Zu "K05088" wurden 61 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Taletrectinib
Artikelnummer: Cay45040-1
An ROS1, TrkA, and TrkC inhibitor (IC50s = 0.207, 0.622, and 0.98 nM, respectively), selective for these kinases over TrkB (IC50 = 2.28 nM), reduces the viability of JFCR-165, JFCR-168, and MGH193-1B patient-derived ROS1-CD74 fusion protein-positive NSCLC cells from 1-10,000 nM, reduces tumor volume in Ba/F3 mouse...
| Schlagworte: | AB-106, DS-6051b, 3-[4-[(2R)-2-aminopropoxy] phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-Imidazo[1,2-b]pyridazin-6-amine |
| Anwendung: | ROS1 / TrkA / TrkC inhibitor |
| CAS | 1505514-27-1 |
| MW: | 405.48 D |
ab 133,00 €
ROS1 Kinase Assay Kit
Artikelnummer: BPS-78189
The ROS1 Kinase Assay Kit is designed to measure ROS1 activity for screening and profiling applications using Kinase-Glo(R) MAX as a detection reagent. The signal is measured using a luminometer or a microplate reader capable of reading chemiluminescence.
| Schlagworte: | ROS, c-Ros Oncogene 1, MCF3, MCF3 kit, ROS kit, ROS assay kit, MCF3 assay kit, |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
TPX-0005
Artikelnummer: Cay23397-1
TPX-0005 is a multi-kinase inhibitor that inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as C-ros oncogene 1 (ROS1, IC50 = 0.07 nM). It inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively). It...
| Schlagworte: | (7S,13R)-11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4... |
| Anwendung: | ATP-competitive ALK/ROS1/TRK inhibitor |
| CAS | 1802220-02-5 |
| MW: | 355.4 D |
ab 49,00 €
Anti-ROS1
Artikelnummer: ARG55598.100
Protein function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR...
| Schlagworte: | Anti-MCF3, Anti-ROS1, EC=2.7.10.1, Anti-Proto-oncogene c-Ros, Anti-Proto-oncogene c-Ros-1, Anti-c-Ros receptor tyrosine... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
ROS1, active human recombinant protein, N-terminal GST tag
Artikelnummer: BPS-40268
Human Proto-oncogene c-Ros-1 (ROS1), also known as MCF3, GenBank Accession No. NM_002944), amino acids 1883-2347(end) with N-terminal GST-tag, MW= 78 kDa, expressed in Sf9 cells via a baculovirus expression system. Specific Activity is 8 pmole/min/µg.
| Schlagworte: | ROS1, MCF3, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, c-Ros receptor tyrosine kinase, Receptor tyrosine kinase c-ros... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 65 kD |
551,00 €
ASP3026
Artikelnummer: Cay18491-5
ASP3026 is an inhibitor of anaplastic lymphoma kinase (ALK, IC50s = 3.5, 10, and 5.4 nM for the wild-type, ALKF1174L, and ALKR1275Q enzymes, respectively). It is selective for ALK over a panel of 86 kinases at 1,000 nM but also inhibits c-Ros oncogene 1 (ROS1) and tyrosine kinase non-receptor 2 (TNK2, IC50s = 8.9...
| Schlagworte: | N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4... |
| Anwendung: | ALK / ACK inhibitor |
| CAS | 1097917-15-1 |
| MW: | 580.7 D |
ab 58,00 €
Anti-ROS1
Artikelnummer: NSJ-F52830-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival...
| Schlagworte: | Anti-MCF3, Anti-ROS1, EC=2.7.10.1, Anti-Proto-oncogene c-Ros, Anti-Proto-oncogene c-Ros-1, Anti-c-Ros receptor tyrosine... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
PF-06463922
Artikelnummer: Cay18371-10
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = i = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant...
| Schlagworte: | Lorlatinib,... |
| Anwendung: | ALK / ROS1 inhibitor |
| CAS | 1454846-35-5 |
| MW: | 406.4 D |
ab 56,00 €
Anti-ROS1
Artikelnummer: E-AB-12856.120
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor...
| Schlagworte: | Anti-MCF3, Anti-ROS1, EC=2.7.10.1, Anti-Proto-oncogene c-Ros, Anti-Proto-oncogene c-Ros-1, Anti-c-Ros receptor tyrosine... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Anti-ROS1
Artikelnummer: ATA-HPA049098.100
Protein function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR...
| Schlagworte: | Anti-ROS1, Anti-MCF3, EC=2.7.10.1, Anti-Proto-oncogene c-Ros, Anti-Proto-oncogene c-Ros-1, Anti-c-Ros receptor tyrosine... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-ROS1, clone SQab22273
Artikelnummer: ARG66943.50
Protein function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR...
| Schlagworte: | Anti-ROS1, Anti-MCF3, Anti-Proto-oncogene c-Ros, Anti-Proto-oncogene c-Ros, Anti-Proto-oncogene c-Ros-1,... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
773,00 €
ROS1 (G2032R), GST-Tag Recombinant
Artikelnummer: BPS-101640
Recombinant human ROS1 (G2032R) (ROS proto-oncogene 1, receptor tyrosine kinase), encompassing amino acids 1881-end. This construct contains an N-terminal GST-tag and was affinity purified.
| Schlagworte: | ROS1, MCF3, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, c-Ros receptor tyrosine kinase, Receptor tyrosine kinase c-ros... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling, contains mutation of interest |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 82 kD |
922,00 €