Zu "K05038" wurden 37 Artikel gefunden!
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Opiranserin (hydrochloride)
Artikelnummer: Cay45056-1
A non-opioid analgesic, an inhibitor of GlyT2 (IC50 = 0.86 µM), antagonist of 5-HT2A and P2X3 (IC50s = 1.3 and 0.87 µM, respectively), reduces mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 80 mg/kg). SMILES: COC1=CC(C(NCC2(N(C)C)CCOCC2)=O)=CC(OC)=C1OCCCC.Cl. InChi...
| Schlagworte: | VVZ-149, 4-butoxy-N-[[4-(dimethylamino)tetrahydro-2H-pyran-4- yl]methyl]-3,5-dimethoxy-benzamide, monohydrochloride |
| Anwendung: | Non-opioid analgesic, GlyT2 inhibitor |
| CAS | 1440796-75-7 |
| MW: | 430.97 D |
ab 80,00 €
Anti-Glyt2, clone 29S38
Artikelnummer: NSJ-RQ8847
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA.
| Schlagworte: | Anti-SLC6A5, Anti-Solute carrier family 6 member 5, Anti-Sodium- and chloride-dependent glycine transporter 2, Glyt2 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-Recombinant Glyt2, clone 5B13
Artikelnummer: E-AN301241L.100
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of...
| Schlagworte: | Anti-SLC6A5, Anti-Solute carrier family 6 member 5, Anti-Sodium- and chloride-dependent glycine transporter 2, Recombinant... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Oleoyl-L-carnitine (chloride)
Artikelnummer: Cay39014-10
Oleoyl-L-carnitine is a long-chain acylcarnitine and an inhibitor of glycine transporter 2 (GlyT2, IC50 = 340 nM). It is selective for GlyT2 over GlyT1 (IC50 = >10,000 nM). Plasma levels of oleoyl-L-carnitine are increased in patients with chronic kidney disease or end-stage renal disease receiving incident...
| Schlagworte: | C18:1 Carnitine, CAR 18:1, L-Carnitine oleoyl ester, L-Octadecanoylcarnitine,... |
| Anwendung: | Long-chain acylcarnitine, GlyT2 inhibitor |
| CAS | 31062-78-9 |
| MW: | 462.1 D |
ab 79,00 €
Bitopertin
Artikelnummer: Cay19896-10
Bitopertin is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 0.03 µM). It is selective for GlyT1 over GlyT2 (IC50 = >30 µM) as well as a panel of 107 receptors, transporters, and enzymes at 10 µM. Bitopertin (0.1 µM) increases long-term potentiation in rat hippocampal CA1 slices. It reverses hyperlocomotion...
| Schlagworte: | RG-1678, RO-4917838,... |
| Anwendung: | GlyT1 inhibitor |
| CAS | 845614-11-1 |
| MW: | 543.5 D |
ab 181,00 €
Sarcosine
Artikelnummer: Cay26799-100
Sarcosine is an intermediate in the biosynthesis of glycine from choline. It is a selective inhibitor of glycine transporter 1 (GlyT1) with IC50 values of 91 and greater than 1,000 µM for GlyT1 and GlyT2, respectively, in HEK293 cells expressing the human transporters. Sarcosine levels are increased in prostate...
| Schlagworte: | N-methyl-glycine |
| Anwendung: | Glycine biosynthesis intermediate, GlyT1 inhibitor |
| CAS | 107-97-1 |
| MW: | 89.1 D |
ab 49,00 €
Oleoyl-D-lysine (sodium salt)
Artikelnummer: Cay27862-1
Oleoyl-D-lysine is an inhibitor of glycine transporter 2a (GlyT2a). It selectively inhibits GlyT2a (IC50 = 48.3 nM) over GlyT1b (IC50 = >3,000 nM) in Xenopus oocytes expressing the human transporters. Oleoyl-D-lysine (30 mg/kg, i.p.) reduces allodynia in a nerve ligation rat model of neuropathic pain.Formal Name:...
| Schlagworte: | N2-[(9Z)-1-oxo-9-octadecen-1-yl]-D-lysine, monosodium salt |
| Anwendung: | GlyT2a inhibitor |
| MW: | 433.6 D |
ab 56,00 €
Anti-SLC6A9
Artikelnummer: E-AB-18007.120
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. Protein function: Terminates the action of glycine by its high affinity sodium- dependent...
| Schlagworte: | Anti-GlyT1, Anti-GlyT-1, Anti-SLC6A9, Anti-Solute carrier family 6 member 9, Anti-Sodium- and chloride-dependent glycine... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-SLC6A9
Artikelnummer: E-AB-19917.120
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. Protein function: Terminates the action of glycine by its high affinity sodium- dependent...
| Schlagworte: | Anti-GlyT1, Anti-GlyT-1, Anti-SLC6A9, Anti-Solute carrier family 6 member 9, Anti-Sodium- and chloride-dependent glycine... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
ALX 5407 (hydrochloride)
Artikelnummer: Cay30626-1
ALX 5407 is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 3 nM). It is selective for GlyT1 over GlyT2 (IC50 = >10 µM), as well as over NMDA receptors and the inhibitory glycine receptor at 100 µM. ALX 5407 (10 mg/kg) increases prefrontal cortical levels of glycine in rats. It also reverses MK-801-induced...
| Schlagworte: | (R)-N-(3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)-N-methylglycine, monohydrochloride |
| Anwendung: | GlyT1 inhibitor |
| CAS | 200006-08-2 |
| MW: | 429.9 D |
ab 49,00 €
Anti-SLC6A9
Artikelnummer: ATA-HPA013977.100
Protein function: Terminates the action of glycine by its high affinity sodium- dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as...
| Schlagworte: | Anti-GlyT1, Anti-SLC6A9, Anti-GlyT-1, Anti-Solute carrier family 6 member 9, Anti-Sodium- and chloride-dependent glycine... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
GlyT1 Inhibitor 1
Artikelnummer: TGM-T11435-100mg
Description: GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor [IC50: 38 nM for rGlyT1] exhibiting antipsychotic activity. Target: Others. Smiles: CC(C)Oc1ccc(cc1C(=O)N1Cc2cn(nc2C1)-c1ccnc(C)c1)C#N. References: Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1)...
| Anwendung: | GlyT1 inhibitor |
| CAS | 1820934-93-7 |
| MW: | 387.43 D |
ab 1.327,00 €