Zu "K04943" wurden 27 Artikel gefunden!
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NS8593 hydrochloride
Artikelnummer: TGM-T12256-100mg
Description: NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) . Target: Potassium Channel. Smiles: Cl.C1C[C@@H](Nc2nc3ccccc3[nH]2)c2ccccc2C1. References: Sørensen US, et al. Synthesis and structure-activity relationship studies of...
| Schlagworte: | NS8593 HCl |
| Anwendung: | Selective KCa2 (SK) channel negative modulator |
| CAS | 875755-24-1 |
| MW: | 299.8 D |
ab 40,00 €
Anti-KCNN2
Artikelnummer: CSB-PA285157.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen....
| Schlagworte: | Anti-SK2, Anti-KCNN2, Anti-SKCa2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Small conductance calcium-activated potassium channel...
Artikelnummer: CSB-CF012084RA.100
Organism: Rattus norvegicus (Rat). Source: in vitro E.coli expression system. Expression Region: 1-580aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MSSCRYNGGV MRPLSNLSSS RRNLHEMDSE AQPLQPPASV VGGGGGASSP SAAAAASSSA PEIVVSKPEH NNSNNLALYG TGGGGSTGGG GGGGGGGGGS GHGSSSGTKS...
| Schlagworte: | SK2, SKCa2, Kcnn2, KCa2.2, SKCa 2, Small conductance calcium-activated potassium channel protein 2, Recombinant Rat Small... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | rat |
| MW: | 69.9 kD |
ab 1.458,00 €
Small conductance calcium-activated potassium channel...
Artikelnummer: CSB-EP012084MO1.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-376aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-GFP-tagged. Target Protein Sequence: MPIVLVRPTN RTRRLDSTGA GMGPSSHQQQ ESPLPTITHC AGCTTAWSPC SFNSSDMETP LQFQRGFFPE QPPPPPRSSH LHCQQQQQSQ DKPCAPFAPL PHPHHHPHLA HQQPGSGGSS PCLRCNSCAS...
| Schlagworte: | Sk2, SK2, SKCa2, Kcnn2, KCa2.2, SKCa 2, Small conductance calcium-activated potassium channel protein 2, Recombinant Mouse... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | mouse |
| MW: | 72.6 kD |
ab 364,00 €
Chlorzoxazone
Artikelnummer: Cay18869-25
Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively). In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the...
| Schlagworte: | NSC 26189, 5-chloro-2(3H)-benzoxazolone |
| Anwendung: | Relaxant (skeletal muscle) |
| CAS | 95-25-0 |
| MW: | 169.6 D |
ab 52,00 €
NS 8593 (hydrochloride)
Artikelnummer: Cay29774-1
NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (KCa2/SK) channels (Kds = 0.42, 0.6, and 0.73 µM for KCa2.1/SK1, KCa2.2/SK2, and KCa2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for KCa2/SK channels...
| Schlagworte: | N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine, monohydrochloride |
| Anwendung: | Selective KCa2 (SK) channel negative modulator |
| CAS | 875755-24-1 |
| MW: | 299.8 D |
ab 40,00 €
Anti-KCNN2, Internal
Artikelnummer: ARG65085.100
Protein function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. [The UniProt...
| Schlagworte: | Anti-SK2, Anti-SKCa2, Anti-KCNN2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | ELISA, IHC (paraffin), WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
822,00 €
Apamin (trifluoroacetate salt)
Artikelnummer: Cay17082-500
Apamin is an 18-amino acid peptide toxin that has been found in honey bee (A. mellifera) venom. It is an inhibitor of small conductance calcium-activated potassium (KCa2.2/SK2) channels (IC50s = 0.06-0.4 nM). It is selective for KCa2.2/SK2 channels over KCa2.1/SK1 and KCa2.3/SK3 channels (IC50s = 1-12 and 1-13 nM,...
| Schlagworte: | Ro 23-6721,... |
| Anwendung: | Bee venom toxin, KCa2 blocker |
| CAS | 24345-16-2 |
| MW: | 2027.3 D |
219,00 €
Anti-KCNN2
Artikelnummer: NSJ-R34007-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 antibody, KCa2.2 Protein function: Forms a voltage-independent potassium channel activated by...
| Schlagworte: | Anti-SK2, Anti-SKCa2, Anti-KCNN2, Anti-SKCa 2, Anti-KCa2.2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | WB, IHC, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
790,00 €
CyPPA
Artikelnummer: Cay15614-10
CyPPA is a positive modulator of the small-conductance calcium-activated potassium channels KCa2.2/SK2 and KCa2.3/SK3 (EC50s = 14 and 5.6 µM, respectively). It is inactive on both KCa2.1/SK1 and the intermediate conductance calcium-activated potassium channel, KCa3.1/SK4. At KCa2.3/SK3, CyPPA increases the apparent...
| Schlagworte: | N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine |
| Anwendung: | Small conductance calcium-activated channel SK2/SK3 modulator |
| CAS | 73029-73-9 |
| MW: | 285.4 D |
ab 174,00 €
Anti-KCNN2
Artikelnummer: E-AB-18171.120
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels....
| Schlagworte: | Anti-SK2, Anti-KCNN2, Anti-SKCa2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-KCNN2
Artikelnummer: E-AB-52083.120
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels....
| Schlagworte: | Anti-SK2, Anti-KCNN2, Anti-SKCa2, Anti-KCa2.2, Anti-SKCa 2, Anti-Small conductance calcium-activated potassium channel... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €