Zu "K04805" wurden 30 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
NS 3861
Artikelnummer: Cay37406-10
NS 3861 is a neuronal nicotinic acetylcholine receptor (nAChR) agonist. It induces inward currents in patch-clamp assays using X. laevis oocytes expressing recombinant human alpha3beta2- or alpha3beta4 subunit-containing nAChR receptors (EC50s = 1.6 and 1 µM, respectively). In vivo, NS 3861 (0.1 mg/kg) increases the...
| Schlagworte: | 3-(3-bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene |
| Anwendung: | Neuronal nAChR agonist |
| CAS | 216853-59-7 |
| MW: | 284.2 D |
ab 133,00 €
Human CHRNa3 (Cholinergic Receptor, Nicotinic, Alpha 3)...
Artikelnummer: ELK-ELK4288.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CHRNa3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CHRNa3....
| Schlagworte: | CHRNA3, NACHRA3, Neuronal acetylcholine receptor subunit alpha-3 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
(±)-Nicotine
Artikelnummer: Cay16535-100
(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for alpha3beta4 and alpha4beta2 subtypes, respectively) and possesses addictive and teratogenic properties. (-)-(S)-Nicotine is...
| Schlagworte: | DL-Nicotine, 3-(1-methyl-2-pyrrolidinyl)-pyridine |
| Anwendung: | nAChR agonist |
| CAS | 22083-74-5 |
| MW: | 162.2 D |
ab 135,00 €
Mecamylamine (hydrochloride)
Artikelnummer: Cay14602-10
Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the alpha3beta4 subtype (IC50 = 90-640 nM) compared to alpha4beta2, alpha3beta2, and alpha7 subtypes (IC50 range from 1-7 µM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic...
| Schlagworte: | Inversine, N,2,3,3-tetramethyl-bicyclo[2.2.1]heptan-2-amine, monohydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor antagonist |
| CAS | 826-39-1 |
| MW: | 203.8 D |
ab 60,00 €
Morantel (tartrate)
Artikelnummer: Cay22902-100
Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs). It enhances channel gating of the alpha3beta2 nAChR subtype by binding to non-canonical sites. Formulations containing morantel are used to treat nematode infections in livestock.Formal Name:...
| Schlagworte: | CP 12,009-18, UK 2964-18, 1,4,5,6-tetrahydro-1-methyl-2-[(2E)-2-(3-methyl-2-thienyl)ethenyl]-pyrimidine,... |
| Anwendung: | Anthelmintic, nicotinic cholinergic receptor alpha3beta2 enhancer |
| CAS | 26155-31-7 |
| MW: | 370.4 D |
ab 50,00 €
Chlorisondamine (iodide)
Artikelnummer: Cay20119-25
Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs, IC50 = 1.8 µM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Cay-16535, Cay-20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 µM....
| Schlagworte: | 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-1H-isoindolium, diiodide |
| Anwendung: | Nicotinic acetylcholine receptor antagonist |
| CAS | 96750-66-2 |
| MW: | 611.9 D |
ab 50,00 €
Anti-CHRNA3
Artikelnummer: E-AB-15792.120
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a...
| Schlagworte: | Anti-CHRNA3, Anti-NACHRA3, Anti-Neuronal acetylcholine receptor subunit alpha-3, CHRNA3 Polyclonal Antibody |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €
Cisatracurium (besylate)
Artikelnummer: Cay22959-250
Cisatracurium is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs) and non-depolarizing muscle relaxant. It inhibits stimulation of human adult muscle nAChRs by acetylcholine (Cay-23829) with an IC50 value of 10 nM. It also inhibits mouse nAChRs with IC50 values of 54 and 115 nM for adult and...
| Schlagworte: | (1R,1'R,2R,2'R)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydr... |
| Anwendung: | nAChR competitive antagonist |
| CAS | 96946-42-8 |
| MW: | 1243.5 D |
ab 125,00 €
(±)-Nicotine-d3
Artikelnummer: Cay18256-5
(±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Cay-16535) by GC- or LC-MS. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for...
| Schlagworte: | (±)-Nicotine-methyl-d3, DL-Nicotine-d3, 3-[1-(methyl-d3)-2-pyrrolidinyl]-pyridine |
| Anwendung: | nAChR agonist, internal control |
| CAS | 69980-24-1 |
| MW: | 165.3 D |
ab 50,00 €
(-)-Cytisine
Artikelnummer: CDX-C0228-G005
Light yellow powder/crystals. Soluble in toluene. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking...
| Schlagworte: | NSC 407282, BRN 0083882, Baptitoxine, Sophorine,... |
| Anwendung: | Nicotine agonist, Iron chelator, Hydroxyl radical scavanger |
| CAS | 485-35-8 |
| MW: | 190,2 D |
ab 168,00 €
ABT-594 (hydrochloride)
Artikelnummer: Cay22822-10
ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C-...
| Schlagworte: | Ebanicline, Tebanicline, 5-[(2R)-2-azetidinylmethoxy]-2-chloro-pyridine, monohydrochloride |
| Anwendung: | Nicotinic acetylcholine receptor partial agonist |
| CAS | 203564-54-9 |
| MW: | 235.1 D |
ab 50,00 €
Hexamethonium (bromide)
Artikelnummer: Cay25505-10
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs). It decreases acetylcholine release induced by carbamoylcholine (Cay-14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and...
| Schlagworte: | N1,N1,N1,N6,N6,N6-hexamethyl-1,6-hexanediaminium, dibromide |
| Anwendung: | Peripherally-acting muscle relaxant, Nicotinic acetylcholine receptor antagonist |
| CAS | 55-97-0 |
| MW: | 362.2 D |
ab 34,00 €