation of KMS-11, OPM-2, SNU-16, and KATO-III cancer cells in vitro and in tumor...
| Schlagworte: | 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol |
| Anwendung: | FGFR inhibitor |
| CAS | 1254473-64-7 |
| MW: | 444.3 D |
ab 111,00 €
PD 173074
Artikelnummer: Cay13032-10
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50...
| Schlagworte: | N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
| Anwendung: | FGFR inhibitor |
| CAS | 219580-11-7 |
| MW: | 523.7 D |
ab 58,00 €
AZD 4547
Artikelnummer: Cay13111-5
AZD 4547 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase with IC50 values of 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively. It displays weaker activity against FGFR4 (IC50 = 165 nM), VEGFR2 (IC50 = 24 nM), and a panel of other tyrosine and serine/theronine kinases...
| Schlagworte: | rel-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-benzamide |
| Anwendung: | FGFR inhibitor |
| CAS | 1035270-39-3 |
| MW: | 463.6 D |
ab 163,00 €
JNJ-42756493
Artikelnummer: Cay21813-1
JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...
| Schlagworte: | Erdafitinib, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
| Anwendung: | FGFR inhibitor |
| CAS | 1346242-81-6 |
| MW: | 446.6 D |
ab 48,00 €
FIIN-2
Artikelnummer: Cay19837-1
FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1...
| Schlagworte: | N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)... |
| Anwendung: | FGFR inhibitor |
| CAS | 1633044-56-0 |
| MW: | 634.7 D |
ab 67,00 €
Alofanib
Artikelnummer: Cay31754-5
Alofanib is an allosteric inhibitor of FGFR2. It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2alpha) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF, IC50 = 11...
| Schlagworte: | RPT835, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-benzoic acid |
| Anwendung: | Allosteric FGFR2 inhibitor |
| CAS | 1612888-66-0 |
| MW: | 413.4 D |
ab 128,00 €
Pemigatinib
Artikelnummer: Cay33260-1
Pemigatinib is an inhibitor of FGFR (IC50s = 0.4, 0.5, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively). It is selective for FGFR1, FGFR2, and FGFR3 over FGFR4 and the kinase insert domain receptor (KDR, IC50s = 30 and 70 nM, respectively), as well as over a panel of 56 tyrosine and serine/threonine kinases at 10...
| Schlagworte: | INCB054828,... |
| Anwendung: | FGFR inhibitor |
| CAS | 1513857-77-6 |
| MW: | 487.5 D |
ab 72,00 €
PRN-1371
Artikelnummer: Cay33787-1
PRN-1371 is an irreversible covalent pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively). It is selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit colony stimulating factor 1 receptor (CSF1R) activity by...
| Schlagworte: | 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]propyl]-pyrido[2,3-d]pyri... |
| Anwendung: | Irreversible pan-FGFR inhibitor |
| CAS | 1802929-43-6 |
| MW: | 561.5 D |
ab 104,00 €