Zu "K04954" wurden 19 Artikel gefunden!
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Ivabradine (hydrochloride)
Artikelnummer: Cay15868-10
Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 µM, respectively). In vivo, ivabradine (10 mg/kg per day) reduces...
| Schlagworte: | S 16257,... |
| Anwendung: | If (HCN1 / HCN2 / HCN4) channel blocker |
| CAS | 148849-67-6 |
| MW: | 505.1 D |
ab 98,00 €
Zatebradine (hydrochloride)
Artikelnummer: Cay18608-25
Zatebradine is a bradycardic compound that blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells (IC50s = 1.83, 2.21, 1.9, and 1.88 µM, respectively for HCN1-4 in vitro). Additionally, it can block voltage-gated outward K+ (IK) currents...
| Schlagworte: | UL-FS 49, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,... |
| Anwendung: | HCN channel blocker |
| CAS | 91940-87-3 |
| MW: | 493 D |
ab 142,00 €
Anti-HCN1, clone S70-28
Artikelnummer: ARG22222.50
Protein function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. [The UniProt Consortium]
| Schlagworte: | Anti-Hcn1, Anti-Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| Anwendung: | WB, IHC, ICC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
520,00 €
Anti-HCN1, clone S70-28
Artikelnummer: 200-301-F40
Anti-HCN1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with HCN1 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against HCN2. Cross-reactivity with HCN1 from other sources has not been determined....
| Schlagworte: | Anti-Hcn1, Anti-Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| Anwendung: | IHC, IFM, IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
698,00 €
Anti-HCN1
Artikelnummer: NSJ-R31623
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a...
| Schlagworte: | Anti-HCN1, Anti-BCNG1, Anti-BCNG-1, Anti-Brain cyclic nucleotide-gated channel 1, Anti-Potassium/sodium... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-HCN1
Artikelnummer: E-AB-15708.120
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for...
| Schlagworte: | Anti-HCN1, Anti-BCNG1, Anti-BCNG-1, Anti-Brain cyclic nucleotide-gated channel 1, Anti-Potassium/sodium... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
DK-AH 269
Artikelnummer: Cay21425-10
DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells). DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart. Using telemetric ECG recordings in mice, it reduced heart rate in a...
| Schlagworte: | Cilobradine,... |
| Anwendung: | HCN channel blocker |
| CAS | 186097-54-1 |
| MW: | 519.1 D |
ab 54,00 €
Ivabradine-d3 (hydrochloride)
Artikelnummer: Cay25711-1
Ivabradine-d3 is intended for use as an internal standard for the quantification of ivabradine (Cay-15868) by GC- or LC-MS. Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1,...
| Schlagworte: | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl-d3)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetr... |
| Anwendung: | If (HCN1 / HCN2 / HCN4) channel blocker, GC-MS, LC-MS, internal standard |
| CAS | 1217809-61-4 |
| MW: | 508.1 D |
ab 287,00 €
Anti-HCN1
Artikelnummer: E-AB-66721.120
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for...
| Schlagworte: | Anti-HCN1, Anti-BCNG1, Anti-BCNG-1, Anti-Brain cyclic nucleotide-gated channel 1, Anti-Potassium/sodium... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse, rat |
ab 198,00 €
Anti-HCN1
Artikelnummer: G-CAB2969.100
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 352,00 €
Anti-HCN1
Artikelnummer: G-CAB16198.100
WB 1:500 - 1:2000. Protein function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. [The UniProt Consortium]
| Schlagworte: | Anti-HCN1, Anti-BCNG1, Anti-BCNG-1, Anti-Brain cyclic nucleotide-gated channel 1, Anti-Potassium/sodium... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse, rat |
ab 352,00 €
Anti-HCN1
Artikelnummer: ATA-HPA019195.100
Protein function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH...
| Schlagworte: | Anti-HCN1, Anti-BCNG1, Anti-BCNG-1, Anti-Brain cyclic nucleotide-gated channel 1, Anti-Potassium/sodium... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €