Zu "K04838" wurden 15 Artikel gefunden!

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Lamotrigine
Lamotrigine

Artikelnummer: Cay15428-100

Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
Schlagworte: BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Anwendung: Voltage-gated sodium channel inhibitor
CAS 84057-84-1
MW: 256.1 D
ab 77,00 €
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Anti-SCN5A
Anti-SCN5A

Artikelnummer: E-AB-12860.120

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type V subunit alpha, Anti-Sodium channel protein type 5 subunit alpha,...
Anwendung: IHC, ELISA
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
ab 71,00 €
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Brevetoxin 3
Brevetoxin 3

Artikelnummer: LKT-B6918.5

Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening effect, this activity results in...
Schlagworte: PbTx-3
Anwendung: SCN4A/Nav1.4 / SCN5A/Nav1.5 agonist
CAS 85079-48-7
MW: 897.2 D
ab 862,00 €
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Tolperisone (hydrochloride)
Tolperisone (hydrochloride)

Artikelnummer: Cay26078-500

Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro. Tolperisone acts as an antispastic agent that attenuates monosynaptic,...
Schlagworte: N-553, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride
Anwendung: Voltage-gated sodium channel inhibitor, muscle relaxant
CAS 3644-61-9
MW: 281.8 D
ab 245,00 €
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Anti-SCN5A
Anti-SCN5A

Artikelnummer: G-CAB16665.100

WB 1:500 - 1:2000. Protein function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in...
Schlagworte: Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type V subunit alpha, Anti-Sodium channel protein type 5 subunit alpha,...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: mouse
ab 352,00 €
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Lamotrigine-d3
Lamotrigine-d3

Artikelnummer: Cay37196-5

Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Cay-15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM,...
Schlagworte: LTG-d3, 6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine
Anwendung: GC-MS, LC-MS internal standard, quantification, oltage-gated sodium channel inhibitor
CAS 1132746-94-1
MW: 259.1 D
ab 225,00 €
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Carbamazepine
Carbamazepine

Artikelnummer: LKT-C0270.1

Cytochrome P450 3A4 inducing anti-epileptic drug. It Increases metabolism of CPT11 and Paclitaxel, and many tyrosine kinase inhibitors. Used in the treatment of shooting neuralgic pain attacks.
Anwendung: Voltage-gated sodium channel (SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A) blocker
CAS 298-46-4
MW: 236.27 D
ab 55,00 €
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Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein card
Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5...

Artikelnummer: 041466-APC.200

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,...
Anwendung: FLISA, WB
Wirt: Rabbit
Spezies-Reaktivität: human
993,00 €
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Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein card
Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5...

Artikelnummer: 041466-Biotin.200

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,...
Anwendung: ELISA, WB
Wirt: Rabbit
Spezies-Reaktivität: human
993,00 €
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Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein card
Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5...

Artikelnummer: 041466-FITC.200

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,...
Anwendung: FLISA, WB
Wirt: Rabbit
Spezies-Reaktivität: human
993,00 €
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Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein card
Anti-SCN5A, NT (SCN5A, Sodium channel protein type 5...

Artikelnummer: 041466.200

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
Schlagworte: Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,...
Anwendung: ELISA, WB
Wirt: Rabbit
Spezies-Reaktivität: human
728,00 €
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Anti-NaV1.5 (SKM2, Scn5a)
Anti-NaV1.5 (SKM2, Scn5a)

Artikelnummer: N0530-18.50

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of...
Schlagworte: Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha, Anti-Voltage-gated...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: mouse, rat
780,00 €
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