Zu "K04836" wurden 37 Artikel gefunden!
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Phenytoin
Artikelnummer: Cay24037-50
Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin (Cay-23889). Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of...
| Schlagworte: | 5,5-Diphenylhydantoin, NSC 8722, 5,5-diphenyl-2,4-imidazolidinedione |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 57-41-0 |
| MW: | 252.3 D |
ab 44,00 €
Propafenone (hydrochloride)
Artikelnummer: Cay21871-5
Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium...
| Schlagworte: | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride |
| Anwendung: | Sodium channel blocker |
| CAS | 34183-22-7 |
| MW: | 377.9 D |
ab 49,00 €
Oxcarbazepine
Artikelnummer: Cay17340-250
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...
| Schlagworte: | GP47680, 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | 10-hydroxycarbazepine prodrug, voltage-gated sodium channel blocker |
| CAS | 28721-07-5 |
| MW: | 252.3 D |
ab 49,00 €
10,11-dihydro-10-hydroxy Carbamazepine
Artikelnummer: Cay18467-5
10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...
| Schlagworte: | 10,11-hydroxy-10,11 Dihydrocarbamezer, BIA 2-005, GP 47779, Licarbazepine,... |
| Anwendung: | Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker |
| CAS | 29331-92-8 |
| MW: | 254.3 D |
ab 75,00 €
Rufinamide
Artikelnummer: Cay18870-25
Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...
| Schlagworte: | CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
| Anwendung: | Antiepileptic |
| CAS | 106308-44-5 |
| MW: | 238.2 D |
ab 49,00 €
Disopyramide
Artikelnummer: Cay23227-5
Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. It is a class Ia antiarrhythmic agent that delays conduction through the AV node and ventricles of the dog heart both in vivo (3 and 5 mg/kg) and in vitro...
| Schlagworte: | (±)-Disopyramide, Ritmilen, SC-7031, alpha-[2-[bis(1-methylethyl)amino]ethyl]-alpha-phenyl-2-pyridineacetamide |
| Anwendung: | Sodium channel blocker |
| CAS | 3737-09-5 |
| MW: | 339.5 D |
ab 60,00 €
Eslicarbazepine Acetate
Artikelnummer: Cay23656-50
Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay). It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 µM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against...
| Schlagworte: | BIA 2-093, (10S)-10-(acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | Sodium channel blocker |
| CAS | 236395-14-5 |
| MW: | 296.3 D |
ab 139,00 €
ICA 121431
Artikelnummer: Cay24669-1
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 µM but...
| Schlagworte: | alpha-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide |
| Anwendung: | Voltage-gated sodium channel (Nav) blocker |
| CAS | 313254-51-2 |
| MW: | 449.5 D |
ab 49,00 €
Flecainide (acetate)
Artikelnummer: Cay20388-50
Flecainide is an inhibitor of cardiac late sodium current (INa, IC50 = 3.4 µM) and delayed-rectifier potassium current (IKr, IC50 = 1.5 µM). Formulations containing flecainide have been used in the treatment of arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart...
| Schlagworte: | N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamide, monoacetate |
| Anwendung: | Antiarrhythmic, sodium channel blocker |
| CAS | 54143-56-5 |
| MW: | 474.4 D |
ab 49,00 €
(-)-Ropivacaine (hydrochloride hydrate)
Artikelnummer: Cay21422-50
(-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 µL of an 8 mM solution is injected percutaneously into the sciatic nerve. (-)-Ropivacaine...
| Schlagworte: | (S)-Ropivacaine, LEA 103, (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide, monohydrochloride, monohydrate |
| Anwendung: | Potent, reversible sodium channel blocker |
| CAS | 132112-35-7 |
| MW: | 328.9 D |
ab 95,00 €
Fosphenytoin (sodium salt)
Artikelnummer: Cay23889-500
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo. It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration. Fosphenytoin has anticonvulsant activity in a mouse...
| Schlagworte: | ACC-9653, Cl-982, 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt |
| Anwendung: | Voltage-gated sodium channel blocker prodrug |
| CAS | 92134-98-0 |
| MW: | 406.2 D |
ab 67,00 €
Zonisamide
Artikelnummer: Cay24183-250
Zonisamide is a broad-spectrum sulfonamide antiepileptic agent. It selectively blocks the repeated firing of sodium channels (IC50 = 2 µg/ml) at low concentrations in mouse embryo spinal cord neurons, and it blocks spontaneous channel firing at concentrations above 10 µg/ml. In rat cerebral cortex neurons,...
| Schlagworte: | CI-912, PD 110843, 1,2-benzisoxazole-3-methanesulfonamide |
| Anwendung: | Antiepileptic |
| CAS | 68291-97-4 |
| MW: | 212.2 D |
ab 85,00 €