Zu "K04945" wurden 31 Artikel gefunden!
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Anti-KCNN4 / KCa3.1 / SKCa4
Artikelnummer: NSJ-RQ7087
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Intermediate conductance calcium-activated potassium channel protein 1 (KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane...
| Schlagworte: | Anti-IK1, Anti-SK4, Anti-KCa4, Anti-KCNN4, Anti-IKCa1, Anti-SKCa4, Anti-SKCa 4, Anti-KCa3.1, Anti-Putative Gardos channel,... |
| Anwendung: | WB, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
RA-2
Artikelnummer: Cay39567-5
RA-2 is an inhibitor of small-conductance calcium-activated potassium channel 2.3 (KCa2.3/SK3) and intermediate-conductance calcium-activated potassium channel 3.1 (KCa3.1/IK1) (IC50s = 2 and 17 nM, respectively). It is selective for these channels over KCa1.1/BK1, voltage-gated potassium channel 1.2 (Kv1.2), Kv1.3,...
| Schlagworte: | 3-fluoro-4-hydroxy-1,1'-[1,3-phenylenebis(methylene)] ester, benzoic acid |
| Anwendung: | KCa2.3 / KCa3.1 inhibitor |
| CAS | 1867107-62-7 |
| MW: | 414.4 D |
ab 77,00 €
Anti-KCNN4(SK4)
Artikelnummer: ELK-EA302.50
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Protein function: Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization...
| Schlagworte: | Anti-IK1, Anti-SK4, Anti-KCa4, Anti-SKCa4, Anti-KCNN4, Anti-IKCa1, Anti-SKCa 4, Anti-KCa3.1, Anti-Putative Gardos channel,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
169,00 €
TRAM-34
Artikelnummer: Cay23385-5
TRAM-34 is a membrane-permeable inhibitor of the intermediate-conductance calcium-activated potassium channel (IKCa1/KCa3.1). It blocks IKCa1 (Kds = 20 and 25 nM for the cloned and native channel in COS-7 cells and human T lymphocytes, respectively) with 200- to 1,500-fold selectivity for IKCa1 over Kv (Kv1.1-Kv1.5,...
| Schlagworte: | 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole |
| Anwendung: | Membrane-permeable KCNN4 inhibitor |
| CAS | 289905-88-0 |
| MW: | 344.8 D |
ab 50,00 €
Senicapoc
Artikelnummer: Cay29679-50
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (Cay-11016, IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per...
| Schlagworte: | ICA-17043, 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-benzeneacetamide |
| Anwendung: | KCNN4 (IKCa1/KCa3.1) inhibitor |
| CAS | 289656-45-7 |
| MW: | 323.3 D |
ab 43,00 €
NS 309
Artikelnummer: Cay18889-5
NS 309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG, IC50 = 1 µM), but does not, however, affect large...
| Schlagworte: | 6,7-dichloro-1H-indole-2,3-dione 3-oxime |
| Anwendung: | SK/KCa2 & IK/KCa3.1 channel activator |
| CAS | 18711-16-5 |
| MW: | 231 D |
ab 66,00 €
DCEBIO
Artikelnummer: Cay29426-10
DCEBIO is an activator of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels and a dichlorinated derivative of the KCa channel activator 1-EBIO (Cay-14575). It activates IKCa1/KCa3.1 and induces chloride secretion in T84 monolayers in a concentration-dependent manner, an effect that can be...
| Schlagworte: | 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one |
| Anwendung: | IKCa1 / KCa3.1 activator |
| CAS | 60563-36-2 |
| MW: | 231.1 D |
ab 92,00 €
Anti-KCA3.1
Artikelnummer: ABE-39-2053-100
Intermediate conductance calcium-activated potassium channel protein 1(KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of...
| Schlagworte: | Anti-SK4, Anti-IK1, Anti-KCa4, Anti-IKCa1, Anti-KCNN4, Anti-SKCa4, Anti-SKCa 4, Anti-KCa3.1, Anti-Putative Gardos channel,... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
801,00 €
NS 6180
Artikelnummer: Cay14664-10
NS 6180 is an inhibitor of the intermediate-conductance calcium-activated potassium channel 3.1 (IKCa1/KCa3.1, IC50 = 9.4 nM in HEK293 cells expressing the human channel). It inhibits hyperpolarization of human, mouse, and rat erythrocytes induced by the calcium ionophore A23187 (Cay-11016) (IC50s = 14, 15, and 9...
| Schlagworte: | 4-[[3-(trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one |
| Anwendung: | KCa3.1 channel blocker |
| CAS | 353262-04-1 |
| MW: | 323.3 D |
ab 109,00 €
Chlorzoxazone
Artikelnummer: Cay18869-250
Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively). In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the...
| Schlagworte: | NSC 26189, 5-chloro-2(3H)-benzoxazolone |
| Anwendung: | Relaxant (skeletal muscle) |
| CAS | 95-25-0 |
| MW: | 169.6 D |
ab 50,00 €
SKA-121
Artikelnummer: Cay9003088-1
SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3.1) with an EC50 value of 109 nM using whole-cell patch-clamp electrophysiology with calcium in the internal solution. It is selective for KCa3.1 over KCa2.1, KCa2.2 and KCa2.3 (EC50s = 8,700, 6,800,...
| Schlagworte: | 5-methyl-naphth[2,1-d]oxazol-2-amine |
| Anwendung: | KCNN4 / IKCa1 / KCa3.1 modulator |
| CAS | 1820708-73-3 |
| MW: | 198.2 D |
ab 36,00 €
Anti-KCNN4
Artikelnummer: E-AB-13359.120
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated...
| Schlagworte: | Anti-IK1, Anti-SK4, Anti-KCa4, Anti-KCNN4, Anti-IKCa1, Anti-SKCa4, Anti-SKCa 4, Anti-KCa3.1, Anti-Putative Gardos channel,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 71,00 €