Zu "K04905" wurden 38 Artikel gefunden!
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Anti-KCNH2 / ERG-1
Artikelnummer: NSJ-RQ5306
0.5mg/ml if reconstituted with 0.2ml sterile DI water. KCNH2, also known as HERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current...
| Schlagworte: | Anti-KCNH2, Anti-Eag homolog, Anti-Voltage-gated potassium channel subunit Kv11.1, Anti-Ether-a-go-go-related gene... |
| Anwendung: | WB, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Amiodarone (hydrochloride)
Artikelnummer: Cay15213-500
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1...
| Schlagworte: | (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride |
| Anwendung: | Ion channel blocker |
| CAS | 19774-82-4 |
| MW: | 681.8 D |
ab 49,00 €
E-4031 (hydrochloride)
Artikelnummer: Cay15203-5
Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs...
| Schlagworte: | N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-methanesulfonamide, dihydrochloride |
| Anwendung: | ERG K+ channel blocking |
| CAS | 113559-13-0 |
| MW: | 474.4 D |
ab 122,00 €
Dofetilide
Artikelnummer: Cay15045-5
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity,...
| Schlagworte: | Tikosyn, UK 68789, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide |
| Anwendung: | Voltage-gated potassium channel (KCNH2) blocker |
| CAS | 115256-11-6 |
| MW: | 441.6 D |
ab 68,00 €
Dofetilide-d4
Artikelnummer: Cay26451-1
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Cay-15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed...
| Schlagworte: | N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, voltage-gated potassium channel (KCNH2) blocker |
| CAS | 1189700-56-8 |
| MW: | 445.6 D |
ab 228,00 €
hERG (Kv11.1) - HEK293 Recombinant Cell line
Artikelnummer: BPS-60619
Human ERG channel has been stably expressed in HEK293 cell line and its expression was confirmed by Western blotting. The channel activity of hERG was characterized by a fluorescence-based assay using thallium influx as a surrogate indicator of potassium ion channel activity coupled with a thallium-sensitive...
| Schlagworte: | KCNH2, Voltage-gated inwardly rectifying potassium channel KCNH2, Eag homolog, Ether-a-go-go-related gene potassium... |
| Anwendung: | Ion channel expression |
| Wirt: | Human cells |
| Spezies-Reaktivität: | human |
3.472,00 €
NS 1643
Artikelnummer: Cay20343-10
NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 µM). It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1. NS 1643 is commonly used in cells or isolated tissues.Formal Name:...
| Schlagworte: | N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-urea |
| Anwendung: | KCNH2 activator |
| CAS | 448895-37-2 |
| MW: | 380.2 D |
ab 67,00 €
Dofetilide
Artikelnummer: TGM-T6476-100mg
Description: Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and...
| Schlagworte: | UK 68789, UK-68798, Tikosyn |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 115256-11-6 |
| MW: | 441.56 D |
ab 48,00 €
Sotalol HCl
Artikelnummer: LKT-S5976.25
Is a hypertension and cardiac arrhythmias. Inhibits the potassium channels in the heart. The L-form of this compound is also a beta blocker.
| Schlagworte: | Sotalol (hydrochloride) |
| CAS | 959-24-0 |
| MW: | 308,82 D |
ab 157,00 €
Cyclovirobuxine D
Artikelnummer: Cay22260-10
Cyclovirobuxine D (CVB-D) is an alkaloid, and the main active component of the traditional Chinese medicine B. microphylla, that has diverse biological activities. It is an ether-a-go-go related gene (ERG) potassium channel blocker with an IC50 value of 19.7 µM using whole-cell patch-clamp electrophysiology in...
| Schlagworte: | CVB-D, NSC 91722, (3beta,5alpha,16alpha,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol |
| Anwendung: | KCNH2 blocker |
| CAS | 860-79-7 |
| MW: | 402.7 D |
ab 60,00 €
(±)-Ibutilide (hemifumarate)
Artikelnummer: Cay15011-100
(±)-Ibutilide is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM. (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular...
| Schlagworte: | U-70226E, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1) |
| Anwendung: | Potassium channel blocker |
| CAS | 122647-32-9 |
| MW: | 442.6 D |
ab 127,00 €
Nifekalant (hydrochloride)
Artikelnummer: Cay20997-1
Nifekalant is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed rectifier potassium channel (IKr, IC50 = 10 µM) and prolongs cardiac action potential duration (APD) in isolated dog Purkinje fibers when used at concentrations of 1 and 3 µg/ml. Nifekalant (3 mg/kg) inhibits arrhythmias...
| Schlagworte: | 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, monohydrochloride |
| Anwendung: | Ikr blocker |
| CAS | 130656-51-8 |
| MW: | 441.9 D |
ab 49,00 €