Zu "K05050" wurden 34 Artikel gefunden!

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SB 225002
SB 225002

Artikelnummer: Cay13336-10

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene alpha (Gro-alpha, CXCL1). IL-8 and Gro-alpha are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB...
Schlagworte: N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea
Anwendung: CXCR2 antagonist
CAS 182498-32-4
MW: 352.1 D
ab 110,00 €
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Danirixin
Danirixin

Artikelnummer: Cay20980-25

Danirixin is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2, IC50 = 12.5 µM). It is selective for CXCR2 over CXCR1 (IC50 = 977 nM). Danirixin inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52). It inhibits neutrophil surface expression of CD11b in isolated rat...
Schlagworte: GSK1325756, GSK1325756B, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-urea
Anwendung: Antiinflammatory, Chemokine (C-X-C motif) receptor 2 antagonist
CAS 954126-98-8
MW: 441.9 D
ab 54,00 €
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Reparixin (L-Lysine salt)
Reparixin (L-Lysine salt)

Artikelnummer: Cay21492-1

Reparixin is a non-competitive allosteric inhibitor of the activation of CXCR1 and CXCR2 chemokine receptors by IL-8 (IC50s = 1 and 100 nM, respectively). It blocks a range of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting...
Schlagworte: Repertaxin, (alphaR)-alpha-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide, L-lysine
Anwendung: Noncompetitive allosteric CXCR1 / CXCR2 inhibitor
CAS 266359-93-7
MW: 429.6 D
ab 35,00 €
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SB 265610
SB 265610

Artikelnummer: Cay17879-10

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and many other CXC chemokines involved in the trafficking and activation of inflammatory cells. It is involved in various inflammatory diseases, including chronic obstructive pulmonary disease,...
Schlagworte: N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-urea
Anwendung: Allosteric, inverse CXCR2 agonist
CAS 211096-49-0
MW: 357.2 D
ab 130,00 €
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Antileukinate
Antileukinate

Artikelnummer: Cay17359-1

Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 µM), prevents neutrophil chemotaxis and beta-glucuronidase release, and blocks...
Schlagworte: N2-acetyl-L-arginyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-cysteinyl-L-argininamide
Anwendung: CXCR2 antagonist
CAS 138559-60-1
MW: 1003.2 D
ab 161,00 €
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AZD 5069
AZD 5069

Artikelnummer: Cay28297-5

AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2, IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 µmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil...
Schlagworte: N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-1-azetidinesulfonamide
Anwendung: CXCR2 antagonist
CAS 878385-84-3
MW: 476.5 D
ab 44,00 €
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Anti-CXCR2
Anti-CXCR2

Artikelnummer: ARG10829.50

Protein function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also...
Schlagworte: Anti-CXCR2, Anti-IL8RB, Anti-CD182, Anti-CXCR-2, Anti-CXC-R2, Anti-CDw128b, Anti-IL-8R B, Anti-GRO/MGSA receptor,...
Anwendung: FC, ICC, IF, IHC (paraffin), IHC (frozen), IP, WB
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
576,00 €
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Anti-CXCR2
Anti-CXCR2

Artikelnummer: NSJ-R30204

0.5mg/ml if reconstituted with 0.2ml sterile DI water. CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family(subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that...
Schlagworte: Anti-CD182, Anti-CXCR2, Anti-IL8RB, Anti-CXCR-2, Anti-CXC-R2, Anti-IL-8R B, Anti-CDw128b, Anti-GRO/MGSA receptor,...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human, rat
755,00 €
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Anti-Cxcr2
Anti-Cxcr2

Artikelnummer: NSJ-R33768-100UG

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Chemokine (C-X-C motif) receptor 2, CD128 Protein function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of...
Schlagworte: Anti-CD182, Anti-IL8RB, Anti-CXCR2, Anti-CXC-R2, Anti-CXCR-2, Anti-CDw128b, Anti-IL-8R B, Anti-GRO/MGSA receptor,...
Anwendung: WB, ELISA (peptide)
Wirt: Goat
Spezies-Reaktivität: mouse
755,00 €
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Human CXCR2 (CXC-Chemokine Receptor 2) ELISA Kit
Human CXCR2 (CXC-Chemokine Receptor 2) ELISA Kit

Artikelnummer: G-HUES03382.96

ELISA Type: Sandwich. Sensitivity: 0.469ng/mL. Range: 0.781--50ng/mL. Protein function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a...
Schlagworte: IL8RB, CD182, CXCR2, CXCR-2, CXC-R2, IL-8R B, CDw128b, GRO/MGSA receptor, IL-8 receptor type 2, C-X-C chemokine receptor...
Anwendung: Sandwich ELISA
Spezies-Reaktivität: human
641,00 €
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Mouse IL8Rb (Interleukin 8 Receptor Beta) ELISA kit
Mouse IL8Rb (Interleukin 8 Receptor Beta) ELISA kit

Artikelnummer: G-MOES01751.96

ELISA Type: Sandwich. Sensitivity: 18.75pg/mL. Range: 31.25--2000pg/mL. Protein function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a...
Schlagworte: Cxcr2, CD182, CXCR-2, Cmkar2, CXC-R2, IL-8R B, GRO/MGSA receptor, C-X-C chemokine receptor type 2, High affinity...
Anwendung: Sandwich ELISA
Spezies-Reaktivität: mouse
694,00 €
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SB-332235
SB-332235

Artikelnummer: Cay32869-1

SB-332235 is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2, IC50 = 9.3 nM in CHO cell membranes expressing the recombinant human receptor). It is selective for CXCR2 over CXCR1 (IC50 = 9,633 nM). SB-332235 (10 ng/ml) inhibits migration of isolated human peripheral blood monocytes induced by chemokine...
Schlagworte: 6-chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxy-benzenesulfonamide
Anwendung: CXCR2 antagonist
CAS 276702-15-9
MW: 410.7 D
ab 60,00 €
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