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Zu "K04842" wurden 22 Artikel gefunden!
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Artikelnummer: Cay38335-1
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol (Cay-19377) by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the rat channel). Ambroxol...
Schlagworte: | trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol-d5, monohydrochloride |
Anwendung: | GC-MS, LC-MS, internal standard, quantification, sodium channel blocker |
CAS | 2741380-71-0 |
MW: | 419.6 D |
ab 104,00 €
Artikelnummer: Cay10012588-100
Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for...
Schlagworte: | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide |
Anwendung: | Nav1.8 sodium channel inhibitor |
CAS | 944261-79-4 |
MW: | 357.8 D |
ab 50,00 €
Artikelnummer: Cay15428-25
Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
Schlagworte: | BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
Anwendung: | Voltage-gated sodium channel inhibitor |
CAS | 84057-84-1 |
MW: | 256.1 D |
ab 77,00 €
Artikelnummer: Cay19377-25
Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM). It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the...
Schlagworte: | NA 872, trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol, monohydrochloride |
Anwendung: | Sodium channel blocker |
CAS | 23828-92-4 |
MW: | 414.6 D |
ab 50,00 €
Artikelnummer: Cay26495-1
(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...
Schlagworte: | (S)-Ropivacaine-d7, (S)-N-(2,6-dimethylphenyl)-1-(propyl-d7)piperidine-2-carboxamide, monohydrochloride |
Anwendung: | GC-MS, LC-MS, Quantification, Internal standard, Sodium channel blocker |
CAS | 1217667-10-1 |
MW: | 317.9 D |
ab 139,00 €
Artikelnummer: ARG56141.50
Protein function: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in...
Schlagworte: | Anti-Sns, Anti-PN3, Anti-Scn10a, Anti-Sensory neuron sodium channel, Anti-Peripheral nerve sodium channel 3, Anti-Sodium... |
Anwendung: | ICC, IF, IHC (paraffin), WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
628,00 €
Artikelnummer: BPS-60521
Stable recombinant HEK293 cell line expressing tetracycline-inducible human Nav1.8 (Genbank #NP_006505.2) fused to Green Fluorescent Protein (GFP) [Ex. ~395 nm, 475 nm, em ~510 nm] and the human sodium channel beta2 subunit (Genbank #NM_004588, SCN2B). Nav1.8 is also known as tetrodotoxin-resistant voltage-gated...
Schlagworte: | PN3, hPN3, SCN10A, Peripheral nerve sodium channel 3, Sodium channel protein type X subunit alpha, Sodium channel protein... |
Anwendung: | Drug compound screening, FC, antigen |
Wirt: | human cells |
Spezies-Reaktivität: | human |
11.769,00 €
Artikelnummer: 200-301-G22
Anti-NAV1.8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.8 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross reactivity against other Nav channels. Cross-reactivity with NAV1.8 from other sources has not been...
Schlagworte: | Anti-Sns, Anti-PN3, Anti-Scn10a, Anti-Sensory neuron sodium channel, Anti-Peripheral nerve sodium channel 3, Anti-Sodium... |
Anwendung: | IHC, IFM, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, rat |
698,00 €
Artikelnummer: Cay22111-1
PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 µM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 µM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 µM)....
Schlagworte: | 6-amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-pyridinecarboxamide |
Anwendung: | NaV1.8 channel blocker |
CAS | 875051-72-2 |
MW: | 330.6 D |
ab 44,00 €
Artikelnummer: Cay23490-10
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...
Schlagworte: | GSK1014802A, (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride |
Anwendung: | Voltage-gated sodium channel inhibitor |
CAS | 934240-31-0 |
MW: | 350.8 D |
ab 50,00 €
Artikelnummer: E-AB-12862.120
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral...
Schlagworte: | Anti-PN3, Anti-hPN3, Anti-SCN10A, Anti-Peripheral nerve sodium channel 3, Anti-Sodium channel protein type X subunit... |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 71,00 €
Artikelnummer: Cay16618-1
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 µM) blocks...
Schlagworte: | 1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide |
Anwendung: | Sodium influx blocker |
CAS | 38396-39-3 |
MW: | 288.4 D |
ab 43,00 €