Zu "K04905" wurden 29 Artikel gefunden!
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Anti-KCNH2 / ERG-1
Artikelnummer: NSJ-RQ7086
0.5mg/ml if reconstituted with 0.2ml sterile DI water. KCNH2, also known as ERG-1, H-ERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier...
| Schlagworte: | Anti-ERG, Anti-KCNH2, Anti-H-ERG, Anti-hERG1, Anti-ERG-1, Anti-hERG-1, Anti-Eag homolog, Anti-Eag-related protein 1,... |
| Anwendung: | WB, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
SLU-10482
Artikelnummer: Cay39375-1
SLU-10482 is an antiparasitic agent. It reduces the number of C. parvum parasites in HCT-8 cells (EC50 = 0.07 µM). SLU-10482 binds to human ether-a-go-go (hERG, Kd = 43 µM) to a lesser extent than the antiparasitic SLU-2633. In vivo, SLU-10482 (5 and 15 mg/kg twice per day) decreases the number of fecal oocysts in a...
| Schlagworte: | 2-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[4-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1-piperazinyl]-ethanone |
| Anwendung: | Antiparasitic agent |
| CAS | 2755451-45-5 |
| MW: | 408.4 D |
ab 35,00 €
Amiodarone (hydrochloride)
Artikelnummer: Cay15213-500
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1...
| Schlagworte: | (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride |
| Anwendung: | Ion channel blocker |
| CAS | 19774-82-4 |
| MW: | 681.8 D |
ab 43,00 €
E-4031 (hydrochloride)
Artikelnummer: Cay15203-5
Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs...
| Schlagworte: | N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-methanesulfonamide, dihydrochloride |
| Anwendung: | ERG K+ channel blocking |
| CAS | 113559-13-0 |
| MW: | 474.4 D |
ab 109,00 €
Dofetilide-d4
Artikelnummer: Cay26451-1
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Cay-15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed...
| Schlagworte: | N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide |
| Anwendung: | GC-MS, LC-MS, Quantification, Internal standard, Voltage-gated potassium channel (KCNH2) blocker |
| CAS | 1189700-56-8 |
| MW: | 445.6 D |
ab 205,00 €
hERG (Kv11.1) - HEK293 Recombinant Cell line
Artikelnummer: BPS-60619
Human ERG channel has been stably expressed in HEK293 cell line and its expression was confirmed by Western blotting. The channel activity of hERG was characterized by a fluorescence-based assay using thallium influx as a surrogate indicator of potassium ion channel activity coupled with a thallium-sensitive...
| Schlagworte: | ERG, H-ERG, hERG1, KCNH2, ERG-1, hERG-1, Eag homolog, Eag-related protein 1, Ether-a-go-go-related protein 1,... |
| Spezies-Reaktivität: | human |
2.609,00 €
Dofetilide
Artikelnummer: Cay15045-10
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity,...
| Schlagworte: | Tikosyn, UK 68789, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide |
| Anwendung: | Voltage-gated potassium channel (KCNH2) blocker |
| CAS | 115256-11-6 |
| MW: | 441.6 D |
ab 84,00 €
NS 1643
Artikelnummer: Cay20343-10
NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 µM). It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1. NS 1643 is commonly used in cells or isolated tissues.Formal Name:...
| Schlagworte: | N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-urea |
| Anwendung: | KCNH2 activator |
| CAS | 448895-37-2 |
| MW: | 380.2 D |
ab 60,00 €
Sotalol HCl
Artikelnummer: LKT-S5976.25
Is a hypertension and cardiac arrhythmias. Inhibits the potassium channels in the heart. The L-form of this compound is also a beta blocker.
| Schlagworte: | Sotalol (hydrochloride) |
| CAS | 959-24-0 |
| MW: | 308,82 D |
ab 149,00 €
Cyclovirobuxine D
Artikelnummer: Cay22260-10
Cyclovirobuxine D (CVB-D) is an alkaloid, and the main active component of the traditional Chinese medicine B. microphylla, that has diverse biological activities. It is an ether-a-go-go related gene (ERG) potassium channel blocker with an IC50 value of 19.7 µM using whole-cell patch-clamp electrophysiology in...
| Schlagworte: | CVB-D, NSC 91722, (3beta,5alpha,16alpha,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol |
| Anwendung: | KCNH2 blocker |
| CAS | 860-79-7 |
| MW: | 402.7 D |
ab 54,00 €
(±)-Ibutilide (hemifumarate)
Artikelnummer: Cay15011-100
(±)-Ibutilide is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM. (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular...
| Schlagworte: | U-70226E, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1) |
| Anwendung: | Potassium channel blocker |
| CAS | 122647-32-9 |
| MW: | 442.6 D |
ab 114,00 €
Nifekalant (hydrochloride)
Artikelnummer: Cay20997-1
Nifekalant is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed rectifier potassium channel (IKr, IC50 = 10 µM) and prolongs cardiac action potential duration (APD) in isolated dog Purkinje fibers when used at concentrations of 1 and 3 µg/ml. Nifekalant (3 mg/kg) inhibits arrhythmias...
| Schlagworte: | 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, monohydrochloride |
| Anwendung: | Ikr blocker |
| CAS | 130656-51-8 |
| MW: | 441.9 D |
ab 43,00 €