Zu "K04849" wurden 34 Artikel gefunden!
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(S)-(-)-BAY-K-8644
Artikelnummer: Cay19988-1
(S)-(-)-BAY-K-8644 is an activator of voltage-sensitive L-type calcium channels. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. When combined with BIX01294 (Cay-13124), (S)-(-)-BAY-K-8644 can enable reprogramming of mouse...
| Schlagworte: | (4S)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester |
| Anwendung: | Voltage-sensitive L-type calcium channel activator |
| CAS | 98625-26-4 |
| MW: | 356.3 D |
ab 49,00 €
Cilnidipine
Artikelnummer: Cay26080-1
Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 µM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in...
| Schlagworte: | FRC 8653, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl)... |
| Anwendung: | Calcium channel L type blocker, calcium channel N type blocker |
| CAS | 132203-70-4 |
| MW: | 492.5 D |
ab 102,00 €
(S)-(-)-Bay-K-8644
Artikelnummer: TGM-TQ0144-1mg
Description: (S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) is an agonist of L-type Ca2+ channels, activating Ba2+ currents with an EC50 of 32 nM. Target: Calcium Channel. Smiles: COC(=O)C1=C(C)NC(C)=C([C@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O. References: Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic...
| Schlagworte: | (S)-(-)-Bay K 8644 |
| Anwendung: | Voltage-sensitive L-type calcium channel activator |
| CAS | 98625-26-4 |
| MW: | 356.3 D |
ab 62,00 €
GV-58
Artikelnummer: AG-MR-C0035-M001
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.
| Schlagworte: | (2R)-2-[(6-{[(5-Methylthiophen-2-yl)methyl]amino}-9-propyl-9H-purin-2-yl)amino]butan-1-ol, Rx-ID: 23159892 |
| Anwendung: | N- and P/Q-type Ca2+-channel agonist |
| MW: | 374,5 D |
ab 72,00 €
Ziconotide (trifluoroacetate salt)
Artikelnummer: Cay23913-1
Ziconotide is a synthetic version of omega-conopeptide MVIIA, a peptide toxin originally found in the venom of the fish-eating marine snail C. magus, that blocks N-type calcium channels in rat brain membranes (Kds = 1.1-18 pM, IC50s = 2-55 pM)., It blocks high-voltage-activated calcium currents in rat superior...
| Schlagworte: | SNX-111, omega-Conotoxin MVIIA,... |
| Anwendung: | Analgesic, antiinflammatory, neuroprotectant, calcium channel blocker |
| CAS | 1660960-77-9 |
| MW: | 2639.1 D |
ab 379,00 €
PD 173212
Artikelnummer: Cay29447-1
PD 173212 is an N-type calcium channel blocker (IC50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg.Formal Name: N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-L-tyrosinamide. CAS Number: 217171-01-2. Molecular Formula:...
| Schlagworte: | N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-L-tyrosinamide |
| Anwendung: | N-type calcium channel blocker |
| CAS | 217171-01-2 |
| MW: | 599.9 D |
ab 50,00 €
Cilnidipine-d7
Artikelnummer: Cay33796-1
Cilnidipine-d7 is intended for use as an internal standard for the quantification of cilnidipine (Cay-26080) by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a...
| Schlagworte: | 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl-d7)... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, calcium channel blocker |
| MW: | 499.6 D |
946,00 €
Anti-CACNA1B
Artikelnummer: ATA-HPA044347.100
Protein function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The...
| Schlagworte: | Anti-BIII, Anti-CACH5, Anti-CACNA1B, Anti-Brain calcium channel III, Anti-Voltage-gated calcium channel subunit alpha... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €
Myr-Tat-CBD3 (trifluoroacetate salt)
Artikelnummer: Cay37465-1
Myr-Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). It inhibits the Cav2.2-CRMP2 interaction by approximately 81% when used at a concentration of 10 µM and inhibits potassium-induced calcium influx...
| Schlagworte: | Myr-Tat-Calcium Channel-binding Domain 3, N-myristate-Tat-CBD3,... |
| Anwendung: | Cav2.2-CRMP2 protein-protein interaction inhibitor |
| MW: | 3403.1 D |
ab 40,00 €
Tat-CBD3 (trifluoroacetate salt)
Artikelnummer: Cay37448-1
Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). It also inhibits the protein-protein interaction between CRMP2 and the NMDA receptor NR2B subunit. Tat-CBD3 (10 µM) inhibits the Cav2.2-CRMP2...
| Anwendung: | Cav2.2-CRMP2 (CACNA1B-DPYSL2) protein-protein interaction inhibitor |
| MW: | 3192.7 D |
ab 42,00 €
Tat-CBD3A6K (trifluoroacetate salt)
Artikelnummer: Cay37449-1
Tat-CBD3A6K is a peptide and derivative of the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2) protein-protein interaction inhibitor Tat-CBD3 (Cay-37448). Tat-CBD3A6K (10 mg/kg) prevents decreases in the paw withdrawal threshold in a rat model of antiretroviral...
| Schlagworte: | L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-alanyl-L-arginy... |
| Anwendung: | Cav2.2-CRMP2 (CACNA1B-DPYSL2) protein-protein interaction inhibitor |
| MW: | 3249.8 D |
ab 40,00 €
Mouse CACNa1B (Calcium Channel, Voltage Dependent,...
Artikelnummer: ELK-ELK6874.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CACNa1B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CACNa1B....
| Schlagworte: | BIII, Cach5, Cacna1b, Brain calcium channel III, Voltage-gated calcium channel subunit alpha Cav2.2, Calcium channel, L... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 374,00 €