Zu "K04725" wurden 108 Artikel gefunden!
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Anti-XIAP
Artikelnummer: ATA-HPA060093.100
Rabbit Polyclonal XIAP Antibody against Human X-linked inhibitor of apoptosis. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000025860: 86%,...
| Schlagworte: | Anti-ILP, Anti-hILP, Anti-XIAP, Anti-API3, Anti-hIAP3, Anti-IAP-3, Anti-hIAP-3, EC=2.3.2.27, Anti-X-linked IAP,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 264,00 €
XIAP, active human recombinant protein
Artikelnummer: BPS-80401
Human XIAP (GenBank Accession No. NM_001167), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW= 57 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
| Schlagworte: | ILP, API3, hILP, IAP-3, hIAP3, hIAP-3, X-linked IAP, IAP-like protein, E3 ubiquitin-protein ligase XIAP, Inhibitor of... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 57 kD |
625,00 €
Birinapant
Artikelnummer: Cay19699-25
Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation,...
| Schlagworte: | TL-32711,... |
| Anwendung: | Antineoplastic, XIAP / cIAP1 inhibitor |
| CAS | 1260251-31-7 |
| MW: | 806.9 D |
ab 85,00 €
SM-164
Artikelnummer: Cay28632-1
SM-164 is a cell-permeable bivalent mimetic of Smac and an inhibitor of X-linked inhibitor of apoptosis (XIAP). It binds to BIR2 and BIR3 domain-containing XIAP with an IC50 value of 1.39 nM and interacts with both domains. SM-164 inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and...
| Schlagworte: | (3S,3'S,6S,6'S,10aS,10'aS)-N,N'-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[deca... |
| Anwendung: | Cell-permeable bivalent Smac mimetic, XIAP inhibitor |
| CAS | 957135-43-2 |
| MW: | 1121.4 D |
ab 147,00 €
Embelin
Artikelnummer: Cay11838-10
Embelin is a benzoquinone that has been found in E. ribes and has diverse biological activities. It inhibits viral replication of the influenza A subtype H1N1 and the influenza B subtype Victoria-like in MDCK cells (IC50s = 0.3 and 0.2 µM, respectively). It is also an inhibitor of X-linked inhibitor of apoptosis...
| Schlagworte: | NSC 91874, 2,5-dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
| Anwendung: | Apoptosis inducer, XIAP inhibitor |
| CAS | 550-24-3 |
| MW: | 294.4 D |
ab 102,00 €
XIAP, Bir2-Bir3 Domains, His-Tag Recombinant
Artikelnummer: BPS-75002
Human x-linked inhibitor of apoptosis (XIAP), also known as IAP-like protein, API3, X-linked IAP, and BIRC4, amino-acids 120 ? 356 containing Bir2 and Bir3 domains (GenBank Accession No. NM_001167) with N-terminal His-tag, MW = 28.3 kDa, expressed in an E. coli expression system.
| Schlagworte: | ILP, API3, hILP, IAP-3, hIAP3, hIAP-3, X-linked IAP, IAP-like protein, E3 ubiquitin-protein ligase XIAP, Inhibitor of... |
| Anwendung: | Binding and inhibition studies, screening inhibitors, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 28.3 kD |
528,00 €
GDC-0152
Artikelnummer: Cay17810-5
Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells. GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2...
| Schlagworte: | N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-L-prolinamide |
| Anwendung: | Caspase activator |
| CAS | 873652-48-3 |
| MW: | 498.6 D |
ab 67,00 €
MX69
Artikelnummer: Cay27224-5
MX69 is an inhibitor of the interaction between the ubiquitin ligase MDM2 protein and XIAP mRNA. It binds to the RING domain of MDM2 (Kd = 2.34 µM) and decreases the levels of MDM2 and XIAP in a concentration-dependent manner without affecting the levels of Bcl-2, cIAP-1, and cIAP-2. It induces autoubiquitination...
| Schlagworte: | 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-benzoic acid |
| Anwendung: | MDM2 protein - XIAP mRNA interaction inhibitor |
| CAS | 1005264-47-0 |
| MW: | 474.6 D |
ab 73,00 €
Anti-XIAP, clone 1020CT7.2.2
Artikelnummer: ARG56215.100
Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the...
| Schlagworte: | Anti-ILP, Anti-XIAP, Anti-API3, Anti-hILP, Anti-hIAP3, Anti-IAP-3, Anti-hIAP-3, EC=2.3.2.27, Anti-X-linked IAP,... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
616,00 €
Anti-XIAP
Artikelnummer: ARG56556.50
Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the...
| Schlagworte: | Anti-ILP, Anti-XIAP, Anti-API3, Anti-hILP, Anti-hIAP3, Anti-IAP-3, Anti-hIAP-3, EC=2.3.2.27, Anti-X-linked IAP,... |
| Anwendung: | IHC (paraffin), WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
625,00 €
Cisplatin
Artikelnummer: BPS-27744
Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-alpha-induced apoptosis.
| Schlagworte: | CDDP, azane, dichloroplatinum(2+), |
| Anwendung: | Apoptosis inhibitor, anticancer agent, DNA synthesis blocker |
| MW: | 300.1 D |
357,00 €
XIAP (Bir3), human recombinant protein, His-tag
Artikelnummer: BPS-75001
Human x-linked inhibitor of apoptosis (XIAP) Bir3 domain, also known as IAP-like protein, API3, X-linked IAP, and BIRC4, amino-acids 241 ? 356 (GenBank Accession No. NM_001167) with N-terminal His-tag, MW = 14.2 kDa, expressed in an E. coli expression system.
| Schlagworte: | ILP, API3, hILP, IAP-3, hIAP3, hIAP-3, X-linked IAP, IAP-like protein, E3 ubiquitin-protein ligase XIAP, Inhibitor of... |
| Anwendung: | Binding and inhibition studies, screening inhibitors, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 14.2 kD |
528,00 €