Zu "K05032" wurden 47 Artikel gefunden!

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Human ABCC8 (ATP Binding Cassette Transporter C8) ELISA Kit
Human ABCC8 (ATP Binding Cassette Transporter C8) ELISA Kit

Artikelnummer: ELK-ELK4729.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ABCC8. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ABCC8. Next,...
Schlagworte: ABCC8, HRINS, Sulfonylurea receptor 1, ATP-binding cassette sub-family C member 8
Anwendung: ELISA
Spezies-Reaktivität: human
365,00 € ab 328,50 €
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Pinacidil (hydrate)
Pinacidil (hydrate)

Artikelnummer: Cay15416-25

Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively. It completely relaxes coronary artery rings preconstricted with serotonin (Cay-14332, IC50 = 1.26 µM)....
Schlagworte: N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-guanidine, monohydrate
CAS 85371-64-8
MW: 263.4 D
ab 39,00 €
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Nateglinide
Nateglinide

Artikelnummer: Cay23320-250

Nateglinide is a hypoglycemic agent. It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 µM. Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic beta cells, an effect that can be inhibited by the L-type calcium...
Schlagworte: A-4166, SDZ-DJN 608, N-[[trans-4-(1-methylethyl)cyclohexyl]carbonyl]-D-phenylalanine
Anwendung: Sulfonylurea receptor agonist, Hypoglycemic agent
CAS 105816-04-4
MW: 317.4 D
ab 60,00 €
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Glyburide
Glyburide

Artikelnummer: AG-CR1-3613-G001

White to off-white solid. Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol (gentle warming). Antidiabetic compound, Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1), Causes cell membrane depolarization and opening of...
Schlagworte: Diabeta, Glibenclamide
Anwendung: Antidiabetic compound, SUR1 activator
CAS 10238-21-8
MW: 494,0 D
39,00 € ab 35,10 €
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Tolbutamide
Tolbutamide

Artikelnummer: Cay19888-50

Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx...
Schlagworte: D 860, NSC 23813, NSC 87833, U-2043, N-[(butylamino)carbonyl]-4-methyl-benzenesulfonamide
Anwendung: ABCC8 inhibitor
CAS 64-77-7
MW: 270.3 D
ab 46,00 €
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Diazoxide
Diazoxide

Artikelnummer: Cay14576-100

Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells). It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a patch-clamp assay when used at concentrations of 30 and 300 µM. Diazoxide...
Schlagworte: NSC 64198, NSC 76130, SRG 95213, 7-chloro-3-methyl-1,1-dioxide-2H-1,2,4-benzothiadiazine
Anwendung: Potassium channel activator
CAS 364-98-7
MW: 230.7 D
85,00 €
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Tolazamide
Tolazamide

Artikelnummer: Cay23545-5

Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2, IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration...
Schlagworte: NSC 70762, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-benzenesulfonamide
Anwendung: SUR1 inhibitor
CAS 1156-19-0
MW: 311.4 D
ab 92,00 €
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Glimepiride
Glimepiride

Artikelnummer: Cay12090-500

Glimepiride is an inhibitor of sulfonylurea receptors (SURs) linked to the inwardly rectifying potassium channel (Kir6.2, IC50s = 3, 5.4, and 7.3 nM for SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2, respectively, in Xenopus oocytes expressing the mouse receptor). It also induces intracellular insulin receptor (InsR)...
Schlagworte: HOE 490,...
Anwendung: Sulfonylurea receptor 1 agonist, ATP-sensitive potassium (KATP) channel inhibitor
CAS 93479-97-1
MW: 490.6 D
ab 66,00 €
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Repaglinide
Repaglinide

Artikelnummer: LKT-R1860.100

Used in treatment of type II diabetes.
Schlagworte: Sulfonylurea receptor 1/2 agonist
Anwendung: Antidiabetic [oral hypoglycemic agent]
CAS 135062-02-1
MW: 452,59 D
ab 242,00 €
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Gliclazide
Gliclazide

Artikelnummer: Cay25503-1

Gliclazide is a sulfonylurea and an inhibitor of pancreatic beta-cell ATP-sensitive potassium (KATP) channels (IC50 = 184 nM for murine beta-cells). It is selective for pancreatic beta-cell over cardiac and arterial smooth muscle cell KATP channels (IC50s = 19.5 and 37.9 µM, respectively). Gliclazide (5 µM)...
Schlagworte: N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-benzenesulfonamide
Anwendung: Antidiabetic agent, Sulfonamide hypoglycemic, Sulfonylurea receptor agonist
CAS 21187-98-4
MW: 323.4 D
ab 43,00 €
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Anti-SUR1 / ABCC8, clone S289-16
Anti-SUR1 / ABCC8, clone S289-16

Artikelnummer: ARG22616.50

Protein function: Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. [The UniProt Consortium]
Schlagworte: Anti-Sur, Anti-Abcc8, Anti-Sulfonylurea receptor 1, Anti-ATP-binding cassette sub-family C member 8
Anwendung: WB
Wirt: Mouse
Spezies-Reaktivität: rat
520,00 €
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Anti-SUR1 / ABCC8, C-terminal
Anti-SUR1 / ABCC8, C-terminal

Artikelnummer: ARG64676.100

Protein function: Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. [The UniProt Consortium]
Schlagworte: Anti-HRINS, Anti-ABCC8, Anti-Sulfonylurea receptor 1, Anti-ATP-binding cassette sub-family C member 8
Anwendung: ELISA, WB
Wirt: Goat
Spezies-Reaktivität: human
784,00 €
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