Zu "K05031" wurden 97 Artikel gefunden!
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Human CFTR (Cystic Fibrosis Transmembrane Conductance...
Artikelnummer: ELK-ELK2973.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CFTR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CFTR. Next,...
| Schlagworte: | CFTR, ABCC7, cAMP-dependent chloride channel, Channel conductance-controlling ATPase, ATP-binding cassette sub-family C... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Ivacaftor
Artikelnummer: Cay15145-5
Ivacaftor is an orally bioavailable potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that improves chloride transport. It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D missense mutation associated with severe cystic fibrosis by...
| Schlagworte: | VX 770, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide |
| Anwendung: | CFTR potentiator |
| CAS | 873054-44-5 |
| MW: | 392.5 D |
ab 44,00 €
Phloxine B
Artikelnummer: Cay18675-10
Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 µg/ml, it can inhibit methicillin-resistant S. aureus growth in vitro....
| Schlagworte: | Acid Red 92, Cyanosine, D&C Red No. 28,... |
| Anwendung: | CFTR modulator, red dye, Gram staining alternative |
| CAS | 18472-87-2 |
| MW: | 829.6 D |
ab 66,00 €
VX-809
Artikelnummer: Cay22196-1
VX-809 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients. It enhances F508del-CFTR protein maturation and restores chloride transport function in FRT cells...
| Schlagworte: | VRT-826809, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]-benzoic acid |
| Anwendung: | CFTR corrector |
| CAS | 936727-05-8 |
| MW: | 452.4 D |
ab 50,00 €
VX-661
Artikelnummer: Cay21480-5
VX-661 is an investigational compound that promotes the maturation of delta F508 mutants of the cystic fibrosis transmembrane conductance regulator (CFTR). Delta F508 CFTR represents a class of CFTR mutation that is characterized by impaired processing of misfolded CFTR proteins and reduced accumulation of the...
| Schlagworte: | Tezacaftor,... |
| Anwendung: | CFTR accumulation stimulator |
| CAS | 1152311-62-0 |
| MW: | 520.5 D |
ab 84,00 €
CFTR Inhibitor-172
Artikelnummer: Cay15545-5
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the...
| Schlagworte: | CFTR(inh)-172, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor 172,... |
| Anwendung: | CFTR blocker |
| CAS | 307510-92-5 |
| MW: | 409.4 D |
ab 109,00 €
CFTR Inhibitor II
Artikelnummer: Cay15772-10
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). This compound binds to a site at the external pore of...
| Schlagworte: | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II, GlyH-101,... |
| Anwendung: | CF transmembrane conductance regulator inhibitor |
| CAS | 328541-79-3 |
| MW: | 493.2 D |
ab 56,00 €
Human CFTR / Cystic fibrosis transmembrane conductance...
Artikelnummer: G-HUFI02312.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Human CFTR (Cystic Fibrosis Transmembrane Conductance...
Artikelnummer: E-EL-H1766.96
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of CFTR in serum, plasma and other biological fluids. Detection Range: 0.16--10ng/mL. Sensitivity: 0.1ng/mL. Protein function: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and...
| Schlagworte: | CFTR, ABCC7, cAMP-dependent chloride channel, Channel conductance-controlling ATPase, ATP-binding cassette sub-family C... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
483,00 €
KM 11060
Artikelnummer: Cay23481-10
KM 11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients. It increases cell surface expression and restores chloride transport function of F508del-CFTRs in...
| Schlagworte: | 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-quinoline |
| Anwendung: | CFTR F508del processing correction |
| CAS | 774549-97-2 |
| MW: | 422.3 D |
ab 121,00 €
PPQ-102
Artikelnummer: Cay16275-10
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). PPQ-102 is a cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels with an IC50 value of 90 nM. At 0.5-5 µM, PPQ-102 has been used to reduce the size...
| Schlagworte: | CFTR Inhibitor IV, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV,... |
| Anwendung: | CFTR inhibitor |
| CAS | 931706-15-9 |
| MW: | 438.5 D |
ab 121,00 €
GLPG1837
Artikelnummer: Cay9003143-1
GLPG1837 is a potentiator of cystic fibrosis transmembrane conductance regulator (CFTR). It increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508 deletion (F508del) and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay. GLPG1837...
| Schlagworte: | ABBV-974, N-[3-(aminocarbonyl)-4,7-dihydro-5,5,7,7-tetramethyl-5H-thieno[2,3-c]pyran-2-yl]-1H-pyrazole-3-carboxamide |
| Anwendung: | CFTR potentiator |
| CAS | 1654725-02-6 |
| MW: | 348.4 D |
ab 60,00 €