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Zu "K05032" wurden 47 Artikel gefunden!
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Artikelnummer: ELK-ELK4729.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ABCC8. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ABCC8. Next,...
Schlagworte: | ABCC8, HRINS, Sulfonylurea receptor 1, ATP-binding cassette sub-family C member 8 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
365,00 €
ab 328,50 €
Artikelnummer: Cay15416-25
Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively. It completely relaxes coronary artery rings preconstricted with serotonin (Cay-14332, IC50 = 1.26 µM)....
Schlagworte: | N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-guanidine, monohydrate |
CAS | 85371-64-8 |
MW: | 263.4 D |
ab 39,00 €
Artikelnummer: Cay23320-250
Nateglinide is a hypoglycemic agent. It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 µM. Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic beta cells, an effect that can be inhibited by the L-type calcium...
Schlagworte: | A-4166, SDZ-DJN 608, N-[[trans-4-(1-methylethyl)cyclohexyl]carbonyl]-D-phenylalanine |
Anwendung: | Sulfonylurea receptor agonist, Hypoglycemic agent |
CAS | 105816-04-4 |
MW: | 317.4 D |
ab 60,00 €
-10 %
Artikelnummer: AG-CR1-3613-G001
White to off-white solid. Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol (gentle warming). Antidiabetic compound, Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1), Causes cell membrane depolarization and opening of...
Schlagworte: | Diabeta, Glibenclamide |
Anwendung: | Antidiabetic compound, SUR1 activator |
CAS | 10238-21-8 |
MW: | 494,0 D |
39,00 €
ab 35,10 €
Artikelnummer: Cay19888-50
Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx...
Schlagworte: | D 860, NSC 23813, NSC 87833, U-2043, N-[(butylamino)carbonyl]-4-methyl-benzenesulfonamide |
Anwendung: | ABCC8 inhibitor |
CAS | 64-77-7 |
MW: | 270.3 D |
ab 46,00 €
Artikelnummer: Cay14576-100
Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells). It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a patch-clamp assay when used at concentrations of 30 and 300 µM. Diazoxide...
Schlagworte: | NSC 64198, NSC 76130, SRG 95213, 7-chloro-3-methyl-1,1-dioxide-2H-1,2,4-benzothiadiazine |
Anwendung: | Potassium channel activator |
CAS | 364-98-7 |
MW: | 230.7 D |
85,00 €
Artikelnummer: Cay23545-5
Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2, IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration...
Schlagworte: | NSC 70762, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-benzenesulfonamide |
Anwendung: | SUR1 inhibitor |
CAS | 1156-19-0 |
MW: | 311.4 D |
ab 92,00 €
Artikelnummer: Cay12090-500
Glimepiride is an inhibitor of sulfonylurea receptors (SURs) linked to the inwardly rectifying potassium channel (Kir6.2, IC50s = 3, 5.4, and 7.3 nM for SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2, respectively, in Xenopus oocytes expressing the mouse receptor). It also induces intracellular insulin receptor (InsR)...
Schlagworte: | HOE 490,... |
Anwendung: | Sulfonylurea receptor 1 agonist, ATP-sensitive potassium (KATP) channel inhibitor |
CAS | 93479-97-1 |
MW: | 490.6 D |
ab 66,00 €
Artikelnummer: LKT-R1860.100
Used in treatment of type II diabetes.
Schlagworte: | Sulfonylurea receptor 1/2 agonist |
Anwendung: | Antidiabetic [oral hypoglycemic agent] |
CAS | 135062-02-1 |
MW: | 452,59 D |
ab 242,00 €
Artikelnummer: Cay25503-1
Gliclazide is a sulfonylurea and an inhibitor of pancreatic beta-cell ATP-sensitive potassium (KATP) channels (IC50 = 184 nM for murine beta-cells). It is selective for pancreatic beta-cell over cardiac and arterial smooth muscle cell KATP channels (IC50s = 19.5 and 37.9 µM, respectively). Gliclazide (5 µM)...
Schlagworte: | N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-benzenesulfonamide |
Anwendung: | Antidiabetic agent, Sulfonamide hypoglycemic, Sulfonylurea receptor agonist |
CAS | 21187-98-4 |
MW: | 323.4 D |
ab 43,00 €
Artikelnummer: ARG22616.50
Protein function: Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. [The UniProt Consortium]
Schlagworte: | Anti-Sur, Anti-Abcc8, Anti-Sulfonylurea receptor 1, Anti-ATP-binding cassette sub-family C member 8 |
Anwendung: | WB |
Wirt: | Mouse |
Spezies-Reaktivität: | rat |
520,00 €
Artikelnummer: ARG64676.100
Protein function: Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. [The UniProt Consortium]
Schlagworte: | Anti-HRINS, Anti-ABCC8, Anti-Sulfonylurea receptor 1, Anti-ATP-binding cassette sub-family C member 8 |
Anwendung: | ELISA, WB |
Wirt: | Goat |
Spezies-Reaktivität: | human |
784,00 €