Zu "K04813" wurden 41 Artikel gefunden!
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5-iodo A-85380 (hydrochloride)
Artikelnummer: Cay43194-10
An agonist of alpha4beta2 and alpha6beta2 subunit-containing nAChRs, activates alpha-conotoxin MII-sensitive and -insensitive dopamine release in rat striatal synaptosomes, markers of alpha4beta2 and alpha6beta2 subunit-containing nAChR activation, respectively (EC50s = 12.7 and ~35 nM, respectively), decreases the...
| Schlagworte: | 3-[(2S)-2-azetidinylmethoxy]-5-iodo-pyridine, dihydrochloride |
| Anwendung: | alpha4beta2 / alpha6beta2 subunit-containing nAChR agonist |
| CAS | 1217837-17-6 |
| MW: | 363 D |
ab 112,00 €
Varenicline (tartrate)
Artikelnummer: Cay15030-5
Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs (EC50 = 2.3 µM). Formulations containing varenicline have been used as aids in smoking cessation.Formal Name:...
| Schlagworte: | CP 526,555-18, 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine-(2R,3R)-dihydroxybutanedioate |
| Anwendung: | alpha4beta2 neuronal nicotinic acetylcholine receptor agonist |
| CAS | 375815-87-5 |
| MW: | 361.4 D |
ab 158,00 €
TMB 8 (hydrochloride)
Artikelnummer: Cay23928-10
TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and alpha3beta4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain...
| Schlagworte: | 3,4,5-trimethoxy-benzoic acid, 8-(diethylamino)octyl ester, monohydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor non-competitive antagonist |
| CAS | 53464-72-5 |
| MW: | 432 D |
ab 42,00 €
Varenicline-d4
Artikelnummer: Cay26102-500
Varenicline-d4 is intended for use as an internal standard for the quantification of varenicline (Cay-15030) by GC- or LC-MS. Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs...
| Schlagworte: | 7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline-7,7,9,9-d4 |
| Anwendung: | GC-MS, LC-MS, internal standard, alpha4beta2 neuronal nicotinic acetylcholine receptor agonist |
| CAS | 2183239-01-0 |
| MW: | 215.3 D |
ab 139,00 €
Anti-CHRNB2, Internal
Artikelnummer: ARG64701.100
Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. [The UniProt Consortium]
| Schlagworte: | Anti-CHRNB2, Anti-Neuronal acetylcholine receptor subunit beta-2 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Anti-CHRNB2
Artikelnummer: NSJ-R35399-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cholinergic receptor nicotinic beta 2 Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an...
| Schlagworte: | Anti-CHRNB2, Anti-Neuronal acetylcholine receptor subunit beta-2, CHRNB2 Antibody |
| Anwendung: | WB, IHC (paraffin), ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Varenicline Tartrate
Artikelnummer: LKT-V0369.10
alpha7 and beta4 nAChR agonist, alpha4beta2 and alpha6beta2 nAChR partial agonist.
| Anwendung: | alpha-4 beta-2 nicotinic receptor partial agonist |
| CAS | 375815-87-5 |
| MW: | 361.35 D |
ab 116,00 €
Morantel (tartrate)
Artikelnummer: Cay22902-250
Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs). It enhances channel gating of the alpha3beta2 nAChR subtype by binding to non-canonical sites. Formulations containing morantel are used to treat nematode infections in livestock.Formal Name:...
| Schlagworte: | CP 12,009-18, UK 2964-18, 1,4,5,6-tetrahydro-1-methyl-2-[(2E)-2-(3-methyl-2-thienyl)ethenyl]-pyrimidine,... |
| Anwendung: | Anthelmintic, nicotinic cholinergic receptor alpha3beta2 enhancer |
| CAS | 26155-31-7 |
| MW: | 370.4 D |
ab 56,00 €
MG624
Artikelnummer: Cay24298-1
MG624 is an antagonist of neuronal nicotinic acetylcholine receptors (nAChRs, Ki = 0.055 µM in neuronal chick optic lobe membranes). It is selective for neuronal nAChRs over muscle-type AChRs (Ki = 70 µM in TE671 cells that express muscle-type AChRs). MG624 inhibits currents evoked by acetylcholine in Xenopus...
| Schlagworte: | N,N,N-triethyl-2-[4-[(1E)-2-phenylethenyl]phenoxy]-ethanaminium, monoiodide |
| Anwendung: | nAChR antagonist |
| CAS | 77257-42-2 |
| MW: | 451.4 D |
ab 49,00 €
(±)-Anabasine (hydrochloride)
Artikelnummer: Cay18206-50
(±)-Anabasine is an alkaloid that has been found as a minor component in tobacco (Nicotiana). It is a full agonist of nicotinic acetylcholine receptors (nAChRs) that induces depolarization of TE 671 cells endogenously expressing human fetal muscle-type nAChRs (EC50 = 10.1 µM) but not SH-SY5Y cells that primarily...
| Schlagworte: | 3-(piperidin-2-yl)pyridine, hydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor alpha4beta2 subtype ligand |
| MW: | 162.2 D |
ab 49,00 €
Hydroxy Varenicline
Artikelnummer: Cay22388-1
Hydroxy varenicline is a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline (Cay-15030).Formal Name: 1,6,7,8,9,10-hexahydro-6,10-methano-2H-pyrazino[2,3-h][3]benzazepin-2-one. CAS Number: 357424-21-6. Synonyms: 2-Hydroxyvarenicline. Molecular Formula: C13H13N3O. Formula Weight: 227.3....
| Schlagworte: | 2-Hydroxyvarenicline, 1,6,7,8,9,10-hexahydro-6,10-methano-2H-pyrazino[2,3-h][3]benzazepin-2-one |
| Anwendung: | Varenicline metabolite |
| CAS | 357424-21-6 |
| MW: | 227.3 D |
ab 108,00 €
ABT-594 (hydrochloride)
Artikelnummer: Cay22822-5
ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C-...
| Schlagworte: | Ebanicline, Tebanicline, 5-[(2R)-2-azetidinylmethoxy]-2-chloro-pyridine, monohydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor partial agonist |
| CAS | 203564-54-9 |
| MW: | 235.1 D |
ab 56,00 €