Zu "K04943" wurden 20 Artikel gefunden!
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Human KCNN2 (Potassium Intermediate Small Conductance...
Artikelnummer: ELK-ELK6142.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human KCNN2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human KCNN2. Next,...
| Schlagworte: | SK2, SKCa2, KCNN2, KCa2.2, SKCa 2, Small conductance calcium-activated potassium channel protein 2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Anti-KCNN2(SK2)
Artikelnummer: ELK-EA300.50
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Protein function: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:10991935, PubMed:9287325, PubMed:33242881). Activation is followed by...
| Schlagworte: | Anti-SK2, Anti-SKCa2, Anti-KCNN2, Anti-SKCa 2, Anti-KCa2.2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
169,00 €
Chlorzoxazone
Artikelnummer: Cay18869-25
Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively). In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the...
| Schlagworte: | NSC 26189, 5-chloro-2(3H)-benzoxazolone |
| Anwendung: | Relaxant (skeletal muscle) |
| CAS | 95-25-0 |
| MW: | 169.6 D |
ab 50,00 €
NS 8593 (hydrochloride)
Artikelnummer: Cay29774-1
NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (KCa2/SK) channels (Kds = 0.42, 0.6, and 0.73 µM for KCa2.1/SK1, KCa2.2/SK2, and KCa2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for KCa2/SK channels...
| Schlagworte: | N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine, monohydrochloride |
| Anwendung: | Selective KCa2 (SK) channel negative modulator |
| CAS | 875755-24-1 |
| MW: | 299.8 D |
ab 39,00 €
Anti-KCNN2, Internal
Artikelnummer: ARG65085.100
Protein function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. [The UniProt...
| Schlagworte: | Anti-SK2, Anti-SKCa2, Anti-KCNN2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | ELISA, IHC (paraffin), WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
Apamin (trifluoroacetate salt)
Artikelnummer: Cay17082-500
Apamin is an 18-amino acid peptide toxin that has been found in honey bee (A. mellifera) venom. It is an inhibitor of small conductance calcium-activated potassium (KCa2.2/SK2) channels (IC50s = 0.06-0.4 nM). It is selective for KCa2.2/SK2 channels over KCa2.1/SK1 and KCa2.3/SK3 channels (IC50s = 1-12 and 1-13 nM,...
| Schlagworte: | Ro 23-6721,... |
| Anwendung: | Bee venom toxin, KCa2 blocker |
| CAS | 24345-16-2 |
| MW: | 2027.3 D |
214,00 €
Anti-KCNN2
Artikelnummer: NSJ-R34007-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 antibody, KCa2.2 Protein function: Forms a voltage-independent potassium channel activated by...
| Schlagworte: | Anti-SK2, Anti-SKCa2, Anti-KCNN2, Anti-SKCa 2, Anti-KCa2.2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | WB, IHC, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
755,00 €
CyPPA
Artikelnummer: Cay15614-10
CyPPA is a positive modulator of the small-conductance calcium-activated potassium channels KCa2.2/SK2 and KCa2.3/SK3 (EC50s = 14 and 5.6 µM, respectively). It is inactive on both KCa2.1/SK1 and the intermediate conductance calcium-activated potassium channel, KCa3.1/SK4. At KCa2.3/SK3, CyPPA increases the apparent...
| Schlagworte: | N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine |
| Anwendung: | Small conductance calcium-activated channel SK2/SK3 modulator |
| CAS | 73029-73-9 |
| MW: | 285.4 D |
ab 171,00 €
Anti-KCNN2
Artikelnummer: E-AB-18171.120
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels....
| Schlagworte: | Anti-SK2, Anti-KCNN2, Anti-SKCa2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Anti-KCNN2
Artikelnummer: E-AB-52083.120
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels....
| Schlagworte: | Anti-SK2, Anti-KCNN2, Anti-SKCa2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
SKA-31
Artikelnummer: Cay29690-25
SKA-31 is an activator of the small- and intermediate conductance calcium-activated potassium channels KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay). It also blocks the voltage-gated potassium (Kv) channels Kv1.3, Kv1.5, Kv3.1, and Kv3.2 by 10 to 30%...
| Schlagworte: | 2-Aminonaphthiazole, naphtho[1,2-d]thiazol-2-amine |
| Anwendung: | KCa2/3 channel activator |
| CAS | 40172-65-4 |
| MW: | 200.3 D |
ab 72,00 €
Chlorzoxazone-d3
Artikelnummer: Cay34237-1
Chlorzoxazone-d3 is intended for use as an internal standard for the quantification of chlorzoxazone (Cay-18869) by GC- or LC-MS. Chlorzoxazone is a centrally acting muscle relaxant and an activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and...
| Schlagworte: | 5-chloro-2(3H)-benzoxazolone-4,6,7-d3 |
| Anwendung: | GC-MS, LC-MS internal standard, Quantification, Relaxant (skeletal muscle) |
| CAS | 1185173-60-7 |
| MW: | 172.6 D |
ab 193,00 €