Zu "K05082" wurden 26 Artikel gefunden!
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Anti-MPL / Thrombopoietin Receptor (N-Terminal Region)
Artikelnummer: NSJ-F54100-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Myeloproliferative leukemia protein (MPL) is the receptor for Thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [UniProt] Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and...
| Schlagworte: | Anti-MPL, Anti-TPOR, Anti-TPO-R, Anti-CD110, Anti-Proto-oncogene c-Mpl, Anti-Thrombopoietin receptor,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Lusutrombopag
Artikelnummer: Cay26533-1
Lusutrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl. Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in...
| Schlagworte: | (2E)-3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-pro... |
| Anwendung: | Thrombopoietin receptor agonist |
| CAS | 1110766-97-6 |
| MW: | 591.5 D |
ab 61,00 €
Eltrombopag
Artikelnummer: Cay13247-1
Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in N2C-Tpo cells when used at a concentration of 30 µM and p42/44 MAPK phosphorylation when used at 10 µM. Eltrombopag binds to the...
| Schlagworte: | SB 497115,... |
| Anwendung: | TpoR agonist |
| CAS | 496775-61-2 |
| MW: | 442.5 D |
ab 43,00 €
Eltrombopag-13C4
Artikelnummer: Cay26114-1
Eltrombopag-13C4 is intended for use as an internal standard for the quantification of eltrombopag (Cay-13247) by GC- or LC-MS. Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in...
| Schlagworte: | (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-(methyl-13C)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene-3,4,5-13C3)hydrazineyl)-2'-hydroxy... |
| Anwendung: | GC-MS, LC-MS, internal standard, TpoR agonist |
| MW: | 446.4 D |
ab 310,00 €
Mouse MPL / TPOR ELISA Kit
Artikelnummer: ARG82349.96
Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt Consortium]
| Schlagworte: | Mpl, Tpor, TPO-R, CD110, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.416,00 €
Avatrombopag
Artikelnummer: Cay26535-10
Avatrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing the thrombopoietin receptor (EC50 = 3.3 nM) and induces differentiation of hematopoietic progenitor cells into megakaryotes. Avatrombopag is species-specific, inducing STAT5 phosphorylation in human and...
| Schlagworte: | AKR 501, AS 1670542, YM477,... |
| Anwendung: | Thrombopoietin receptor agonist |
| CAS | 570406-98-3 |
| MW: | 649.7 D |
ab 125,00 €
Anti-MPL
Artikelnummer: G-CAB16715.100
WB 1:500 - 1:2000. Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt Consortium]
| Schlagworte: | Anti-MPL, Anti-TPOR, Anti-CD110, Anti-TPO-R, Anti-Proto-oncogene c-Mpl, Anti-Thrombopoietin receptor,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 352,00 €
Anti-TPO-R/CD110/c-Mpl
Artikelnummer: G-CAB19729.100
Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt Consortium]
| Schlagworte: | Anti-MPL, Anti-TPOR, Anti-TPO-R, Anti-CD110, Anti-Proto-oncogene c-Mpl, Anti-Thrombopoietin receptor,... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 352,00 €
![TPOR Reporter Assay System [Human]](https://www.biomol.com/media/image/7b/6d/06/IB-IB20001_200x200.png "TPOR Reporter Assay System [Human]")
TPOR Reporter Assay System [Human]
Artikelnummer: IB-IB20001
This assay utilizes proprietary human cells that provide constitutive expression fo the Human Thrombopoietin Receptor (TPOR). TPOR, also known as MPL or CD110, is a member of the type I cytokine receptor superfamily. Thrombopoietin (TPO), the physiological activator of TPOR, is a glycoprotein that regulates...
| Schlagworte: | MPL, TPOR, CD110, TPO-R, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
![TPOR Reporter Assay System [Human]](https://www.biomol.com/media/image/04/85/f6/IB-IB20002_200x200.png "TPOR Reporter Assay System [Human]")
TPOR Reporter Assay System [Human]
Artikelnummer: IB-IB20002
This assay utilizes proprietary human cells that provide constitutive expression fo the Human Thrombopoietin Receptor (TPOR). TPOR, also known as MPL or CD110, is a member of the type I cytokine receptor superfamily. Thrombopoietin (TPO), the physiological activator of TPOR, is a glycoprotein that regulates...
| Schlagworte: | MPL, TPOR, CD110, TPO-R, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
3.802,00 €
Anti-TPO-R/CD110/c-Mpl
Artikelnummer: E-AB-91618.120
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with...
| Schlagworte: | MPL, TPOR, CD110, TPO-R, Proto-oncogene c-Mpl, Thrombopoietin receptor, Myeloproliferative leukemia protein,... |
| Anwendung: | WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 198,00 €
Anti-phospho-TPOR (Tyr626)
Artikelnummer: ELK-ES12601.100
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with...
| Schlagworte: | Anti-phospho-MPL, Anti-phospho-TPOR, Anti-phospho-CD110, Anti-phospho-TPO-R, Anti-phospho-Proto-oncogene c-Mpl,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse, |
ab 169,00 €