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Zu "K04857" wurden 25 Artikel gefunden!
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Artikelnummer: ELK-ELK6870.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CACNa1S. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CACNa1S....
Schlagworte: | DHPR, Cach1, Cacna1s, Dihydropyridine receptor, Voltage-gated calcium channel subunit alpha Cav1.1, Voltage-dependent... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: Cay11106-5
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 µM. Nifedipine (1 µM) reduces TGF-beta-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse...
Schlagworte: | BAY 1040, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester |
Anwendung: | Dihydropyridine calcium channel blocker |
CAS | 21829-25-4 |
MW: | 346.3 D |
ab 27,00 €
Artikelnummer: Cay19645-5
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle. It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents. For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4)...
Schlagworte: | beta-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride |
Anwendung: | Calcium channel blocker |
CAS | 68099-86-5 |
MW: | 403 D |
ab 43,00 €
Artikelnummer: Cay21607-50
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in...
Schlagworte: | (±)-Benidipine, KW-3049, (4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl... |
Anwendung: | Calcium channel blocker |
CAS | 91599-74-5 |
MW: | 542 D |
ab 50,00 €
Artikelnummer: LKT-A5045.1
Almost white crystalline powder. A calcium channel antagonist with potent antioxidant activity. It inhibits doxorubicin-induced myocyte apoptosis by supressing the mitochondrial apoptotic pathway.It has been found to inhibit hyperplasia and hypertrophy in mesangial cells.
Schlagworte: | UK-48340 |
Anwendung: | Ca channel antagonist |
CAS | 88150-42-9 |
MW: | 408,88 D |
ab 135,00 €
Artikelnummer: Cay29104-50
Lercanidipine is a dihydropyridine L-type calcium channel blocker. It binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM). Lercanidipine reduces diastolic blood pressure...
Schlagworte: | 3,5-pyridinedicarboxylic acid,... |
Anwendung: | L-type calcium channel blocker |
CAS | 132866-11-6 |
MW: | 648.2 D |
ab 52,00 €
Artikelnummer: Cay21243-5
Nilvadipine is a dihydropyridine L-type calcium channel blocker. It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 µM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in...
Schlagworte: | (±)-Nilvadipine, CL 287,389, FK-235, FR34235, SKF 102362,... |
Anwendung: | Calcium channel L-type blocker |
CAS | 75530-68-6 |
MW: | 385.4 D |
ab 43,00 €
Artikelnummer: Cay21689-50
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel alpha1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons....
Schlagworte: | 1,4-dihydro-2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester |
Anwendung: | Cell-permeable L-type calcium channel protein inhibitor |
CAS | 54280-71-6 |
MW: | 419.3 D |
ab 92,00 €
Artikelnummer: Cay23025-50
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes). It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively). Clevidipine...
Schlagworte: | rac-Clevidipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl... |
Anwendung: | L-type calcium channel blocker |
CAS | 167221-71-8 |
MW: | 456.3 D |
ab 109,00 €
Artikelnummer: Cay28270-500
Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6,...
Schlagworte: | GR 43659X, GX 1048,... |
Anwendung: | L-type calcium channel blocker |
CAS | 103890-78-4 |
MW: | 455.5 D |
ab 130,00 €
Artikelnummer: Cay28732-5
Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker. It blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 µg/ml, respectively). It also inhibits calcium influx stimulated by the acetylcholine receptor agonist carbachol (carbamoylcholine,...
Schlagworte: | CAI, L-651,582, NSC 609974, 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide |
Anwendung: | Non-selective calcium channel blocker |
CAS | 99519-84-3 |
MW: | 424.7 D |
ab 142,00 €
COVID-19 Forschung
Artikelnummer: Cay33114-5
Efonidipine is an inhibitor of L- and T-type voltage-gated calcium channels (Cavs). It inhibits Cav1.2a (IC50 = 1.8 nM for the hamster channel), an L-type Cav, and Cav3.2 (IC50 = 350 nM for the human channel), a T-type Cav. It also inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in...
Schlagworte: | (±)-Efonidipine,... |
Anwendung: | L-type / T-type calcium channel inhibitor |
CAS | 111011-63-3 |
MW: | 631.7 D |
ab 92,00 €