Zu "K04838" wurden 21 Artikel gefunden!
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Moricizine (hydrochloride)
Artikelnummer: Cay45203-10
A class I antiarrhythmic agent, induces both tonic and phasic blocks of sodium currents in isolated guinea pig atrial myocytes at 30 µM, induces a tonic block of sodium currents in isolated guinea pig ventricular myocytes at 1 and 10 µM, reduces spontaneous arrhythmias occurring 24 hours after LAD coronary artery...
| Schlagworte: | EN-313, Moracizine, N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-carbamic acid, ethyl ester,... |
| Anwendung: | Class I antiarrhythmic agent |
| CAS | 29560-58-5 |
| MW: | 463.98 D |
ab 75,00 €
Carbamazepine
Artikelnummer: LKT-C0270.1
Cytochrome P450 3A4 inducing anti-epileptic drug. It Increases metabolism of CPT11 and Paclitaxel, and many tyrosine kinase inhibitors. Used in the treatment of shooting neuralgic pain attacks.
| Anwendung: | Voltage-gated sodium channel (SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A) blocker |
| CAS | 298-46-4 |
| MW: | 236.27 D |
ab 58,00 €
Lamotrigine
Artikelnummer: Cay15428-100
Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
| Schlagworte: | BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 84057-84-1 |
| MW: | 256.1 D |
ab 85,00 €
Anti-SCN5A
Artikelnummer: E-AB-12860.120
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT...
| Schlagworte: | Anti-HH1, Anti-SCN5A, Anti-Sodium channel protein type V subunit alpha, Anti-Sodium channel protein type 5 subunit alpha,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Tolperisone (hydrochloride)
Artikelnummer: Cay26078-500
Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro. Tolperisone acts as an antispastic agent that attenuates monosynaptic,...
| Schlagworte: | N-553, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride |
| Anwendung: | Voltage-gated sodium channel inhibitor, muscle relaxant |
| CAS | 3644-61-9 |
| MW: | 281.8 D |
ab 69,00 €
Anti-SCN5A
Artikelnummer: CSB-PA280563.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-hH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
284,00 €
Anti-SCN5A
Artikelnummer: CSB-PA988378.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SCN5A. Antigen Species: Human
| Schlagworte: | Anti-hH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-SCN5A
Artikelnummer: CSB-PA943613.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SCN5A. Antigen Species: Human
| Schlagworte: | Anti-hH1, Anti-SCN5A, Anti-Sodium channel protein type 5 subunit alpha, Anti-Sodium channel protein type V subunit alpha,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Vernakalant Hydrochloride
Artikelnummer: TGM-T17227-100mg
Description: Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. Target: Sodium Channel, Potassium Channel. Smiles: Cl.COc1ccc(CCO[C@@H]2CCCC[C@H]2N2CC[C@@H](O)C2)cc1OC. References: Eldstrom J, et al. The molecular basis of...
| Schlagworte: | RSD1235 hydrochloride |
| Anwendung: | Targets potassium voltage-gated channel Shaker-related subfamily A member 5 (KCNA5, KV1.5) |
| CAS | 748810-28-8 |
| MW: | 385.93 D |
ab 65,00 €
Moricizine
Artikelnummer: TGM-T16127-100mg
Description: Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances. Target: Others. Smiles: CCOC(=O)NC1=CC2=C(SC3=C(C=CC=C3)N2C(=O)CCN2CCOCC2)C=C1. References: Ahmmed, G.U., et al., Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes....
| Schlagworte: | Moracizine |
| Anwendung: | Targets voltage-gated sodium channel type V alpha (SCN5A, NAV1.5) |
| CAS | 31883-05-3 |
| MW: | 427.52 D |
ab 1.440,00 €
Moricizine Hydrochloride
Artikelnummer: TGM-T62942-100mg
Description: Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent that reduces the maximum rate of phase 0 depolarization, increases the repolarization rate of phases 2 and 3, decreases the duration of action potentials, and shortens the effective refractory period. Target: Others....
| Anwendung: | Targets voltage-gated sodium channel type V alpha (SCN5A, NAV1.5) |
| CAS | 29560-58-5 |
| MW: | 463.98 D |
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Lamotrigine-d3
Artikelnummer: Cay37196-5
Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Cay-15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM,...
| Schlagworte: | LTG-d3, 6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, oltage-gated sodium channel inhibitor |
| CAS | 1132746-94-1 |
| MW: | 259.1 D |
ab 250,00 €