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Zu "K04838" wurden 15 Artikel gefunden!
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Artikelnummer: Cay15428-100
Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
Schlagworte: | BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
Anwendung: | Voltage-gated sodium channel inhibitor |
CAS | 84057-84-1 |
MW: | 256.1 D |
ab 77,00 €
Artikelnummer: E-AB-12860.120
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type V subunit alpha, Anti-Sodium channel protein type 5 subunit alpha,... |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Artikelnummer: LKT-B6918.5
Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening effect, this activity results in...
Schlagworte: | PbTx-3 |
Anwendung: | SCN4A/Nav1.4 / SCN5A/Nav1.5 agonist |
CAS | 85079-48-7 |
MW: | 897.2 D |
ab 862,00 €
Artikelnummer: Cay26078-500
Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro. Tolperisone acts as an antispastic agent that attenuates monosynaptic,...
Schlagworte: | N-553, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride |
Anwendung: | Voltage-gated sodium channel inhibitor, muscle relaxant |
CAS | 3644-61-9 |
MW: | 281.8 D |
ab 245,00 €
Artikelnummer: G-CAB16665.100
WB 1:500 - 1:2000. Protein function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in...
Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type V subunit alpha, Anti-Sodium channel protein type 5 subunit alpha,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | mouse |
ab 352,00 €
Artikelnummer: Cay37196-5
Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Cay-15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM,...
Schlagworte: | LTG-d3, 6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine |
Anwendung: | GC-MS, LC-MS internal standard, quantification, oltage-gated sodium channel inhibitor |
CAS | 1132746-94-1 |
MW: | 259.1 D |
ab 225,00 €
Artikelnummer: LKT-C0270.1
Cytochrome P450 3A4 inducing anti-epileptic drug. It Increases metabolism of CPT11 and Paclitaxel, and many tyrosine kinase inhibitors. Used in the treatment of shooting neuralgic pain attacks.
Anwendung: | Voltage-gated sodium channel (SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A) blocker |
CAS | 298-46-4 |
MW: | 236.27 D |
ab 55,00 €
Artikelnummer: 041466-APC.200
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
Anwendung: | FLISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
993,00 €
Artikelnummer: 041466-Biotin.200
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
Anwendung: | ELISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
993,00 €
Artikelnummer: 041466-FITC.200
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
Anwendung: | FLISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
993,00 €
Artikelnummer: 041466.200
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
Anwendung: | ELISA, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
728,00 €
Artikelnummer: N0530-18.50
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of...
Schlagworte: | Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha, Anti-Voltage-gated... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | mouse, rat |
780,00 €